ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
Citing Use of our Products
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Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $176.5 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Scientific World Journal....2014...Am J Chin Med.2016, 44(6):1255-1271Braz J Med Biol Res. 2016, 49(7)Chin. Med.J.Res. Prac.2017, 31(4)Food Chem.2018, 262:78-85Phytother Res.2018, 32(5):923-932Phytomedicine.2018, 40:37-47Chemistry of Natural Compounds...2018...
Chemistry of Plant Materials....2019...Molecules.2019, 24(11):E2044Nat Prod Sci.2019, 25(3):238Biochem Biophys Res Commun....2019...Sci Rep.2020, 10:4495(2020)Int J Med Sci.2020, 17(5):626-631J Med Food.2020, 23(6):633-640.Molecules.2020, 25(15):3353.
Bioorg Med Chem.2020, 28(12):115553.Cell Rep.2020, 32(11):108158.Food Chem.2020, 327:126992.Environ Toxicol.2020, doi: 10.1002Chung Shan Medical University...2020...Naunyn Schmiedebergs Arch Pharmac...2021...J Nat Med.2021, doi: 10.1007.
Our products had been exported to the following research institutions and universities, And still growing.
University of Illinois (USA)Uniwersytet Gdański (Poland)Medizinische Universit?t Wien (Austria)Universidade da Beira Interior (Germany)
Seoul National University of Sc... (Korea)University of Wisconsin-Madison (USA)Universitas islam negeri Jakarta (Indonesia)Monash University Sunway Campus (Malaysia)
Rio de Janeiro State University (Brazil)Auburn University (USA)University of Hull (United Kingdom)
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Faculty of Chem. & Nat. Resource Eng.2014, 62Phytomedicine.2015, 22(4):498-503Clin Exp Pharmacol Physiol.2015, 42(11):1189-97Arch Biochem Biophys.2018, 644:93-99Semyung University2017, 149407BMC Complement Altern Med.2019, 19(1):325Molecules.2020, 25(23):5636.Food Chem.2018, 262:78-85Oncotarget.2017, 9(3):4161-4172Evid Based Complement Alternat Med.2015, 2015:165457
Related Screening Libraries
||Norwogonin(IC 50 = 1.1 microM) shows potent inhibitory activity toward VHR.|
||The roots of Scutellaria baicalensis Georgi
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Planta Med. 2002 Dec;68(12):1063-5. |
|Inhibition of VHR dual-specificity protein tyrosine phosphatase activity by flavonoids isolated from Scutellaria baicalensis: structure-activity relationships.[Pubmed: 12494330]|
|Three flavonoids: Norwogonin, dihydroNorwogonin and baicalein, were isolated from the roots of Scutellaria baicalensis, as potential inhibitors of VHR dual-specificity protein tyrosine phosphatase (DS-PTPase). |
METHODS AND RESULTS:
Norwogonin (IC 50 = 1.1 microM), dihydroNorwogonin (IC 50 = 2.9 microM) and baicalein (IC 50 = 2.4 microM) showed potent inhibitory activity toward VHR, but had no inhibitory activity against T-cell protein tyrosine phosphatase or serine/threonine protein phosphatase 1.
From comparisons to the inhibitory activities of other similar flavonoids, it could be suggested that the presence of a hydroxy group in the B ring of flavonoids interferes with the inhibitory activity toward VHR DS-PTPase.