Palbinone | CAS:139954-00-0 | Manufacturer ChemFaces

Palbinone

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Palbinone Description

Source:	The roots of Paeonia lactiflora Pall.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Phytother Res. 2014 Feb;28(2):308-11.

Palbinone from Paeonia suffruticosa protects hepatic cells via up-regulation of heme oxygenase-1.[Pubmed: 23595773]

Paeonia suffruticosa has been traditionally employed for vitalizing blood circulation and alleviating liver and inflammatory diseases.
METHODS AND RESULTS:
The pathways by which Palbinone (PB) isolated from P. suffruticosa mediates heme oxygenase-1 (HO-1) induction were investigated using the specific inhibitors for PI3K and mitogen activated protein kinases pathways. The effect of Palbinone -treatment on Nrf2 translocalization and HO-1-antioxidant response element (ARE) regulation was examined employing Western blot and luciferase assays. Palbinone induced HO-1 expression via the activation of Nrf2 in the hepatic cells, and ARE-dependent genes were stimulated via the Palbinone -mediated Nrf2 activation. Palbinone -mediated HO-1 expression could be involved with PI3K/Akt and ERK1/2 pathways.
CONCLUSIONS:
Our study suggests the mechanism by which Palbinone induces HO-1 expression in the hepatic cells. This might substantiate the traditional applications of P. suffruticosa for the treatment of oxidative stress-related diseases including oxidant and inflammatory-mediated vascular and liver diseases.

Structure Identification:

Chem Pharm Bull (Tokyo). 1993 Mar;41(3):487-90.

Palbinone, a novel terpenoid from Paeonia albiflora; potent inhibitory activity on 3 alpha-hydroxysteroid dehydrogenase.[Pubmed: 8477499]

METHODS AND RESULTS:
Palbinone, a novel terpenoid isolated from the roots of Paeonia albiflora, showed a strong inhibitory activity on the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH)-linked 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSD) of rat liver cytosol.
CONCLUSIONS:
The structures of Palbinone and a known compound, paeonilactone-B isolated from the active fraction of this plant were determined by the use of 2D NMR techniques (1H-1H COSY, 1H-13C COSY, 1H-13C long-range COSY, and HMBC).

Product Name	Palbinone
Price:
CAS No.:	139954-00-0
Catalog No.:	CFN96019
Molecular Formula:	C₂₂H₃₀O₄
Molecular Weight:	358.5 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Orange powder
Source:	The roots of Paeonia lactiflora Pall.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Anti-diabetic Compound Library Triterpenoids Compound Library PI3K Inhibitor Library Nrf2 Inhibitor Library NADPH-oxidase Inhibitor Library HO-1 Inhibitor Library ERK Inhibitor Library Akt Inhibitor Library

Description:	Palbinone can induce HO-1 expression in the hepatic cells. It shows a strong inhibitory activity on the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH)-linked 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSD) of rat liver cytosol.
Targets:	HO-1 \| Nrf2 \| PI3K \| Akt \| ERK \| NADPH-oxidase

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.7894 mL	13.947 mL	27.894 mL	55.788 mL	69.735 mL
5 mM	0.5579 mL	2.7894 mL	5.5788 mL	11.1576 mL	13.947 mL
10 mM	0.2789 mL	1.3947 mL	2.7894 mL	5.5788 mL	6.9735 mL
50 mM	0.0558 mL	0.2789 mL	0.5579 mL	1.1158 mL	1.3947 mL
100 mM	0.0279 mL	0.1395 mL	0.2789 mL	0.5579 mL	0.6974 mL

CFN96019	Palbinone	139954-00-0	358.5	C₂₂H₃₀O₄
CFN96254	Dammarenediol II 3-O-caffeate	171438-55-4	606.9	C₃₉H₅₈O₅
CFN98705	Dipterocarpol	471-69-2	442.7	C₃₀H₅₀O₂
CFN97232	20,24-Dihydroxydammar-25-en-3-one	75069-59-9	458.7	C₃₀H₅₀O₃
CFN97092	24,25-Epoxydammar-20(21)-en-3-one	63543-52-2	440.7	C₃₀H₄₈O₂
CFN98922	Dammar-20(21)-en-3,24,25-triol	55050-69-6	460.7	C₃₀H₅₂O₃
CFN97093	24,25-Dihydroxydammar-20-en-3-one	63543-53-3	458.7	C₃₀H₅₀O₃
CFN90349	25(R)-Hydroxyprotopanaxadiol	83349-37-5	478.75	C₃₀H₅₄O₄
CFN90351	25(S)-Hydroxyprotopanaxatriol	113539-03-0	494.75	C₃₀H₅₄O₅
CFN99717	Gypenoside XLIX	94987-08-3	1047.23	C₅₂H₈₆O₂₁