ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
Citing Use of our Products
How to Order
Orders via your E-mail:
1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Sent to Email: email@example.com
Order & Inquiry & Tech Support
Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
Delivery & Payment method
1. Usually delivery time: Next day delivery by 9:00 a.m. Order now
2. We accept: Wire transfer & Credit card & Paypal & Western Union
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $25.1 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Faculty of Chem. & Nat. Resource ...2014...Acta Physiologiae Plantarum...2015...Sci Rep. 2017, 12953(7)Semyung University2017, 149407J.Acta Agriculturae Scandinavica...2017...Cytotechnology.2017, 69(5):765-773Nutrients.2018, 10(12)Analytical Methods2018, 10(27)
Nat Prod Commun.2018, 10.1177Phytochemistry2018, 15:83-92Molecules.2018, 23(9):E2121Phytomedicine.2018, 38:12-23Molecules.2019, 24(11):E2044Molecules.2019, 24(12):E2286J Mol Histol.2019, 50(4):343-354Phytomedicine.2019, 57:95-104
Saudi Pharm J2020, 10.1016Industrial Crops and Products...2020...Food Funct.2020, 11(2):1322-1333.Front Pharmacol.2020, 11:566490.Food Res Int.2020, 133:109130.The Korea Journal of Herbology...2020...J Sep Sci.2020, 43(22):4148-4161.
Our products had been exported to the following research institutions and universities, And still growing.
Massachusetts General Hospital (USA)Kyushu University (Japan)University of Fribourg (Switzerland)Wroclaw Medical University (Poland)
National Cancer Center Research... (Japan)Macau University of Science and... (China)Lund University (Sweden)Heinrich-Heine-University Düss... (Germany)
University of Zurich (Switzerland)University of Maryland (USA)University of South Australia (Australia)
Inquire / Order:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Food Chem.2019, 278:683-691Chem Biol Interact.2016, 260:168-175Chem Biol Interact.2020, 328:109200.Molecules.2019, 24(24),4583J Nat Med.2020, 74(3):550-560.J Biosci.2020, 45:46.Korean Journal of Pharmacognosy2019, 50(4):285-290Chinese Medicine2019, 14(1)Sci Rep.2019, 9(1):4342Cell Rep.2020, 32(11):108158.
Related Screening Libraries
|| S-Adenosyl-L-methionine, L-methionine, and N-acetylcysteine exert various degrees of protection toward ethanol-induced cell injury, which are related to the efficiency of these compounds in maintaining a high glutathione pool.|
||Sodium Channel | ATPase | Potassium Channel|
|Toxicol Appl Pharmacol. 1989 Feb;97(2):216-29. |
|Inhibition by ethanol of rat liver plasma membrane (Na+,K+)ATPase: protective effect of S-adenosyl-L-methionine, L-methionine, and N-acetylcysteine.[Pubmed: 2538005]|
METHODS AND RESULTS:
S-adenosyl-L-methionine(S-Adenosyl-L-Methtonine,SAM), L-methionine, and N-acetylcysteine (NAC), given to rats during ethanol treatment, prevented the decrease in (Na+,K+)ATPase activity and GSH content. They also reduced steatosis and liver necrosis. The efficiency of these compounds decreased in this order: SAM, methionine, NAC. SAM accelerated the recovery of all parameters studied after ethanol withdrawal, and also protected (Na+,K+)ATPase activity and GSH content of isolated hepatocytes from the deleterious effect of ethanol. These SAM effects were prevented by 1-chloro-2,4-dinitro-benzene, a compound which depletes cell GSH. Treatment of isolated hepatocytes with [35S]SAM led to the synthesis of labeled GSH. The total amount and specific activity of labeled GSH underwent a significant increase, in the presence of 2 mM ethanol or 0.5 mM ACA, which indicates a marked stimulation of GSH synthesis by ethanol and ACA.
These data indicate that ethanol intoxication may inhibit (Na+,K+)ATPase activity; an effect that does not seem to depend on cell necrosis. SAM, methionine, and NAC exert various degrees of protection toward ethanol-induced cell injury, which are related to the efficiency of these compounds in maintaining a high GSH pool.
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.