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Spiradine F
Spiradine F
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Spiradine F
Price:
CAS No.: 21040-64-2
Catalog No.: CFN98058
Molecular Formula: C24H33NO4
Molecular Weight: 399.5 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The herbs of Spiraea salicifolia L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Spiradine F can significantly inhibit platelet-activating factor(PAF)-induced platelet aggregation in a concentration-dependent manner.
Targets: PAFR
In vitro:
European Journal of Pharmacology.2002 Aug;449(1-2):23–28.
Antiplatelet aggregation activity of diterpene alkaloids from Spiraea japonica.[Reference: WebLink]

METHODS AND RESULTS:
Six diterpene alkaloids with an atisine-type C20-skeleton isolated from the Chinese herbal medicines Spiraea japonica var. acuta and S.japonica var. ovalifolia, as well as eight derivatives of spiramine C and Spiradine F were evaluated for the ability to inhibit aggregation of rabbit platelets induced by arachidonic acid, ADP, and platelet-activating factor (PAF) in vitro.
Spiradine F Description
Source: The herbs of Spiraea salicifolia L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.5031 mL 12.5156 mL 25.0313 mL 50.0626 mL 62.5782 mL
5 mM 0.5006 mL 2.5031 mL 5.0063 mL 10.0125 mL 12.5156 mL
10 mM 0.2503 mL 1.2516 mL 2.5031 mL 5.0063 mL 6.2578 mL
50 mM 0.0501 mL 0.2503 mL 0.5006 mL 1.0013 mL 1.2516 mL
100 mM 0.025 mL 0.1252 mL 0.2503 mL 0.5006 mL 0.6258 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
CFN906603-Deoxyaconitine3175-95-9629.74C34H47NO10
CFN99915Aconitine302-27-2645.75C34H47NO11
CFN9066312-Epinapelline110064-71-6359.5C22H33NO3
CFN90393Napellonine509-24-0357.49C22H31NO3
CFN96214Songoramine23179-78-4355.5C22H29NO3
CFN98058Spiradine F21040-64-2399.5 C24H33NO4
CFN99243Spiramine A114531-28-1399.5 C24H33NO4
CFN90228Bullatine A1354-84-3343.51C22H33NO2
CFN93074Karacoline39089-30-0377.52C22H35NO4
CFN91495Guan-fu base A1394-48-5429.5C24H31NO6
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