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|Size /Price /Stock
||10 mM * 1 mL in DMSO / $270.3 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Nutrients.2020, 12(5):1242.Appl. Sci.2020, 10,1304Acta Agriculturae Scandinavica...2015...Plants (Basel).2021, 10(11):2317. BMC Complement Altern Med....2018...Plant Cell Physiol.2018, 59(1):128-141Cell Physiol Biochem....2017...Int J Mol Sci.2021, 22(19):10405.
Nutrients.2019, 12(1):E40Mol Med Rep.2015, 12(5):7789-95Evid Based Complement Alternat Me...2016...J Sep Sci.2022, 45(18):3556-3566.Pharmacol Rep.2022, 74(1):175-188.Food Funct.2022, doi: 10.1039Rev. Chim.2020, 71(3),558-564Phytomedicine.2018, 40:37-47
Cell Rep.2020, 32(11):108158.Natural Product Communications...2020...Antioxidants (Basel).2020, 9(6):544. Phytomedicine.2018, 38:12-23Int J Mol Sci.2017, 18(12)J Food Biochem.2020, 44(6):e13198. Biomedicines.2022, 10(3):583.
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J Pharmaceutical and Biomedical Analysis2022, 114631.Pharmacol Rep.2022, 74(1):175-188.Life (Basel).2021, 11(7):616. Phytother Res.2018, 32(12):2551-2559Oncol Rep.2021, 46(2):166.Agriculture2022, 12(12), 2173.Int J Mol Sci.2019, 20(21):E5488Molecules.2022, 27(7):2116.Institute of Food Science & Technology2021, 45(9).Huazhong Agricultural University2022, pp34.
Related Screening Libraries
||Moracin P exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1), which is a key mediator during adaptation of cancer cells to tumour hypoxia. Moracin P might protect neuronal cell death against the oxidative stress induced by oxygen-glucose deprivation(OGD), can enhance cell viability in dose-dependent manner against OGD-induced cell death in neuroblastoma SH-SY5Y cells. |
||ROS | HIF | NO|
|Arch Pharm Res. 2011 Aug;34(8):1373-80. |
|Inhibitory effect of 2-arylbenzofurans from the Mori Cortex Radicis (Moraceae) on oxygen glucose deprivation (OGD)-induced cell death of SH-SY5Y cells.[Pubmed: 21910060]|
|Three known 2-arylbenzofurans, Moracin P (1), moracin O (2) and mulberrofuran Q (3) were isolated from the MeOH extract of the Mori Cortex Radicis. |
METHODS AND RESULTS:
These compounds 1-3 enhanced cell viability in dose-dependent manner against oxygen-glucose deprivation (OGD)-induced cell death in neuroblastoma SH-SY5Y cells, which was measured by MTT reduction assay. (EC(50) values of 10.4, 12.6, and 15.9 μM, respectively). In addition, the compounds 1-3 were examined for their inhibitory effect on OGD-induced ROS production by FACS analysis. We observed these compounds reduced ROS production in OGD-induced cell death (IC(50) values of 1.9, 0.3 and 12.1 μM, respectively). Consequently, reactive oxygen species (ROS) were overexpressed in OGD-induced cells and all three compounds reduced ROS induced by OGD in dosedependent manner.
Taken together, compounds 1-3 might protect neuronal cell death against the oxidative stress induced by OGD, though further studies in vitro and in vivo models are necessary.
|Molecules. 2011 Jul 19;16(7):6010-22. |
|Inhibitory effects of constituents from Morus alba var. multicaulis on differentiation of 3T3-L1 cells and nitric oxide production in RAW264.7 cells.[Pubmed: 21772233]|
|A new arylbenzofuran, 3',5'-dihydroxy-6-methoxy-7-prenyl-2-arylbenzofuran (1), and 25 known compounds, including moracin R (2), moracin C (3), moracin O (4), Moracin P (5), artoindonesianin O (6), moracin D (7), alabafuran A (8), mulberrofuran L (9), mulberrofuran Y (10), kuwanon A (11), kuwanon C (12), kuwanon T (13), morusin (14), kuwanon E (15), sanggenon F (16), betulinic acid (17), uvaol (18), ursolic acid (19), β-sitosterol (20), oxyresveratrol 2-O-β-D-glucopyranoside (21), mulberroside A (22), mulberroside B (23), 5,7-dihydroxycoumarin 7-O-β-D-glucopyranoside (24), 5,7-dihydroxycoumarin 7-O-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranoside (25) and adenosine (26), were isolated from Morus alba var. multicaulis Perro. (Moraceae).
METHODS AND RESULTS:
Their structures were determined by spectroscopic methods. The prenyl-flavonoids 11-14, 16, triterpenoids 17,18 and 20 showed significant inhibitory activity towards the differentiation of 3T3-L1 adipocytes.
The arylbenzofurans 1-10 and prenyl-flavonoids 11-16 also showed significant nitric oxide (NO) production inhibitory effects in RAW264.7 cells.
Moracin P Description
||The root barks of Morus alba L.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Chem Commun (Camb). 2009 Apr 14;(14):1879-81. |
|The first total synthesis of moracin O and moracin P, and establishment of the absolute configuration of moracin O.[Pubmed: 19319432]|
|The first total synthesis of the naturally occurring benzofurans, moracin O and Moracin P was achieved using a Sonogashira cross coupling reaction followed by in situ cyclization, and the absolute configuration of natural moracin O was established.|
|Eur J Med Chem. 2011 Jun;46(6):2386-96. |
|HIF-1α inhibitors: synthesis and biological evaluation of novel moracin O and P analogues.[Pubmed: 21481991]|
|The natural products moracin O and Moracin P exhibited potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1), which is a key mediator during adaptation of cancer cells to tumour hypoxia.
METHODS AND RESULTS:
Systematic variations of the structures of benzofuran type moracins were made and structure-activity relationship analysis showed the importance of the 2-arylbenzofuran ring and the (R)-configuration of the core scaffold.
Further evaluation of the representative compound 5 showed its inhibitory effect on HIF-1α protein accumulation and target gene expression under hypoxia.
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