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    Natural Products
    Norwogonin
    Information
    CAS No. 4443-09-8 Price $388 / 10mg
    Catalog No.CFN92218Purity>=98%
    Molecular Weight270.2Type of CompoundFlavonoids
    FormulaC15H10O5Physical DescriptionYellow powder
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $176.5 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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    Norwogonin

    Norwogonin
    Product Name Norwogonin
    CAS No.: 4443-09-8
    Catalog No.: CFN92218
    Molecular Formula: C15H10O5
    Molecular Weight: 270.2 g/mol
    Purity: >=98%
    Type of Compound: Flavonoids
    Physical Desc.: Yellow powder
    Targets: VHR
    Source: The roots of Scutellaria baicalensis Georgi
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $388 / 10mg
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  • Faculty of Chem. & Nat. Resource Eng.2014, 62
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  • Biological Activity
    Description: Norwogonin(IC 50 = 1.1 microM) shows potent inhibitory activity toward VHR.
    Targets: VHR
    Norwogonin Description
    Source: The roots of Scutellaria baicalensis Georgi
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.701 mL 18.5048 mL 37.0096 mL 74.0192 mL 92.5241 mL
    5 mM 0.7402 mL 3.701 mL 7.4019 mL 14.8038 mL 18.5048 mL
    10 mM 0.3701 mL 1.8505 mL 3.701 mL 7.4019 mL 9.2524 mL
    50 mM 0.074 mL 0.3701 mL 0.7402 mL 1.4804 mL 1.8505 mL
    100 mM 0.037 mL 0.185 mL 0.3701 mL 0.7402 mL 0.9252 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Kinase Assay:
    Planta Med. 2002 Dec;68(12):1063-5.
    Inhibition of VHR dual-specificity protein tyrosine phosphatase activity by flavonoids isolated from Scutellaria baicalensis: structure-activity relationships.[Pubmed: 12494330]
    Three flavonoids: Norwogonin, dihydroNorwogonin and baicalein, were isolated from the roots of Scutellaria baicalensis, as potential inhibitors of VHR dual-specificity protein tyrosine phosphatase (DS-PTPase).
    METHODS AND RESULTS:
    Norwogonin (IC 50 = 1.1 microM), dihydroNorwogonin (IC 50 = 2.9 microM) and baicalein (IC 50 = 2.4 microM) showed potent inhibitory activity toward VHR, but had no inhibitory activity against T-cell protein tyrosine phosphatase or serine/threonine protein phosphatase 1.
    CONCLUSIONS:
    From comparisons to the inhibitory activities of other similar flavonoids, it could be suggested that the presence of a hydroxy group in the B ring of flavonoids interferes with the inhibitory activity toward VHR DS-PTPase.
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