ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
3. Inhibitors
Citing Use of our Products
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock |
10 mM * 1 mL in DMSO / $222.6 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Horticulture Research2020, 7:111. Indian J. of Experimental Bio....2020...Evid Based Complement Alternat Me...2017...Front Aging Neurosci.2019, 11:230Int J Biol Macromol.2018, 112:1093-1103Int J Mol Sci.2015, 16(8):18396-411J Chromatogr B Analyt Technol Bio...2020...Pharm Biol.2017, 55(1):360-366
J Nat Prod.2017, 80(4):854-863The Journal of Agromedicine and M...2018...ACS Nano.2018, 12(4):3385-3396Front Neurosci.2019, 13:1091J Vet Sci.2020, 21(3):e39.Appl. Sci. 2021, 11(10),4666.Wageningen University & Research...2018...Molecules.2021, 26(9):2802.
Molecules.2022, 27(7):2116.Phytomedicine.2021, 2(82):153452Molecules.2021, 26(4):817.Elife.2021, 10:e68058. Fitoterapia.2015, 100:179-86J of Dentistry & Oral Health...2019...Pharmacognosy Journal, 2021, 13(5).
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Our products had been exported to the following research institutions and universities, And still growing.
John Innes Centre (United Kingdom)Institute of Chinese Materia Me... (China)University of Pretoria (South Africa)Medizinische Universit?t Wien (Austria)
Universidad Industrial de Santa... (Colombia)Vin?a Institute of Nuclear Scie... (Serbia)Martin Luther University of Hal... (Germany)VIT University (India)
Institute of Tropical Disease U... (Indonesia)The Australian National University (Australia)Yale University (USA)
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Moracin M
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
J Agric Food Chem.2019, 67(27):7748-7754Toxins (Basel).2020, 12(4):210. Am J Chin Med.2016, 44(8):1719-1735Int. J. Mol. Sci.2022, 23(8), 4130.Nat Prod Sci.2014, 20(3):182-190Korean J Pain.2021, 34(4):405-416.Int J Mol Sci.2021, 22(16):8641.BMC Complement Altern Med.2018, 18(1):221Evid Based Complement Alternat Med.2022, 9767292,2.Int. J. of Food Properties2017, S108-S118
Related Screening Libraries
Description: |
Moracin M is a phytoalexin. Moracin M inhibits PDE4D2, PDE4B2, PDE5A1, and PDE9A2 with the IC(50) values of 2.9, 4.5, >40, and >100 μM, respectively. |
Targets: |
PDE |
In vitro: |
Bioorg Med Chem Lett . 2012 May 1;22(9):3261-4. | Moracin M from Morus alba L. is a natural phosphodiesterase-4 inhibitor[Pubmed: 22483586] | Abstract
Phosphodiesterase-4 (PDE4) has been identified to be a promising target for treatment of asthma. Moracin M extracted from Chinese herbal drug 'Sang-Bai-Pi' (Morus alba L.) was studied for the inhibitory affinity towards PDE4. It inhibited PDE4D2, PDE4B2, PDE5A1, and PDE9A2 with the IC(50) values of 2.9, 4.5, >40, and >100 μM, respectively. Our molecular docking and 8ns molecular dynamics (MD) simulations demonstrated that Moracin M forms three hydrogen bonds with Gln369, Asn321, and Asp318 in the active site and stacks against Phe372. In addition, comparative kinetics analysis of its analog moracin C was carried out to qualitatively validate their inhibitory potency as predicted by the binding free energy calculations after MD simulations. |
|
Moracin M Description
Source: |
The root barks of Morus alba L. |
Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
1 mM |
4.1288 mL |
20.6441 mL |
41.2882 mL |
82.5764 mL |
103.2205 mL |
5 mM |
0.8258 mL |
4.1288 mL |
8.2576 mL |
16.5153 mL |
20.6441 mL |
10 mM |
0.4129 mL |
2.0644 mL |
4.1288 mL |
8.2576 mL |
10.322 mL |
50 mM |
0.0826 mL |
0.4129 mL |
0.8258 mL |
1.6515 mL |
2.0644 mL |
100 mM |
0.0413 mL |
0.2064 mL |
0.4129 mL |
0.8258 mL |
1.0322 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Kinase Assay: |
Bioorg Med Chem Lett. 2012 May 1;22(9):3261-4. | Moracin M from Morus alba L. is a natural phosphodiesterase-4 inhibitor.[Pubmed: 22483586] | Phosphodiesterase-4 (PDE4) has been identified to be a promising target for treatment of asthma. METHODS AND RESULTS: Moracin M extracted from Chinese herbal drug 'Sang-Bai-Pi' (Morus alba L.) was studied for the inhibitory affinity towards PDE4. It inhibited PDE4D2, PDE4B2, PDE5A1, and PDE9A2 with the IC(50) values of 2.9, 4.5, >40, and >100 μM, respectively.
CONCLUSIONS:
Our molecular docking and 8ns molecular dynamics (MD) simulations demonstrated that Moracin M forms three hydrogen bonds with Gln369, Asn321, and Asp318 in the active site and stacks against Phe372. In addition, comparative kinetics analysis of its analog moracin C was carried out to qualitatively validate their inhibitory potency as predicted by the binding free energy calculations after MD simulations. |
|