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    Natural Products
    Sulochrin
    Sulochrin
    Information
    CAS No. 519-57-3 Price
    Catalog No.CFN96651Purity>=98%
    Molecular Weight332.30Type of CompoundPhenols
    FormulaC17H16O7Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)  (SDF)
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    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
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    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
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  • Package
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    Sulochrin

    Sulochrin
    Product Name Sulochrin
    CAS No.: 519-57-3
    Catalog No.: CFN96651
    Molecular Formula: C17H16O7
    Molecular Weight: 332.30 g/mol
    Purity: >=98%
    Type of Compound: Phenols
    Physical Desc.: Powder
    Targets: HCV | Antifection
    Source: The culture broth of an Aspergillus species.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price:
    Inquire / Order: manager@chemfaces.com
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  • Molecules.2019, 24(24):E4536
  • Natural Product Communications2020, doi: 10.1177.
  • Universidade Estadual Paulista2017, 42785
  • The Pharmaceutical Society of Japan2018, 138(4):571-579
  • ARPN Journal of Eng.& Applied Sci.2016, 2199-2204
  • J Sci Food Agric.2018, 98(3):1153-1161
  • Sci Rep.2019, 9:12132
  • Curr Top Med Chem.2020, 20(21):1898-1909.
  • Fitoterapia.2018, 124:92-102
  • Antioxidants (Basel).2020, 9(4):284.
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Antibacterial Compound Library
  • Antiviral Compound Library
  • Antifungal Compound Library
  • Phenols Compound Library
  • HCV Inhibitor Library
  • Antifection Inhibitor Library
  • Biological Activity
    Description: Sulochrin shows antifungal and antibacterial activities, it can inhibit hepatitis C virus (HCV) infection in a dose-dependent manner without any apparent cytotoxicity up to 50 uM. Sulochrin has an inhibitory activity to eosinophil degranulation.
    Targets: HCV | Antifection
    In vitro:
    Biochem Biophys Res Commun. 2013 Nov 1;440(4):515-20.
    Specific inhibition of hepatitis C virus entry into host hepatocytes by fungi-derived sulochrin and its derivatives.[Pubmed: 24099774 ]
    Hepatitis C virus (HCV) is a major causative agent of hepatocellular carcinoma. Although various classes of anti-HCV agents have been under clinical development, most of these agents target RNA replication in the HCV life cycle.
    METHODS AND RESULTS:
    To achieve a more effective multidrug treatment, the development of new, less expensive anti-HCV agents that target a different step in the HCV life cycle is needed. We prepared an in-house natural product library consisting of compounds derived from fungal strains isolated from seaweeds, mosses, and other plants. A cell-based functional screening of the library identified Sulochrin as a compound that decreased HCV infectivity in a multi-round HCV infection assay. Sulochrin inhibited HCV infection in a dose-dependent manner without any apparent cytotoxicity up to 50 μM. HCV pseudoparticle and trans-complemented particle assays suggested that this compound inhibited the entry step in the HCV life cycle.
    CONCLUSIONS:
    Sulochrin showed anti-HCV activities to multiple HCV genotypes 1a, 1b, and 2a. Co-treatment of Sulochrin with interferon or a protease inhibitor telaprevir synergistically augmented their anti-HCV effects.
    Chem Pharm Bull (Tokyo). 1983 Dec;31(12):4543-8.
    Studies on metabolites produced by Aspergillus terreus var. aureus. I. Chemical structures and antimicrobial activities of metabolites isolated from culture broth[Reference: WebLink]
    A fungus which was identified as Aspergillus terreus var. aureus showed antifungal and antibacterial activities.
    METHODS AND RESULTS:
    Through the investigation of its metabolites, six compounds (1-6) were isolated; emodin (1), dihydrogeodin (2), questin (3), Sulochrin (5), the new metabolite 2-(3-chloro-4-methyl-γ-resorcyloyl)-5-hydroxy-m-anisic acid methyl ester (4), which is a monochloro derivative of Sulochrin (5), and compound (6), the chemical structure of which has not yet been clarified.
    CONCLUSIONS:
    Dihydrogeodin (2), Sulochrin (5), 4 and 6 showed antifungal and antibacterial activities, and 6 has especially strong antifungal activity towards Trichophyton mentagrophytes.
    Sulochrin Description
    Source: The culture broth of an Aspergillus species.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.0093 mL 15.0466 mL 30.0933 mL 60.1866 mL 75.2332 mL
    5 mM 0.6019 mL 3.0093 mL 6.0187 mL 12.0373 mL 15.0466 mL
    10 mM 0.3009 mL 1.5047 mL 3.0093 mL 6.0187 mL 7.5233 mL
    50 mM 0.0602 mL 0.3009 mL 0.6019 mL 1.2037 mL 1.5047 mL
    100 mM 0.0301 mL 0.1505 mL 0.3009 mL 0.6019 mL 0.7523 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Bioorg Med Chem Lett. 1999 Jul 19;9(14):1945-8.
    Effects of ortho-substituent groups of sulochrin on inhibitory activity to eosinophil degranulation.[Pubmed: 10450959]
    Sulochrin, a metabolite of fungi, has been shown to have an inhibitory activity to eosinophil degranulation.
    METHODS AND RESULTS:
    A series of Sulochrin derivatives substituted at ortho-positions to the 10-carbonyl group was examined the activity. The importance of alkylester at C-6 position and several chemical properties of substituted groups at ortho-positions to exhibit activity are described.
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