Moracin M | CAS:56317-21-6 | Manufacturer ChemFaces

Moracin M

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $222.6 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

Moracin M is a phytoalexin. Moracin M inhibits PDE4D2, PDE4B2, PDE5A1, and PDE9A2 with the IC(50) values of 2.9, 4.5, >40, and >100 μM, respectively.

Targets:

PDE

In vitro:

Bioorg Med Chem Lett . 2012 May 1;22(9):3261-4.

Moracin M from Morus alba L. is a natural phosphodiesterase-4 inhibitor[Pubmed: 22483586]

Abstract Phosphodiesterase-4 (PDE4) has been identified to be a promising target for treatment of asthma. Moracin M extracted from Chinese herbal drug 'Sang-Bai-Pi' (Morus alba L.) was studied for the inhibitory affinity towards PDE4. It inhibited PDE4D2, PDE4B2, PDE5A1, and PDE9A2 with the IC(50) values of 2.9, 4.5, >40, and >100 μM, respectively. Our molecular docking and 8ns molecular dynamics (MD) simulations demonstrated that Moracin M forms three hydrogen bonds with Gln369, Asn321, and Asp318 in the active site and stacks against Phe372. In addition, comparative kinetics analysis of its analog moracin C was carried out to qualitatively validate their inhibitory potency as predicted by the binding free energy calculations after MD simulations.

Moracin M Description

Source:	The root barks of Morus alba L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Bioorg Med Chem Lett. 2012 May 1;22(9):3261-4.

Moracin M from Morus alba L. is a natural phosphodiesterase-4 inhibitor.[Pubmed: 22483586]

Phosphodiesterase-4 (PDE4) has been identified to be a promising target for treatment of asthma.
METHODS AND RESULTS:
Moracin M extracted from Chinese herbal drug 'Sang-Bai-Pi' (Morus alba L.) was studied for the inhibitory affinity towards PDE4. It inhibited PDE4D2, PDE4B2, PDE5A1, and PDE9A2 with the IC(50) values of 2.9, 4.5, >40, and >100 μM, respectively.
CONCLUSIONS:
Our molecular docking and 8ns molecular dynamics (MD) simulations demonstrated that Moracin M forms three hydrogen bonds with Gln369, Asn321, and Asp318 in the active site and stacks against Phe372. In addition, comparative kinetics analysis of its analog moracin C was carried out to qualitatively validate their inhibitory potency as predicted by the binding free energy calculations after MD simulations.

Product Name	Moracin M
Price:	$318 / 5mg
CAS No.:	56317-21-6
Catalog No.:	CFN92327
Molecular Formula:	C₁₄H₁₀O₄
Molecular Weight:	242.2 g/mol
Purity:	>=98%
Type of Compound:	Phenols
Physical Desc.:	Powder
Source:	The root barks of Morus alba L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Anti-inflammatory Compound Library Inhibitors Compound Library Phenols Compound Library PDE Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.1288 mL	20.6441 mL	41.2882 mL	82.5764 mL	103.2205 mL
5 mM	0.8258 mL	4.1288 mL	8.2576 mL	16.5153 mL	20.6441 mL
10 mM	0.4129 mL	2.0644 mL	4.1288 mL	8.2576 mL	10.322 mL
50 mM	0.0826 mL	0.4129 mL	0.8258 mL	1.6515 mL	2.0644 mL
100 mM	0.0413 mL	0.2064 mL	0.4129 mL	0.8258 mL	1.0322 mL

CFN92327	Moracin M	56317-21-6	242.2	C₁₄H₁₀O₄
CFN90794	Mulberroside F	193483-95-3	566.5	C₂₆H₃₀O₁₄
CFN92438	Gnetucleistol C	864763-61-1	256.3	C₁₅H₁₂O₄
CFN92437	Gnetifolin M	439900-84-2	256.3	C₁₅H₁₂O₄
CFN97922	Wittifuran X	1309478-07-6	272.3	C₁₅H₁₂O₅