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    Natural Products
    Kuwanon H
    Information
    CAS No. 76472-87-2 Price $288 / 10mg
    Catalog No.CFN90835Purity>=98%
    Molecular Weight760.8Type of CompoundFlavonoids
    FormulaC45H44O11Physical DescriptionYellow powder
    Download     COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
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    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $247.7 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
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    Kuwanon H

    Kuwanon H
    Product Name Kuwanon H
    CAS No.: 76472-87-2
    Catalog No.: CFN90835
    Molecular Formula: C45H44O11
    Molecular Weight: 760.8 g/mol
    Purity: >=98%
    Type of Compound: Flavonoids
    Physical Desc.: Yellow powder
    Targets: GRP
    Source: The root barks of Morus alba L.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $288 / 10mg
    Inquire / Order: manager@chemfaces.com
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  • J Biomed Sci.2020, 27(1):60.
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
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  • Antagonists Compound Library
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  • Biological Activity
    Description: Kuwanon H, and possibly kuwanon G also, are specific antagonists for the gastrin-releasing peptide (GRP) -preferring receptor and can be useful for studying the physiological and pathological role of GRP.
    Targets: GRP
    In vitro:
    Biochem Biophys Res Commun. 1995 Aug 15;213(2):594-9.
    Non-peptide bombesin receptor antagonists, kuwanon G and H, isolated from mulberry.[Pubmed: 7646517 ]

    METHODS AND RESULTS:
    Kuwanon G and H, isolated from the methanol extract of Morus bombycis, inhibited specific binding of [125I]gastrin-releasing peptide (GRP) to GRP-preferring receptors in murine Swiss 3T3 fibroblasts with Ki values of 470 and 290 nM, respectively. Kuwanon H was one order of magnitude less potent for inhibiting [125I]bombesin binding to neuromedin B (NMB)-preferring receptors in rat esophagus membranes. This compound antagonized bombesin-induced increases in the cytosolic free calcium concentration and GRP-induced DNA synthesis in Swiss 3T3 cells.
    CONCLUSIONS:
    Thus, Kuwanon H, and possibly kuwanon G also, are specific antagonists for the GRP-preferring receptor and can be useful for studying the physiological and pathological role of GRP.
    Kuwanon H Description
    Source: The root barks of Morus alba L.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.3144 mL 6.572 mL 13.1441 mL 26.2881 mL 32.8601 mL
    5 mM 0.2629 mL 1.3144 mL 2.6288 mL 5.2576 mL 6.572 mL
    10 mM 0.1314 mL 0.6572 mL 1.3144 mL 2.6288 mL 3.286 mL
    50 mM 0.0263 mL 0.1314 mL 0.2629 mL 0.5258 mL 0.6572 mL
    100 mM 0.0131 mL 0.0657 mL 0.1314 mL 0.2629 mL 0.3286 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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