ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
3. Inhibitors
Citing Use of our Products
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $222.6 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Molecules.2021, 26(2):313.Evid Based Complement Alternat Me...2017...Nutr Res Pract2019, 13:e45Medicinal Chemistry Research ...2021...Pharmacogn Mag.2015, 11(43):562-6J Am Soc Mass Spectrom....2021...Molecules.2022, 27(21):7643. Analytical methods2019, 11(6)
J Ethnopharmacol.2020, 249:112396Plant J.2017, 90(3):535-546Processes 2021, 9(5),894.Phytochemistry Letters2015, 243-247Saudi Pharm J.2019, 27(1):145-153Front. Plant Sci.2022, 13:757852.Appl. Sci.2020, 10(8),2804Recent Pat Anticancer Drug Discov...2022...
Molecules.2019, 24(11):E2044Bull. Pharm. Sci., Assiut Univers...2020...J of Health Science and Alternati...2019...Pharmaceuticals (Basel)....2020...Arch Biochem Biophys.2020, 687:108363.Phytomedicine.2022, 100:154058.Int Immunopharmacol.2020, 90:107268.
More...
Our products had been exported to the following research institutions and universities, And still growing.
Universiti Sains Malaysia (Malaysia)Guangzhou Institutes of Biomedi... (China)Ain Shams University (Egypt)Medical University of South Car... (USA)
University of Minnesota (USA)Chiang Mai University (Thailand)Chinese University of Hong Kong (China)Leibniz Institute of Plant Bioc... (Germany)
Universita' Degli Studi Di Cagl... (Italy)Instytut Nawozów Sztucznych w ... (Poland)University of Sao Paulo (Brazil)
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Moracin M
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Environ Toxicol.2020, doi: 10.1002Chin J Pharm Anal.2019, 39(7):1217-1228Plant J.2017, 90(3):535-546J Exp Bot.2016, 67(12):3777-88J of Advanced Scientific R.2020, 11(3), p109-120.JPC-Journal of Planar Chromatography 2017, 30(4)In Vivo.2022, 36(3):1136-1143. Antioxidants.2022, 11(3):491.Mol Pharmacol.2021, 99(2):163-174.Sci Rep.2018, 8(1)
Related Screening Libraries
| Description: |
Moracin M is a phytoalexin. Moracin M inhibits PDE4D2, PDE4B2, PDE5A1, and PDE9A2 with the IC(50) values of 2.9, 4.5, >40, and >100 μM, respectively. |
| Targets: |
PDE |
| In vitro: |
| Bioorg Med Chem Lett . 2012 May 1;22(9):3261-4. | | Moracin M from Morus alba L. is a natural phosphodiesterase-4 inhibitor[Pubmed: 22483586] | | Abstract
Phosphodiesterase-4 (PDE4) has been identified to be a promising target for treatment of asthma. Moracin M extracted from Chinese herbal drug 'Sang-Bai-Pi' (Morus alba L.) was studied for the inhibitory affinity towards PDE4. It inhibited PDE4D2, PDE4B2, PDE5A1, and PDE9A2 with the IC(50) values of 2.9, 4.5, >40, and >100 μM, respectively. Our molecular docking and 8ns molecular dynamics (MD) simulations demonstrated that Moracin M forms three hydrogen bonds with Gln369, Asn321, and Asp318 in the active site and stacks against Phe372. In addition, comparative kinetics analysis of its analog moracin C was carried out to qualitatively validate their inhibitory potency as predicted by the binding free energy calculations after MD simulations. |
|
Moracin M Description
| Source: |
The root barks of Morus alba L. |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
4.1288 mL |
20.6441 mL |
41.2882 mL |
82.5764 mL |
103.2205 mL |
| 5 mM |
0.8258 mL |
4.1288 mL |
8.2576 mL |
16.5153 mL |
20.6441 mL |
| 10 mM |
0.4129 mL |
2.0644 mL |
4.1288 mL |
8.2576 mL |
10.322 mL |
| 50 mM |
0.0826 mL |
0.4129 mL |
0.8258 mL |
1.6515 mL |
2.0644 mL |
| 100 mM |
0.0413 mL |
0.2064 mL |
0.4129 mL |
0.8258 mL |
1.0322 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
| Kinase Assay: |
| Bioorg Med Chem Lett. 2012 May 1;22(9):3261-4. | | Moracin M from Morus alba L. is a natural phosphodiesterase-4 inhibitor.[Pubmed: 22483586] | Phosphodiesterase-4 (PDE4) has been identified to be a promising target for treatment of asthma.
METHODS AND RESULTS:
Moracin M extracted from Chinese herbal drug 'Sang-Bai-Pi' (Morus alba L.) was studied for the inhibitory affinity towards PDE4. It inhibited PDE4D2, PDE4B2, PDE5A1, and PDE9A2 with the IC(50) values of 2.9, 4.5, >40, and >100 μM, respectively.
CONCLUSIONS:
Our molecular docking and 8ns molecular dynamics (MD) simulations demonstrated that Moracin M forms three hydrogen bonds with Gln369, Asn321, and Asp318 in the active site and stacks against Phe372. In addition, comparative kinetics analysis of its analog moracin C was carried out to qualitatively validate their inhibitory potency as predicted by the binding free energy calculations after MD simulations. |
|
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