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3. Inhibitors
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $288 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
JEJU National University2022, 10478.Antioxidants2022, 11(2),234.Oncotarget.2016, 8(51):88386-88400J Ethnopharmacol.2020, 269:113752. Mol Med Rep.2022, 26(4):299.Curr Eye Res.2018, 43(1):27-34Clin Exp Pharmacol Physiol....2020...Pharmaceuticals (Basel)....2021...
Toxins (Basel).2020, 12(4):210. South African Journal of Botany...2021...Aquaculture2017, 481:94-102Antioxidants (Basel)....2021...Evid Based Complement Alternat Me...2021...Molecules.2019, 24(10):E1930Phytomedicine.2015, 22(14):1262-8J Nat Med.2017, 71(2):380-388
Biomed Pharmacother.2021, 144:112300.Phytother Res.2018, 32(5):923-932J Basic Clin Physiol Pharmacol....2016...J Hepatocell Carcinoma....2022...Industrial Crops and Products...2021...Evid Based Complement Alternat Me...2021...Plant Methods.2017, 13:108
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Our products had been exported to the following research institutions and universities, And still growing.
University of Brasilia (Brazil)University of British Columbia (Canada)Hamdard University (India)Charles Sturt University (Denmark)
University of Canterbury (New Zealand)Colorado State University (USA)Universiti Kebangsaan Malaysia (Malaysia)Max Rubner-Institut (MRI) (Germany)
Osmania University (India)Nanjing University of Chinese M... (China)Chang Gung University (Taiwan)
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Morusinol
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manager@chemfaces.com
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service@chemfaces.com
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+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Journal of Applied Pharmaceutical Science2022, 0(00), pp:001-007Antioxidants (Basel).2022, 11(12):2411. Current Traditional Medicine, 2021, 7:326-335(10).South African Journal of Botany2021, 142:114-123.Pharmaceuticals.2022, 15(4), 402.PLoS One.2022, 17(4):e0267007. World J Mens Health.2019, 10.5534J Funct Foods2019, 54:449-456Journal of Functional Foods2019, 52:430-441Appl. Sci.2020, 10(23), 8729
Related Screening Libraries
| Description: |
Morusinol may significantly inhibit arterial thrombosis in vivo due to antiplatelet activity, may exert beneficial effects on transient ischemic attacks or stroke via the modulation of platelet activation. |
| Targets: |
IL Receptor | TNF-α | NF-kB |
| In vivo: |
| J Atheroscler Thromb. 2012;19(6):516-22. | | Morusinol extracted from Morus alba inhibits arterial thrombosis and modulates platelet activation for the treatment of cardiovascular disease.[Pubmed: 22472211] | Morus alba (white mulberry) has been used in traditional Chinese medicine as an anti-headache, diuretic, expectorant, and anti-diabetic agent. In previous studies, extracts of Morus alba demonstrated favorable biological properties, such as antioxidant activity, suppression of lipoxygenase (LOX)-1, cytotoxicity against cancer cells, and inhibition of the invasion and migration of cancer cells.
This study further evaluated the effects of Morusinol, a flavonoid derived from Morus alba root bark, on platelet aggregation and thromboxane B(2) (TXB(2) formation in vitro and thrombus formation in vivo.
METHODS AND RESULTS:
The antiplatelet potential of Morusinol was measured using in vitro rabbit platelet aggregation and TXB(2) formation assays. Arterial thrombus formation was investigated using an in vivo ferric chloride (FeCl(3)-induced thrombosis model.
Morusinol significantly inhibited collagen- and arachidonic acid-induced platelet aggregation and TXB(2) formation in cultured platelets in a concentration-dependent manner. Thrombus formation was reduced by 32.1, 42.0, and 99.0% for collagen-induced TXB(2) formation, and 8.0, 24.1, and 29.2% for arachadonic acid-induced TXB(2) formation, with 5, 10, and 30 μg/mL Morusinol, respectively. Moreover, oral Morusinol (20 mg/kg) or aspirin (20 mg/kg) for three days significantly increased the time to occlusion in vivo by 20.3±5.0 or 6.8±2.9 min, respectively, compared with the control (1% CMC, carboxymethyl cellulose).
CONCLUSIONS:
Taken together, these results indicate that Morusinol may significantly inhibit arterial thrombosis in vivo due to antiplatelet activity. Thus, Morusinol may exert beneficial effects on transient ischemic attacks or stroke via the modulation of platelet activation. |
|
Morusinol Description
| Source: |
The root barks of Morus alba L. |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
2.2805 mL |
11.4025 mL |
22.805 mL |
45.61 mL |
57.0125 mL |
| 5 mM |
0.4561 mL |
2.2805 mL |
4.561 mL |
9.122 mL |
11.4025 mL |
| 10 mM |
0.2281 mL |
1.1403 mL |
2.2805 mL |
4.561 mL |
5.7013 mL |
| 50 mM |
0.0456 mL |
0.2281 mL |
0.4561 mL |
0.9122 mL |
1.1403 mL |
| 100 mM |
0.0228 mL |
0.114 mL |
0.2281 mL |
0.4561 mL |
0.5701 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
| Cell Research: |
| J Nat Prod. 2014 Jun 27;77(6):1297-303. | | Evaluation of anti-inflammatory activity of prenylated substances isolated from Morus alba and Morus nigra.[Pubmed: 24901948] | Chromatographic separation of root extracts of Morus alba and M. nigra led to the identification of the 2-arylbenzofurans moracin C (1), mulberrofuran Y (2), and mulberrofuran H (3), and the prenylated flavonoids kuwanon E (4), kuwanon C (5), sanggenon H (6), cudraflavone B (7), and Morusinol (8), and the Diels-Alder adducts soroceal (9), and sanggenon E (10).
METHODS AND RESULTS:
The cytotoxicity and their antiphlogistic activity, determined as the attenuation of the secretion of TNF-α and IL-1β and the inhibition of NF-κB nuclear translocation in LPS-stimulated macrophages, were evaluated for compounds 1-10. |
|
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