Science | Nature | Cell | View More
Natural Products
Scoulerine
Scoulerine
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Scoulerine
Price:
CAS No.: 6451-73-6
Catalog No.: CFN96330
Molecular Formula: C19H21NO4
Molecular Weight: 327.4 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The herbs of Corydalis dubia.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • University of Madras (India)
  • Regional Crop Research Institute (Korea)
  • Universidade Católica Portuguesa (Portugal)
  • Helmholtz Zentrum München (Germany)
  • University of Parma (Italy)
  • The Australian National University (Australia)
  • Universidade de Franca (Brazil)
  • Massachusetts General Hospital (USA)
  • Julius Kühn-Institut (Germany)
  • Washington State University (USA)
  • Leibniz Institute of Plant Bioc... (Germany)
  • More...
Package
Featured Products
4-Hydroxybenzyl alcohol

Catalog No: CFN97071
CAS No: 623-05-2
Price: $30/20mg
Ginsenoside Ra2

Catalog No: CFN93293
CAS No: 83459-42-1
Price: $218/5mg
Phillyrin

Catalog No: CFN99998
CAS No: 487-41-2
Price: $30/20mg
Trachelogenin

Catalog No: CFN90598
CAS No: 34209-69-3
Price: $318/10mg
Allicin

Catalog No: CFN90201
CAS No: 539-86-6
Price: $50/20mg
Isosteviol

Catalog No: CFN90544
CAS No: 27975-19-5
Price: $40/20mg
Polyphyllin D

Catalog No: CFN90255
CAS No: 50773-41-6
Price: $118/20mg
Dehydromiltirone

Catalog No: CFN98532
CAS No: 116064-77-8
Price: $438/5mg
Saponin

Catalog No: CFN70204
CAS No: 8047-15-2
Price: $30/20mg
Oxymatrine

Catalog No: CFN99805
CAS No: 16837-52-8
Price: $40/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Scoulerine shows significant cytotoxic effects against both two cancer cell lines (Caco-2 and Hep-G2 cancer cells), with IC50 values 6.44 ± 0.87 and 4.57 ± 0.42, respectively. It shows antiplasmodial activity with IC(50) values of 5.4uM and 3.1uM against the antifolate sensitive and the multidrug resistant P. falciparum strains: TM4/8.2 and K1CB1, respectively.
Targets: Antifection
In vitro:
Nat Prod Commun. 2016 Jun;11(6):753-6.
Cytotoxicity of Naturally Occurring Isoquinoline Alkaloids of Different Structural Types.[Pubmed: 27534109]

METHODS AND RESULTS:
Forty-six isoquinoline alkaloids, of eleven structural types isolated in our laboratory, have been evaluated for their cytotoxicity against two cancer cell lines (Caco-2 and Hep-G2 cancer cells), as well as against normal human lung fibroblast cells. Only Scoulerine, aromoline, berbamine and parfumidine showed significant cytotoxic effects, but only Scoulerine was active against both Caco-2 and Hep-G2 cells (IC50 values 6.44 ± 0.87 and 4.57 ± 0.42, respectively). Unfortunately, except for parfumidine, the other active alkaloids were also cytotoxic to the normal human lung fibroblast cells.
J Ethnopharmacol. 2012 Aug 30;143(1):310-3.
Antimalarial alkaloids from a Bhutanese traditional medicinal plant Corydalis dubia.[Pubmed: 22796506]

METHODS AND RESULTS:
Corydalis dubia is used in Bhutanese traditional medicine as a febrifuge and for treating infections in the blood, liver and bile which correlate to the signs and symptoms of malarial and microbial infections.A systematic extraction and isolation protocol yielded one new natural product, dubiamine, and seven known isoquinoline alkaloids, Scoulerine, cheilanthifoline, protopine, capnoidine, bicuculline, corydecumbine and hydrastine.
CONCLUSIONS:
Among the four alkaloids tested, Scoulerine showed the best antiplasmodial activity with IC(50) values of 5.4μM and 3.1μM against the antifolate sensitive and the multidrug resistant P. falciparum strains: TM4/8.2 and K1CB1, respectively. None of the alkaloids tested showed significant antimicrobial or cytotoxicity activities.
Scoulerine Description
Source: The herbs of Corydalis dubia.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Isolappaol A

Catalog No: CFN95224
CAS No: 131400-96-9
Price: $333/10mg
Glucoliquiritin

Catalog No: CFN95011
CAS No: 93446-18-5
Price: $318/10mg
Naringenin 7-O-gentiobioside

Catalog No: CFN95435
CAS No: 104154-33-8
Price: $368/5mg
Henricine

Catalog No: CFN95244
CAS No: 107783-46-0
Price: $413/5mg
Ganoderenic acid K

Catalog No: CFN95469
CAS No: 942950-94-9
Price: $318/10mg
Maculosidin

Catalog No: CFN95126
CAS No: 522-19-0
Price: $413/5mg
Selina-4(15),7(11)-dien-8-one

Catalog No: CFN95078
CAS No: 54707-47-0
Price: $288/10mg
trans-Cinnamoyl beta-D-glucoside

Catalog No: CFN95497
CAS No: 13080-39-2
Price: $/mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.0544 mL 15.2718 mL 30.5437 mL 61.0874 mL 76.3592 mL
5 mM 0.6109 mL 3.0544 mL 6.1087 mL 12.2175 mL 15.2718 mL
10 mM 0.3054 mL 1.5272 mL 3.0544 mL 6.1087 mL 7.6359 mL
50 mM 0.0611 mL 0.3054 mL 0.6109 mL 1.2217 mL 1.5272 mL
100 mM 0.0305 mL 0.1527 mL 0.3054 mL 0.6109 mL 0.7636 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
4-Hydroxybenzyl alcohol

Catalog No: CFN97071
CAS No: 623-05-2
Price: $30/20mg
Ginsenoside Ra2

Catalog No: CFN93293
CAS No: 83459-42-1
Price: $218/5mg
Phillyrin

Catalog No: CFN99998
CAS No: 487-41-2
Price: $30/20mg
Trachelogenin

Catalog No: CFN90598
CAS No: 34209-69-3
Price: $318/10mg
Allicin

Catalog No: CFN90201
CAS No: 539-86-6
Price: $50/20mg
Isosteviol

Catalog No: CFN90544
CAS No: 27975-19-5
Price: $40/20mg
Polyphyllin D

Catalog No: CFN90255
CAS No: 50773-41-6
Price: $118/20mg
Dehydromiltirone

Catalog No: CFN98532
CAS No: 116064-77-8
Price: $438/5mg
Saponin

Catalog No: CFN70204
CAS No: 8047-15-2
Price: $30/20mg
Oxymatrine

Catalog No: CFN99805
CAS No: 16837-52-8
Price: $40/20mg
Tags: buy Scoulerine | Scoulerine supplier | purchase Scoulerine | Scoulerine cost | Scoulerine manufacturer | order Scoulerine | Scoulerine distributor