ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
Citing Use of our Products
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Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Food Chem.2019, 276:768-775J Phys Chem Lett.2021, 12(7):1793-1802.Appl. Sci.2020, 10(5),1713.Food Research2021, 5(1):65-71Sci Rep.2018, 8:9267Evid Based Complement Alternat Me...2021...Elife.2021, 10:e68058. Phytomedicine.2019, 55:229-237
Antioxidants (Basel).2021, 10(10):1638.Molecules 2022, 27(3),960.Evid Based Complement Alternat Me...2015...J Microbiol Biotechnol....2022...Trop J Nat Prod Res.2019, 3(1):6-9Int J Oncol.2019, 55(1):320-330J AOAC Int.2023, 106(1):56-64.Molecules.2021, 26(4):816.
Food Chem.2021, 377:131976. Analytical sci. & Tech2016, 186-193Molecules.2019, 25(1):E103Journal of Ginseng Research...2021...Pharmaceuticals (Basel)....2022...US20170000760 A12016, 42740Korean J. Medicinal Crop Sci...2021...
Our products had been exported to the following research institutions and universities, And still growing.
Instituto de Investigaciones Ag... (Chile)Kyushu University (Japan)Florida International University (USA)Rio de Janeiro State University (Brazil)
Universidad Industrial de Santa... (Colombia)Institute of Tropical Disease U... (Indonesia)University of Lodz (Poland)University of Hertfordshire (United Kingdom)
The Institute of Cancer Research (United Kingdom)Uniwersytet Jagielloński w Kra... (Poland)University of East Anglia (United Kingdom)
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Foods.2022, 12(1):136. J Mass Spectrom.2022, 57(2):e4810.New Zealand J. Forestry Sci.2014, 44:17Asian J Beauty Cosmetol2021, 19(1): 57-64.J Hematol Oncol.2018, 11(1):112Journal of Food Composition and Analysis2021, 100:103905.Food Chem.2023, 404(Pt A):134517.Antioxidants (Basel).2021, 10(9):1435.Institute of Food Science & Technology2021, 45(9).Kasetsart University2022, ethesis.1144.
Related Screening Libraries
||Linderone A shows anticancer activity against A549 non-small cell lung cancer cells and PC-3 prostate adenocarcinoma cell line. |
|Comb Chem High Throughput Screen. 2013 Feb;16(2):160-6. |
|Flavonoids and linderone from Lindera oxyphylla and their bioactivities.[Pubmed: 23173924]|
A new Linderone A, namely 2-cinnamoyl-3-hydroxy-4, 5-dimethoxycyclopenta-2, 4-dienone (5), together with three known flavonoids (1-3) and one Linderone (4), were isolated from the bark of Lindera oxyphylla.
METHODS AND RESULTS:
Extensive spectroscopic analysis including 1D and 2D-NMR spectra determined their sturctures. In addition, the antioxidant activity of all the compounds has been determined using 2, 2-diphenyl-1-picrylhydrazyl radical scavenging (DPPH), ferric reducing antioxidant power (FRAP) and ferrous ion chelating (FIC) methods. Compound 3 showed excellent DPPH scavenging activity with IC50% value of 8.5 ± 0.004% (μg/mL) which is comparable with vitamin C. This compound, also showed an absorbance value of 1.00 ± 0.06% through FRAP test when compared with Butyl Hydroxy Aniline (BHA). However, FIC showed low activity for all the isolated compounds (chelating activity less than 50%) in comparison with ethylene diamine tetra acetic acid (EDTA). Anticancer activity for all compounds has also been measured on A375 human melanoma, HT-29 colon adenocarcinoma, MCF-7 human breast adenocarcinoma cells, WRL-68 normal hepatic cells, A549 non-small cell lung cancer cells and PC-3 prostate adenocarcinoma cell line.
Compound 1 showed A549=65.03%, PC-3=30.12%, MCF-7=47.67, compound 2 showed PC-3=90.13%, compound 3 showed MCF-7=79.57 and for compound 5 MCF-7 is 96.33.
|Org Lett. 2010 May 21;12(10):2354-7. |
|Bi-linderone, a highly modified methyl-linderone dimer from Lindera aggregata with activity toward improvement of insulin sensitivity in vitro.[Pubmed: 20420414]|
|Bi-Linderone (1) was isolated as racemate from the traditional Chinese medicinal plant Lindera aggregata.
METHODS AND RESULTS:
The structure elucidation of bi-Linderone was reported on the basis of extensive analysis of NMR spectra and crystal X-ray diffraction. Bi-Linderone has an unprecedented spirocyclopentenedione-containing carbon skeleton and showed significant activity against glucosamine-induced insulin resistance in HepG2 cells at a concentration of 1 microg/mL.
||The roots of Lindera aggregata (Sims) Kosterm
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Org Lett. 2011 May 6;13(9):2192-5. |
|Biomimetic total syntheses of linderaspirone A and bi-linderone and revisions of their biosynthetic pathways.[Pubmed: 21446662]|
METHODS AND RESULTS:
Simple exposure to sunlight is sufficient for triggering photochemical [2 + 2] cycloaddition-Cope or radical rearrangement cascades in the naturally occurring methyl Linderone, leading to efficient biomimetic total syntheses of linderaspirone A and bi-Linderone, two recently discovered bioactive spirocyclopentenedione natural products.
|Mini Rev Med Chem. 2014 Apr;14(4):322-31. |
|Chemical properties and biological activities of cyclopentenediones: a review.[Pubmed: 24605879]|
METHODS AND RESULTS:
Cyclopentenediones (CPDs) are secondary metabolites of higher plants, fungi, algae, cyanobacteria and bacteria. A common denominator of CPDs is the cyclopent-4-ene-1,3-dione skeleton (1), which is modified by several functional groups. The heterogeneity of these substitutions is reflected in around one hundred CPDs reported to date. Most of the derivatives were isolated primarily from plant sources.
Synthetic analogues were then prepared with new biological activities and more interesting pharmacological potential.
Antifungal substances called coruscanones (2, 3) are the most studied of the CPDs. Other intensely investigated CPDs include lucidone (4), Linderone (5), asterredione (6), involutone (7), nostotrebin 6 (8), TX-1123 (9), G2201-C (10), madindolines (11, 12) and many others.