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|Size /Price /Stock
||10 mM * 1 mL in DMSO / $423.2 / In-stock||Other Packaging
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More articles cited ChemFaces products.
Sci. Rep.2015, 14-23China Pharmacy2015, 26(27)Ind Crops Prod.2015, 67:185-191Am J Chin Med.2016, 44(6):1255-1271Planta Med.2016, 82(13):1208-16Sci Rep. 2017, 12953(7)J Ethnopharmacol.2017, 206:73-77FEMS Microbiol Lett.2017, 364(11)
Front Pharmacol.2017, 8:205Nutrients.2018, 10(12):E1998Asian J of Pharmaceutical&Clinica...2018...Cell Death Dis.2019, 10(12):882Nutrients.2019, 11(4):E936Nutrients.2019, 12(1):E40Food Res Int.2019, 123:125-134J Ethnopharmacol.2019, 244:112074
Phytomedicine.2019, 61:152813J Nat Prod.2019, 82(4):1002-1008Saudi Pharm J2020, 10.1016Plant Cell Tiss Org2020, 1-16Drug Des Devel Ther.2020, 14:5189-5204.Biomol Ther (Seoul)....2020...Evid Based Complement Alternat Me...2021...
Our products had been exported to the following research institutions and universities, And still growing.
Institute of Pathophysiology Me... (Austria)Mahidol University (Thailand)University of Ioannina (Greece)Uniwersytet Jagielloński w Kra... (Poland)
University of Wollongong (Australia)Universidade do Porto (Portugal)Shanghai Institute of Organic C... (China)Instytut Nawozów Sztucznych w ... (Poland)
Aveiro University (Portugal)Julius Kühn-Institut (Germany)Funda??o Universitária de Dese... (Brazil)
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Nat Prod Sci.2016, 22(2)Food and Agriculture Org. Of the UN2019, 151-160Oncotarget.2017, 9(3):4161-4172Malaysian J of Fundamental and Applied Sciences 2018, 14(3):368-373Med Sci Monit.2019, 25:9499-9508Korean J Dent Mater2020, 47(2):63-70.BMB Rep.2020, 53(4):218-222.Molecules.2018, 23(7):E1817Evid Based Complement Alternat Med.2016, 2016:1230294Chem Biol Interact.2018, 290:44-51
Related Screening Libraries
||Sotetsuflavone is a potent inhibitor of DENV-NS5 RdRp (Dengue virus NS5 RNA-dependent RNA polymerase) with an IC50 of 0.16 uM, is the most active compound of this series.|
|Planta Med. 2013 Sep;79(14):1313-8. |
|Structure-activity relationship study of biflavonoids on the Dengue virus polymerase DENV-NS5 RdRp.[Pubmed: 23929244 ]|
|Dengue virus is the world's most prevalent human pathogenic arbovirus. There is currently no treatment or vaccine, and solutions are urgently needed. We previously demonstrated that biflavonoids from Dacrydium balansae, an endemic gymnosperm from New Caledonia, are potent inhibitors of the Dengue virus NS5 RNA-dependent RNA polymerase.
METHODS AND RESULTS:
Herein we describe the structure-activity relationship study of 23 compounds: biflavonoids from D. balansae (1-4) and from D. araucarioides (5-10), hexamethyl-amentoflavone (11), cupressuflavone (12), and apigenin derivatives (13-23). We conclude that 1) over the four different biflavonoid skeletons tested, amentoflavone (1) and robustaflavone (5) are the most promising ones for antidengue drug development, 2) the number and position of methyl groups on the biflavonoid moiety modulate their inhibition of Dengue virus NS5 RNA-dependent RNA polymerase, and 3) the degree of oxygenation of flavonoid monomers influences their antidengue potential.
Sotetsuflavone (8), with an IC50 = 0.16 μM, is the most active compound of this series and is the strongest inhibitor of the Dengue virus NS5 RNA-dependent RNA polymerase described in the literature.
||The herbs of Selaginella tamariscina
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|J Nat Prod. 2003 Jul;66(7):1002-5. |
|Chemical constituents from Amentotaxus yunnanensis and Torreyayunnanensis.[Pubmed: 12880325 ]|
|In a chemical study of taxonomically related Taxaceae plants of Yunnan Province, China, seven compounds, including a new amentoflavone biflavonoid, 2,3-dihydro-7,7' '-dimethoxyamentoflavone (1), were isolated from Amentotaxus yunnanensis, and 12 isolates were obtained from Torreya yunnanensis. From the latter plant, a new abietane diterpene, torreyayunnin (7), is reported for the first time.
METHODS AND RESULTS:
The known isolates from A. yunnanensis have been identified as sequoiaflavone (3), Sotetsuflavone (4), 7,7' '-dimethoxyamentoflavone (5), lutein, beta-sitosterol, and sequoyitol. Amentoflavone (2), Sotetsuflavone (4), sciadopitysin (6), 12-hydroxydehydroabietinol, meridinol, balanophonin, (+)-pinoresinol monomethyl ether, (+)-pinoresinol monomethyl ether glucoside, erythro-1-(4-hydroxy-3-methoxyphenyl)-2-[4-[2-formyl-(E)-vinyl]-2- methoxyphenoxy]propane-1,3-diol, threo-1-(4-hydroxy-3-methoxyphenyl)-2- [4-[2-formyl-(E)-vinyl]-2-methoxyphenoxy] propane-1,3-diol, and (E)-2-butenedioic acid were identified as known isolates from T. yunnanensis.
The presence of the amentoflavone biflavonoids (1, 3-5) in A. yunnanensis supports its placement in the Taxaceae. The occurrence of the biflavonoid Sotetsuflavone (4) in both A. yunnanensis and T. yunnanensis suggests that these two genera are closely related. The identification and structural elucidation of these isolates were based on spectral data analysis including 1D and 2D NMR.