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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $7.0 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Molecules.2015, 20(11):20014-30Phytomedicine.2015, 22(11):1027-36Acta Biochim Pol.2015, 62(2):253-8Int J Mol Sci.2017, 18(12)Sci Rep. 2018, 1-9Int J Mol Sci.2018, 19(9):E2825Evid Based Complement Alternat Me...2018...Chem Biol Interact.2018, 283:59-74
J Sep Sci.2018, 41(9):1938-1946J Pharm Biomed Anal.2019, 172:268-277Molecules.2019, 24(2):329Pak J Pharm Sci.2019, 32(6)TCI CO.2019, US20190151281A1Plant Foods Hum Nutr.2020, 10.1007Int J Pharmacol2020, 16:1-9Toxins (Basel).2020, 12(4):210.
Biomed Pharmacother.2020, 131:110673.South African J of Botany...2020...Int J Mol Sci.2020, 21(9):3392. Biochem Biophys Res Commun....2020...J Chromatogr Sci.2020, 58(6):485-493.Nature Ecology & Evolution...2020...Ulm University Medical Center...2020...
Our products had been exported to the following research institutions and universities, And still growing.
Aarhus University (Denmark)Universidad de Antioquia (Colombia)University of Hertfordshire (United Kingdom)University of Limpopo (South Africa)
Imperial College London (United Kingdom)Charles University in Prague (Czech Republic)University of Malaya (Malaysia)Chang Gung University (Taiwan)
University of British Columbia (Canada)Fraunhofer-Institut für Moleku... (Germany)Universidad de Buenos Aires (Argentina)
Related Screening Libraries
||Mannitol is a osmotic diuretic, it may play a role in reducing off-target 68Ga-PSMA renal uptake. Mannitol has been used clinically to reduce intracranial pressure with varying success, and it is possible that it is more effective in some types of head injury than in others. |
|J Neurosurg. 1985 Jul;63(1):43-8. |
|Effect of mannitol on cerebral blood flow and cerebral perfusion pressure in human head injury[Pubmed: 3925092 ]|
|Patients with severe head injury frequently have evidence of elevated intracranial pressure (ICP) and ischemic neuronal damage at autopsy. Mannitol has been used clinically to reduce ICP with varying success, and it is possible that it is more effective in some types of head injury than in others. |
METHODS AND RESULTS:
The aim of the present study was to determine the effect of Mannitol on ICP, cerebral perfusion pressure (CPP), and cerebral blood flow (CBF) in patients with severe head injury, and to discover if these effects differed in different types of injury. Measurements of CPP, ICP, and CBF were made in 55 patients with severe head injury. In general, the resting level of CBF was higher in patients with diffuse injury (mean 50.2 ml/100 gm/min) than in those with focal injury (mean 39.8 ml/100 gm/min). Mannitol consistently reduced ICP and increased CPP and CBF by 10 to 20 minutes after infusion. The lowest flows (31.8 ml/100 gm/min) were recorded from the most damaged hemispheres of patients with focal injuries and elevated ICP. The baseline levels of flow did not correlate with ICP, CPP, Glasgow Coma Scale score, or outcome. Only four of the 55 patients had a CBF of less than 20 ml/100 gm/min in either or both hemispheres.
The few low CBF's in this and other studies may reflect the steady-state conditions under which measurements are made in intensive care units, and that these patients have entered a phase of reperfusion.
|Eur J Nucl Med Mol Imaging. 2017 Aug 11. |
|Reduction of 68Ga-PSMA renal uptake with mannitol infusion: preliminary results.[Pubmed: 28801787]|
|Urea-based prostate-specific membrane antigen (PSMA) ligands labelled with 68Ga or 177Lu are new tracers with great potential for theranostic approaches in prostate cancer. However, clinical studies have shown that the kidneys are one of the off-target organs along with the salivary and lacrimal glands. In the kidneys, PSMA is physiologically expressed in the apical epithelium of the proximal tubules, and Mannitol acts as an osmotic diuretic in these tubules. |
METHODS AND RESULTS:
We investigated the potential of Mannitol to reduce renal uptake of 68Ga-PSMA. Kidney uptake (SUVmax) was calculated in nine patients undergoing 68Ga-PSMA PET/CT at baseline (b-PET/CT) and after intravenous infusion of 500 ml of 10% Mannitol (m-PET/CT). Two different infusion schemes for Mannitol were used: (1) 500 ml Mannitol was infused over 40 min after 68Ga-PSMA administration (A-infusion) and (2) 250 ml Mannitol was infused over 15 min before and again after 68Ga-PSMA administration (B-infusion). In patients receiving the A-infusion, mean SUVmax increased by 11.9% and 7.4% in the right and left kidney, respectively. In patients receiving the B-infusion, mean SUVmax decreased by 24.3% and 22.4% in the right and left kidney, respectively. Our preliminary findings indicate that Mannitol may play a role in reducing off-target 68Ga-PSMA renal uptake. Administration of the osmotic diuretic should be rapid and start before 68Ga-PSMA injection.
These results warrant dosimetric studies in patients treated with 177Lu-PSMA to find the best scheme for Mannitol administration.
||The herbs of Peucedanum harry-smithii var. subglabrum.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
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* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.