ChemFaces is a professional high-purity natural products manufacturer.
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Citing Use of our Products
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $227.8 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Tumour Biol.2015, 36(12):9385-93Evid Based Complement Alternat Me...2016...Research on Crops.2017, 18(2)Int J Anal Chem.2017, 2017:1254721Evid Based Complement Alternat Me...2017...Invest New Drugs.2017, 35(2):166-179Chem Pharm Bull (Tokyo)....2017...Front Pharmacol.2017, 8:673
Microchemical Journal2018, 137:168-173Int J Mol Sci.2018, 19(9):E2681International Food Research Journ...2018...Biosci Rep.2018, 38(4)Korean J. Crop Sci.2018, 63(2):131-139Journal of Ginseng Research...2019...Drug Invention Today...2019...Chem Biol Interact.2019, 315:108910
J Food Sci Technol....2019...Oxid Med Cell Longev2019, 9056845:13Food Res Int.2020, 128:108778Nutrients.2020, 12(12):3607. Curr Top Med Chem....2020...Int J Mol Sci.2020, 21(24):9369.Horticulturae2021, 7(1),5.
Our products had been exported to the following research institutions and universities, And still growing.
Lund University (Sweden)Northeast Normal University Cha... (China)Monash University Malaysia (Malaysia)University of British Columbia (Canada)
Centrum Menselijke Erfelijkheid (Belgium)Periyar University (India)National Cancer Institute (USA)Martin Luther University of Hal... (Germany)
Institute of Chinese Materia Me... (China)Molecular Biology Institute of ... (Spain)Lodz University of Technology (Poland)
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Front Pharmacol.2017, 8:673J Biomed Sci.2020, 27(1):60.Comput Biol Chem.2019, 83:107096Biomed Pharmacother.2019, 116:108987Biomolecules.2020, 10(6):925.J Mol Recognit.2020, 33(2):e2819Sci Rep.2019, 9(1):6429J of the Korean Society of Cosmetics and Cosmetology2019, 225-231Front Endocrinol (Lausanne).2020, 11:568436.Naunyn Schmiedebergs Arch Pharmacol.2017, 390(10):1073-1083
Related Screening Libraries
||Licoisoflavone A is a potential MRP inhibitor, it shows inhibitory effects on copper-induced protein oxidative modification of mice brain homogenate in vitro. |
|Biol Trace Elem Res. 2001 Aug;81(2):169-75. |
|Inhibitory effects of licoisoflavones A and B and sophoraisoflavone A of Sophra mooracroftiana Beth ex Baker on copper-ion-induced protein oxidative modification of mice brain homogenate, in vitro.[Pubmed: 11554397]|
METHODS AND RESULTS:
We present the results of an in vitro investigation of the inhibitory effects of licoisoflavones A and B and sophoraisoflavone A isolated from Sophra mooracroftiana BETH ex BAKER on copper-induced protein oxidative modification of mice brain homogenate in vitro. Although inhibitory effect of sophoraisoflavone A was stronger than those of licoisoflavones A and B, genistein as a related isoflavone, and mannitol as a hydroxy radical scavenger, inhibitory effects of licoisoflavones A and B were weaker than those of genistein and mannitol.
These results demonstrated that the difference of inhibitory effects are dependent on the relation between chemical structures of these isoflavones, such as hydroxy group or benzopyran, and oxidative stress.
Licoisoflavone A Description
||The roots of Glycyrrhiza uralensis Fisch
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Blood Cells Mol Dis. 2001 Sep-Oct;27(5):894-900. |
|Monitoring of MRP-like activity in human erythrocytes: inhibitory effect of isoflavones.[Pubmed: 11783953]|
|A method to fluorometrically monitor efflux of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein (BCPCF) from human erythrocytes was developed.
Genistein, daidzein, sophoraisoflavone A, and Licoisoflavone A induced 50% inhibition (IC(50)) of BCPCF efflux at 15-70 microM. The IC(50) value of the most efficient isoflavone, Licoisoflavone A (15-25 microM), was comparable to that of indomethacin (approximately 10 microM) and markedly lower than for probenecid (100-200 microM), both known MRP1 inhibitors.
Our results indicate that the human erythrocyte is a useful cell model in screening potential MRP inhibitors, that BCPCF is a good substrate for MRP, and that some isoflavones at low concentrations inhibit MRP-mediated efflux.