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    Natural Products
    Kaempferol tetraacetate
    Information
    CAS No. 16274-11-6 Price
    Catalog No.CFN99686Purity>=98%
    Molecular Weight454.4 Type of CompoundFlavonoids
    FormulaC23H18O10Physical DescriptionPowder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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    Kaempferol tetraacetate

    Kaempferol tetraacetate
    Product Name Kaempferol tetraacetate
    CAS No.: 16274-11-6
    Catalog No.: CFN99686
    Molecular Formula: C23H18O10
    Molecular Weight: 454.4 g/mol
    Purity: >=98%
    Type of Compound: Flavonoids
    Physical Desc.: Powder
    Targets: Antifection
    Source: The herbs of Cudrania tricuspidata
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price:
    Inquire / Order: manager@chemfaces.com
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  • Pak J Pharm Sci.2018, 31:311-315
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  • Eur Rev Med Pharmacol Sci.2020, 24(9):5127-5139.
  • Nutrients.2017, 10(1)
  • Sci Rep.2017, 7(1):3249
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  • J Ethnopharmacol.2017, 206:327-336
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Cytotoxic Compound Library
  • Anti-platelet aggregation Compound Library
  • Flavonoids Compound Library
  • Antifection Inhibitor Library
  • Biological Activity
    Description: Kaempferol tetraacetate is a potent antiplatelet agent. It exhibits significant cytotoxicity in vitro against three human cell lines HL-60, U937 and SK-MEL-1.
    Targets: Antifection
    In vitro:
    J Nat Prod. 1993 Jun;56(6):929-34.
    Antiplatelet effects and vasorelaxing action of some constituents of Formosan plants.[Pubmed: 8350094]

    METHODS AND RESULTS:
    Various xanthones as well as quercetin have been shown to exhibit antiplatelet activity. A series of anthraquinones analogues structurally related to xanthones and a series of quercetin-related compounds were tested for their antiplatelet effects.
    CONCLUSIONS:
    Emodin, frangulin B, Kaempferol tetraacetate, quercetin-3-O-galactoside octaacetate, rhamnazin triacetate, and rhamnetin tetraacetate were found to be potent antiplatelet agents, and 1,8-dihydroxy-6-methoxy-3-methylanthraquinone 8-O-rhamnosyl-(1-->2)-glucoside, rhamnustrioside undecaacetate, rutin decaacetate, and quercetin-3-O-(6-O-alpha-L-arabinopyranosyl)-beta-D-galactopyranos ide decaacetate showed significant antiplatelet effects. Quercetin showed vasorelaxing action in rat thoracic aorta.
    Planta Med. 2008 Feb;74(2):171-4.
    Cytotoxic activities of flavonoid glycoside acetates from Consolida oliveriana.[Pubmed: 18214815]

    METHODS AND RESULTS:
    The flavonoids kaempferol, quercetin, trifolin, hyperoside 2''- and 6''- acetates, 7-glucotrifolin, biorobin and robinin were isolated from the aerial parts of Consolida oliveriana.
    CONCLUSIONS:
    Their derivatives Kaempferol tetraacetate, quercetin pentaacetate, trifolin heptaacetate and hyperoside octaacetate exhibited significant cytotoxicity IN VITRO against three human cell lines HL-60, U937 and SK-MEL-1 while hyperoside 2''-acetate, hyperoside-6''-acetate, glucotrifolin decaacetate and heptamethyltrifolin were inactive.
    Kaempferol tetraacetate Description
    Source: The herbs of Cudrania tricuspidata
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.2007 mL 11.0035 mL 22.007 mL 44.0141 mL 55.0176 mL
    5 mM 0.4401 mL 2.2007 mL 4.4014 mL 8.8028 mL 11.0035 mL
    10 mM 0.2201 mL 1.1004 mL 2.2007 mL 4.4014 mL 5.5018 mL
    50 mM 0.044 mL 0.2201 mL 0.4401 mL 0.8803 mL 1.1004 mL
    100 mM 0.022 mL 0.11 mL 0.2201 mL 0.4401 mL 0.5502 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Beilstein J Org Chem. 2015 Feb 25;11:288-93.
    Selective methylation of kaempferol via benzylation and deacetylation of kaempferol acetates.[Pubmed: 25815082]
    A strategy for selective mono-, di- and tri-O-methylation of kaempferol, predominantly on the basis of selective benzylation and controllable deacetylation of kaempferol acetates, was developed.
    METHODS AND RESULTS:
    From the selective deacetylation and benzylation of Kaempferol tetraacetate (1), 3,4',5,-tri-O-acetylkaempferol (2) and 7-O-benzyl-3,4'5,-tri-O-acetylkaempferol (8) were obtained, respectively. By controllable deacetylation and followed selective or direct methylation of these two intermediates, eight O-methylated kaempferols were prepared with 51-77% total yields from kaempferol.
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