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    Natural Products
    Ombuin
    Information
    CAS No. 529-40-8 Price
    Catalog No.CFN98876Purity>=98%
    Molecular Weight330.3 Type of CompoundFlavonoids
    FormulaC17H14O7Physical DescriptionYellow powder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
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    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
  • Universidade de Franca (Brazil)
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  • Deutsches Krebsforschungszentrum (Germany)
  • Macau University of Science and... (China)
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  • Guangzhou Institutes of Biomedi... (China)
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  • Package
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    Ombuin

    Ombuin
    Product Name Ombuin
    CAS No.: 529-40-8
    Catalog No.: CFN98876
    Molecular Formula: C17H14O7
    Molecular Weight: 330.3 g/mol
    Purity: >=98%
    Type of Compound: Flavonoids
    Physical Desc.: Yellow powder
    Targets: NO | IFN-纬 | IL Receptor | TNF-伪
    Source: The heartwoods of Caesalpinia sappan L.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price:
    Inquire / Order: manager@chemfaces.com
    Technical Inquiries: service@chemfaces.com
    Tel: +86-27-84237783
    Fax: +86-27-84254680

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    1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
  • Plants (Basel).2021, 10(4):702.
  • Int J Mol Sci.2019, 21(1):E265
  • Life Sci.2018, 209:498-506
  • Molecules.2019, 24(6):E1177
  • Biomed Chromatogr.2019, 8:e4774
  • Medicina (Kaunas).2020, 56(12):685.
  • Phytother Res.2016, 30(12):2020-2026
  • Pharmaceutics.2021, 13(11):1839.
  • Biomed Sci Letters.2020, 26:319-326
  • Front Pharmacol.2018, 9:756
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Anti-inflammatory Compound Library
  • Flavonoids Compound Library
  • TNF-α Inhibitor Library
  • NO Inhibitor Library
  • IL Receptor Inhibitor Library
  • IFN-γ Inhibitor Library
  • Biological Activity
    Description: Ombuin has anti-inflammary activity, it inhibits some macrophage functions involved in the inflammatory process. Ombuin significantly and dose dependently inhibits lipopolysaccharide (LPS) and interferon (IFN)-gamma induced nitric oxide (NO), and cytokines [tumor necrosis factor (TNF)-alpha and interleukin (IL)-12].
    Targets: NO | IFN-γ | IL Receptor | TNF-α
    In vitro:
    Phytother Res. 2008 Jul;22(7):957-62.
    Antiinflammatory activities of flavonoids and a triterpene caffeate isolated from Bauhinia variegata.[Pubmed: 18384188]
    In the continuing search for novel antiinflammatory agents, six flavonoids, namely kaempferol (1), Ombuin (2), kaempferol 7,4'-dimethyl ether 3-O-beta-D-glucopyranoside (3), kaempferol 3-O-beta-D-glucopyranoside (4), isorhamnetin 3-O-beta-D-glucopyranoside (5) and hesperidin (6), together with one triterpene caffeate, 3beta-trans-(3,4-dihydroxycinnamoyloxy)olean-12-en-28-oic acid (7) were isolated from the non-woody aerial parts of Bauhinia variegata.
    METHODS AND RESULTS:
    Compounds 1-7 were evaluated as inhibitors of some macrophage functions involved in the inflammatory process. These seven compounds significantly and dose dependently inhibited lipopolysaccharide (LPS) and interferon (IFN)-gamma induced nitric oxide (NO), and cytokines [tumor necrosis factor (TNF)-alpha and interleukin (IL)-12]. The concentration causing a 50% inhibition (IC50) of NO, TNF-alpha and IL-12 production by compounds 1, 2 and 7 was approximately 30, 50 and 10 microM, respectively, while at 50, 200 and 40 microM compounds 3, 4, and 5, 6 showed 15-30% inhibition, respectively. On the other hand, compounds 3 and 7 showed no inhibitory effect, while compounds 1, 4-6 reduced by around 10-30% the synthesis of NO by macrophages, when inducible NO synthase was already expressed with LPS/IFN-gamma for 24 h.
    CONCLUSIONS:
    These experimental findings lend pharmacological support to the suggested folkloric uses of the plant B. variegata in the management of inflammatory conditions.
    Planta Med. 1998 Jun;64(5):464-6.
    Licochalcone A: an inducer of cell differentiation and cytotoxic agent from Pogostemon cablin.[Pubmed: 9690352]
    Licochalcone A (1), Ombuin (2), and 5,7-dihydroxy-3',4'-dimethoxyflavanone (3) were isolated from the aerial parts of Pogostemon cablin by cytotoxicity-guided fractionation.
    METHODS AND RESULTS:
    Compound 1 showed in vitro cytotoxicity and Pl-PLC gamma 1 inhibition activity. Treatment of promyelocytic leukemia cells (HL-60) with compound 1 induced terminal differentiation with the generation of monocyte using nonspecific acid esterase assay.
    Ombuin Description
    Source: The heartwoods of Caesalpinia sappan L.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.0276 mL 15.1378 mL 30.2755 mL 60.551 mL 75.6888 mL
    5 mM 0.6055 mL 3.0276 mL 6.0551 mL 12.1102 mL 15.1378 mL
    10 mM 0.3028 mL 1.5138 mL 3.0276 mL 6.0551 mL 7.5689 mL
    50 mM 0.0606 mL 0.3028 mL 0.6055 mL 1.211 mL 1.5138 mL
    100 mM 0.0303 mL 0.1514 mL 0.3028 mL 0.6055 mL 0.7569 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Narcissoside

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    Arteannuin B

    Catalog No: CFN98807
    CAS No: 50906-56-4
    Price: $228/20mg
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    Catalog No: CFN90856
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    Price: $388/5mg
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    Catalog No: CFN92207
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    Price: $268/10mg
    Cimicidanol 3-O-alpha-L-arabinoside

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