Prosapogenin A | CAS:19057-67-1 | Manufacturer ChemFaces

Prosapogenin A

ChemFaces products have been cited in many studies from excellent and top scientific journals

Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC

How to Order

Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com

Delivery time

Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal

Citing Use of our Products

More Impact Factor than five Cite...

* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.

According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $153.1 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

Featured Products

More...

Pinoresinol 4-O-beta-D-glucopyrano...

Catalog No: CFN97180
CAS No: 69251-96-3
Price: $100/20mg

Phyllanthin

Catalog No: CFN99050
CAS No: 10351-88-9
Price: $288/10mg

Quercetin 3-O-glucoside-7-O-rhamno...

Catalog No: CFN90738
CAS No: 18016-58-5
Price: $538/5mg

Dihydrocapsaicin

Catalog No: CFN99918
CAS No: 19408-84-5
Price: $50/20mg

Hederacoside C

Catalog No: CFN90183
CAS No: 14216-03-6
Price: $40/20mg

1,2,3,6-Tetragalloylglucose

Catalog No: CFN00447
CAS No: 79886-50-3
Price: $238/10mg

Picrasidine I

Catalog No: CFN99019
CAS No: 100234-59-1
Price: $368/5mg

Artepillin C

Catalog No: CFN70443
CAS No: 72944-19-5
Price: $ / mg

Cordifolioside A

Catalog No: CFN95040
CAS No: 155179-20-7
Price: $318/10mg

Magnoflorine

Catalog No: CFN98071
CAS No: 2141-09-5
Price: $98/20mg

Description:

Prosapogenin A has anti-obesity, and immunomodulating effects, it exhibits cytotoxic activity against the cancer cell line K562 in vitro.

Targets:

STAT | GLUT

In vitro:

Oncol Lett. 2013 Nov;6(5):1323-1328.

Prosapogenin A induces apoptosis in human cancer cells in vitro via inhibition of the STAT3 signaling pathway and glycolysis.[Pubmed: 24179517]

Signal transducer and activator of transcription 3 (STAT3) is considered to be an oncogene. Blocking STAT3 signaling may induce growth arrest and apoptosis in different types of tumors. Cancer cells utilize the glycolytic pathway to maintain cell growth even when adequate oxygen is present. Glycolysis inhibition is a potential therapeutic modality.
METHODS AND RESULTS:
In the present study, the effects of Prosapogenin A (PSA) from the traditional Chinese medicine, Veratrum, on apoptosis, the STAT3 signaling pathway and glycometabolism in cancer cells were investigated. The results indicated that PSA induced growth inhibition and apoptosis in HeLa, HepG2 and MCF-7 cells. PSA inhibited the STAT3 signaling pathway and modulated the expression of glycometabolism-related genes.
CONCLUSIONS:
The results indicate that the inhibition of the STAT3 signaling and glycometabolism pathways contributes to the PSA-mediated apoptosis of HeLa, HepG2 and MCF-7 cells.

Prosapogenin A Description

Source:	The roots of Ophiopogon japonicus
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Yao Xue Xue Bao. 2013 Sep;48(9):1510-4.

Prosapogenin A inhibits cell growth of MCF7 via downregulating STAT3 and glycometabolism-related gene.[Pubmed: 24358789]

This study is to investigate the inhibitory effect and mechanism of Prosapogenin A (PSA) on MCF7.
METHODS AND RESULTS:
MTT assay was performed to determine the inhibitory effect of PSA on MCF7 cells. PI/Hoechst 33342 double staining was used to detect cell apoptosis. RT-PCR was used to test the mRNA levels of STAT3, GLUT1, HK and PFKL. Western blotting was performed to determine the expression of STAT3 and pSTAT3 protein in MCF7 cells. The results showed that PSA could dose-dependently inhibit cell growth of MCF7 followed by IC50 of 9.65 micrmol x L(-1) and promote cell apoptosis of MCF7. Reduced mRNA levels of STAT3, HK and PFKL were observed in MCF7 cells treated with 5 micromol x L(-1) of PSA. PSA also decreased the level of pSTAT3 protein. STAT3 siRNA caused decrease of mRNA of GLUT1, HK and PFKL which indicated STAT3 could regulate the expressions of GLUT1, HK and PFKL.
CONCLUSIONS:
The results suggested that PSA could inhibit cell growth and promote cell apoptosis of MCF7 via inhibition of STAT3 and glycometabolism-related gene.

Product Name	Prosapogenin A
Price:	$238 / 10mg
CAS No.:	19057-67-1
Catalog No.:	CFN90440
Molecular Formula:	C₃₉H₆₂O₁₂
Molecular Weight:	722.9 g/mol
Purity:	>=98%
Type of Compound:	Steroids
Physical Desc.:	Powder
Source:	The roots of Ophiopogon japonicus
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Anti-inflammatory Compound Library Anticoagulants Compound Library Steroids Compound Library STAT Inhibitor Library GLUT Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.3833 mL	6.9166 mL	13.8332 mL	27.6663 mL	34.5829 mL
5 mM	0.2767 mL	1.3833 mL	2.7666 mL	5.5333 mL	6.9166 mL
10 mM	0.1383 mL	0.6917 mL	1.3833 mL	2.7666 mL	3.4583 mL
50 mM	0.0277 mL	0.1383 mL	0.2767 mL	0.5533 mL	0.6917 mL
100 mM	0.0138 mL	0.0692 mL	0.1383 mL	0.2767 mL	0.3458 mL

CFN99760	Diosgenin glucoside	14144-06-0	576.76	C₃₃H₅₂O₈
CFN90917	Timosaponin AI	68422-00-4	578.78	C₃₃H₅₄O₈
CFN98151	Timosaponin A3	41059-79-4	740.92	C₃₉H₆₄O₁₃
CFN91132	Anemarrhenasaponin III	163047-23-2	756.9	C₃₉H₆₄O₁₄
CFN90440	Prosapogenin A	19057-67-1	722.9	C₃₉H₆₂O₁₂
CFN90445	Polyphyllin C	76296-71-4	722.9	C₃₉H₆₂O₁₂