Norwogonin | CAS:4443-09-8 | Manufacturer ChemFaces

Norwogonin

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Product Name	Norwogonin
Price:	$318 / 20mg
CAS No.:	4443-09-8
Catalog No.:	CFN92218
Molecular Formula:	C₁₅H₁₀O₅
Molecular Weight:	270.2 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Yellow powder
Source:	The roots of Scutellaria baicalensis Georgi
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $64.5 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

Norwogonin(IC 50 = 1.1 microM) shows potent inhibitory activity toward VHR.

Targets:

VHR

In vitro:

Biomol Ther (Seoul) . 2016 Sep 1;24(5):552-8.

Inhibitory Effects of Norwogonin, Oroxylin A, and Mosloflavone on Enterovirus 71[Pubmed: 27257010]

Abstract Severe complications associated with EV71 infections are a common cause of neonatal death. Lack of effective therapeutic agents for these infections underlines the importance of research for the development of new antiviral compounds. In the present study, the anti-EV71 activity of Norwogonin, oroxylin A, and mosloflavone from Scutellaria baicalensis Georgi was evaluated using a cytopathic effect (CPE) reduction method, which demonstrated that all three compounds possessed strong anti-EV71 activity and decreased the formation of visible CPEs. Norwogonin, oroxylin A, and mosloflavone also inhibited virus replication during the initial stage of virus infection, and they inhibited viral VP2 protein expression, thereby inhibiting viral capsid protein synthesis. However, ribavirin has a relatively weaker efficacy compared to the other drugs. Therefore, these findings provide important information that will aid in the utilization of Norwogonin, oroxylin A, and mosloflavone for EV71 treatment. Keywords: Antiviral activity; Enterovirus 71; Mosloflavone; Norwogonin; Oroxylin A.

Norwogonin Description

Source:	The roots of Scutellaria baicalensis Georgi
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Planta Med. 2002 Dec;68(12):1063-5.

Inhibition of VHR dual-specificity protein tyrosine phosphatase activity by flavonoids isolated from Scutellaria baicalensis: structure-activity relationships.[Pubmed: 12494330]

Three flavonoids: Norwogonin, dihydroNorwogonin and baicalein, were isolated from the roots of Scutellaria baicalensis, as potential inhibitors of VHR dual-specificity protein tyrosine phosphatase (DS-PTPase).
METHODS AND RESULTS:
Norwogonin (IC 50 = 1.1 microM), dihydroNorwogonin (IC 50 = 2.9 microM) and baicalein (IC 50 = 2.4 microM) showed potent inhibitory activity toward VHR, but had no inhibitory activity against T-cell protein tyrosine phosphatase or serine/threonine protein phosphatase 1.
CONCLUSIONS:
From comparisons to the inhibitory activities of other similar flavonoids, it could be suggested that the presence of a hydroxy group in the B ring of flavonoids interferes with the inhibitory activity toward VHR DS-PTPase.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antioxidants Compound Library Antiviral Compound Library Cytotoxic Compound Library Flavonoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.701 mL	18.5048 mL	37.0096 mL	74.0192 mL	92.5241 mL
5 mM	0.7402 mL	3.701 mL	7.4019 mL	14.8038 mL	18.5048 mL
10 mM	0.3701 mL	1.8505 mL	3.701 mL	7.4019 mL	9.2524 mL
50 mM	0.074 mL	0.3701 mL	0.7402 mL	1.4804 mL	1.8505 mL
100 mM	0.037 mL	0.185 mL	0.3701 mL	0.7402 mL	0.9252 mL

CFN97535	5-Hydroxy-7-acetoxy-8-methoxyflavone	95480-80-1	326.3	C₁₈H₁₄O₆
CFN98240	5,7-Diacetoxy-8-methoxyflavone	23246-80-2	368.3	C₂₀H₁₆O₇
CFN98475	Moslosooflavone	3570-62-5	298.3	C₁₇H₁₄O₅
CFN91074	Norwogonin 5,7,8-trimethyl ether	23050-38-6	312.3	C₁₈H₁₆O₅
CFN98783	Baicalein	491-67-8	270.2	C₁₅H₁₀O₅
CFN98540	Oroxylin A	480-11-5	284.26	C₁₆H₁₂O₅
CFN91886	Negletein	29550-13-8	284.26	C₁₆H₁₂O₅
CFN90893	Mosloflavone	740-33-0	298.3	C₁₇H₁₄O₅
CFN95009	6-Hydroxywogonin	76844-70-7	300.3	C₁₆H₁₂O₆
CFN98403	6-Methoxywogonin	3162-45-6	314.3	C₁₇H₁₄O₆