ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
Citing Use of our Products
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $222.6 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Inflammation.2015, 38(4):1502-16Molecules.2016, 21(6)Polytechnic University of Catalon...2017...Sci Rep. 2017, 12953(7)J Chromatogr A.2017, 1518:46-58Food Res Int.2018, 106:909-919Int J Mol Sci.2018, 19(2)Biofactors.2018, 44(2):168-179
Front Aging Neurosci.2019, 11:230BMC Complement Altern Med....2019...Med Sci Monit.2019, 25:9499-9508Saudi Pharm J.2019, 27(1):145-153Saudi Pharm J2020, 10.1016Food Res Int.2020, 128:108778J Mol Recognit.2020, 33(2):e2819Molecules.2020 ,25(16):3697.
Int J Med Sci.2020, 17(5):626-631Curr Top Med Chem....2020...Analytical sci. & Tech...2020...ACS Omega2020, 5,33,20825-20830BMB Rep.2020, 53(4):218-222.Int Immunopharmacol. 2020, 83:106403.J Nat Med.2021, doi: 10.1007.
Our products had been exported to the following research institutions and universities, And still growing.
Pennsylvania State University (USA)Korea Institute of Oriental Med... (Korea)National Chung Hsing University (Taiwan)Universidad Miguel Hernández (Spain)
Guangzhou Institutes of Biomedi... (China)University of Sao Paulo (Brazil)Deutsches Krebsforschungszentrum (Germany)The Ohio State University (USA)
University of Leipzig (Germany)Funda??o Universitária de Dese... (Brazil)Julius Kühn-Institut (Germany)
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Phytochem Anal.2016, 27(5):296-303Chin. Med.J.Res. Prac.2017, 31(4)Pharmacognosy Magazine2018, 14(56):418-424Food Chem.2019, 274:345-350Nat Plants.2016, 3:16205Front Pharmacol.2017, 8:673Clin Exp Pharmacol Physiol.2020, doi: 10.1111Biochem Biophys Res Commun.2018, 505(1):261-266Food Chem. 2020, 320:126530J Appl Toxicol.2020, 40(7):965-978.
Related Screening Libraries
||Moracin M is a phytoalexin. Moracin M inhibits PDE4D2, PDE4B2, PDE5A1, and PDE9A2 with the IC(50) values of 2.9, 4.5, >40, and >100 μM, respectively. |
Moracin M Description
||The root barks of Morus alba L.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Bioorg Med Chem Lett. 2012 May 1;22(9):3261-4. |
|Moracin M from Morus alba L. is a natural phosphodiesterase-4 inhibitor.[Pubmed: 22483586]|
|Phosphodiesterase-4 (PDE4) has been identified to be a promising target for treatment of asthma. |
METHODS AND RESULTS:
Moracin M extracted from Chinese herbal drug 'Sang-Bai-Pi' (Morus alba L.) was studied for the inhibitory affinity towards PDE4. It inhibited PDE4D2, PDE4B2, PDE5A1, and PDE9A2 with the IC(50) values of 2.9, 4.5, >40, and >100 μM, respectively.
Our molecular docking and 8ns molecular dynamics (MD) simulations demonstrated that Moracin M forms three hydrogen bonds with Gln369, Asn321, and Asp318 in the active site and stacks against Phe372. In addition, comparative kinetics analysis of its analog moracin C was carried out to qualitatively validate their inhibitory potency as predicted by the binding free energy calculations after MD simulations.