ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
3. Inhibitors
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $97.3 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Phytomedicine.2015, 22(4):498-503Food Science and Biotechnology...2015...Mediators Inflamm. 2016, 2016:6189590Srinagarind Medical Journal2017, 32(1)Aquaculture2017, 481:94-102Int J Mol Sci.2018, 19(9):E2528Life Sci.2018, 209:498-506Phytomedicine.2018, 38:45-56
Virulence.2018, 9(1):588-603Industrial Crops and Products...2019...J Adv Res.2019, 17:85-94Molecules.2019, 24(11):E2044Molecules.2019, 24(11):E2102Molecules.2019, 24(16):E3003Nutrients2020, 12(2):488Front Immunol. 2020, 11:62.
J Chromatogr B Analyt Technol Bio...2020...Int J Biol Macromol....2020...Applied Biological Chem. 2020, 26(63).J Biomed Sci.2020, 27(1):60.Anal Bioanal Chem....2020...Chemistry of Natural Compounds...2020...Applied Biological Chemistry...2020...
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Our products had been exported to the following research institutions and universities, And still growing.
University of Wuerzburg (Germany)Molecular Biology Institute of ... (Spain)Max Rubner-Institut (MRI) (Germany)Technical University of Denmark (Denmark)
University of Leipzig (Germany)Universita' Degli Studi Di Cagl... (Italy)Universidad de La Salle (Mexico)Kyung Hee University (Korea)
National Cancer Institute (USA)Harvard University (USA)Griffith University (Australia)
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Polygalacic acid
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Chin J Appl. Physiol.2019, 35(3):283-288Proc Natl Acad Sci USA.2016, 113(30):E4407-1Drug Des Devel Ther.2020, 14:969-976.Chemistry of Vegetable Raw Materials2019, 3:119-127Korean Herb. Med. Inf.2020, 8(2):205-213J Microbiol Biotechnol.2020, 30(2):178-186.Plants (Basel).2020, 9(11):1535.Industrial Food Engineering2015, 19(4):408-413Evid Based Complement Alternat Med.2018, 2018:8565132Int J Mol Sci.2019, 20(23):E6071
Related Screening Libraries
| Description: |
Polygalacic acid may exert a significant neuroprotective effect on cognitive impairment, driven in part by the modulation of cholinergic activity and neuroinflammation. Polygalacic acid shows significant postingestive effects on Spodoptera littoralis larvae. |
| Targets: |
AChR | Immunology & Inflammation related |
| In vitro: |
| J Nat Prod. 2010 Nov 29;73(11):1863-7. | | Antiproliferative effects of saponins from the roots of Platycodon grandiflorum on cultured human tumor cells.[Pubmed: 20939516] |
METHODS AND RESULTS:
Three new triterpenoid saponins, platyconic acid B lactone (1), deapio-platyconic acid B lactone (2), and deapio-platycodin D(2) (3), together with 17 known triterpenoid saponins, were isolated from a root extract of Platycodon grandiflorum. The structures of 1-3 were determined on the basis of spectroscopic data interpretation and chemical transformation.
CONCLUSIONS:
Saponins with a platycodigenin or Polygalacic acid unit as a sapogenin demonstrated significant inhibitory effects on the proliferation of a small panel of cultured human tumor cells. | | Phytochemistry. 2011 Jun;72(8):743-51. | | Bioactive saponins from Microsechium helleri and Sicyos bulbosus.[Pubmed: 21439597 ] | Eleven oleanane-type saponins (1-11) have been isolated from Microsechium helleri and Sicyos bulbosus roots and were evaluated for their antifeedant, nematicidal and phytotoxic activities.
METHODS AND RESULTS:
Saponins {3-O-β-D-glucopyranosyl (1→3)-β-D-glucopyranosyl-2β,3β,16α,23-tetrahydroxyolean-12-en-28-oic acid 28-O-α-L-rhamnopyranosyl-(1→3)-β-D-xylopyranosyl-(1→4)-[β-D-xylopyranosyl-(1→3)]-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranoside} (1), and {3-O-β-D-glucopyranosyl-2β,3β,16α,23-tetrahydroxyolean-12-en-28-oic acid 28-O-α-L-rhamnopyranosyl-(1→3)-β-D-xylopyranosyl-(1→4)-[β-D-xylopyranosyl-(1→3)]-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranoside} (2) were also isolated from M. helleri roots together with the two known compounds 3 and 4. Seven known structurally related saponins (5-11) were isolated from S. bulbosus roots. The structures of these compounds were established as bayogenin and polygalacic glycosides using one- and two-dimensional NMR spectroscopy and mass spectrometry. Compounds 7, 10, bayogenin (12) and Polygalacic acid (13) showed significant (p<0.05) postingestive effects on Spodoptera littoralis larvae, compounds 5-11 and 12 showed variable nematicidal effects on Meloydogyne javanica and all tested saponins had variable phytotoxic effects on several plant species (Lycopersicum esculentum, Lolium perenne and Lactuca sativa).
CONCLUSIONS:
These are promising results in the search for natural pesticides from the Cucurbitaceae family. |
|
| In vivo: |
| Phytomedicine. 2016 Feb 15;23(2):149-55. | | Neuroprotective effects of polygalacic acid on scopolamine-induced memory deficits in mice.[Pubmed: 26926176 ] | Polygala tenuifolia Willd is a Traditional Chinese Medicine used for the treatment of learning and memory deficits.
METHODS AND RESULTS:
Triterpenoid saponins, the main bioactive compounds of Polygala tenuifolia Willd, are easily hydrolyzed to Polygalacic acid (PA).Treatment with scopolamine significantly increased the escape latency time, decreased the number of crossings, and shortened the time spent in the target quadrant, while PA reversed these scopolamine-induced effects. PA significantly improved cholinergic system reactivity, as indicated by decreased acetylcholinesterase (AChE) activity, increased choline acetyltransferase (ChAT) activity, and elevated levels of acetylcholine (ACh) in the hippocampus and frontal cortex. PA also significantly ameliorated neuroinflammation and oxidative stress in mice.
CONCLUSIONS:
These results suggest that PA might exert a significant neuroprotective effect on cognitive impairment, driven in part by the modulation of cholinergic activity and neuroinflammation. |
|
Polygalacic acid Description
| Source: |
The roots of Polygala tenuifolia Willd. |
| Solvent: |
DMSO, Pyridine, Methanol, Ethanol, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
1.9813 mL |
9.9067 mL |
19.8134 mL |
39.6267 mL |
49.5334 mL |
| 5 mM |
0.3963 mL |
1.9813 mL |
3.9627 mL |
7.9253 mL |
9.9067 mL |
| 10 mM |
0.1981 mL |
0.9907 mL |
1.9813 mL |
3.9627 mL |
4.9533 mL |
| 50 mM |
0.0396 mL |
0.1981 mL |
0.3963 mL |
0.7925 mL |
0.9907 mL |
| 100 mM |
0.0198 mL |
0.0991 mL |
0.1981 mL |
0.3963 mL |
0.4953 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
