Taxinine M | CAS:135730-55-1 | Manufacturer ChemFaces

Taxinine M

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Description:

Taxinine M is a natural product from Chinese yew Taxus chinensis.

In vitro:

J Pharm Biomed Anal. 2015 Mar 25;107:346-54.

Simultaneous determination of seven taxoids in rat plasma by UPLC-MS/MS and pharmacokinetic study after oral administration of Taxus yunnanensis extracts.[Pubmed: 25645339]

METHODS AND RESULTS:
A rapid, sensitive and reliable method has been developed and validated for the simultaneous determination of seven taxoids including 10-deacetylbaccatin III (10-DAB III), baccatin III, 5-epi-canadensene, Taxinine M, 10-deacetyltaxol (10-DAT), cephalomannine and paclitaxel in rat plasma using docetaxel as the internal standard (IS). The plasma samples were pretreated by liquid-liquid extraction with methyl tert-butyl ether. The chromatographic separation was achieved on a C18 column (50 mm × 2.1 mm, 1.8 μm, Waters, USA) with a gradient elution program consisting of methanol and water (containing 0.1% formic acid) at a flow rate of 0.2 mL/min. Detection was performed under the selected reaction monitoring (SRM) scan using an electrospray ionization (ESI) in the positive ion mode. The mass transitions were as follows: m/z 567.4→444.9 for 10-DAB III, m/z 609.0→549.3 for baccatin III, m/z 617.4→496.9 for 5-epi-canadensene, m/z 709.6→649.3 for Taxinine M, m/z 834.8→307.9 for 10-DAT, m/z 854.5→285.4 for cephalomannine, m/z 876.8→307.3 for paclitaxel and m/z 830.8→549.6 for IS, respectively. All calibration curves exhibited good linearity (r(2)>0.99) over a wide concentration range for all components. The intra-day and inter-day precisions at three different levels were both less than 14.3% in terms of relative standard deviation (RSD) and the accuracies ranged from -8.3% to 14.8% in terms of relative error (RE). The extraction recoveries of the seven compounds ranged from 62.5% to 100.5%.
CONCLUSIONS:
The developed method was successfully applied to the pharmacokinetic study of the seven taxoids in rat plasma after oral administration of the crude extract of the twigs and leaves of Taxus yunnanensis.

Taxinine M Description

Source:	The seeds of Chinese yew Taxus chinensis.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

CAS No.	135730-55-1	Price
Catalog No.	CFN96634	Purity	>=98%
Molecular Weight	686.70	Type of Compound	Diterpenoids
Formula	C₃₅H₄₂O₁₄	Physical Description	Powder
Download	COA MSDS	Similar structural	Comparison (Web) (SDF)

Product Name	Taxinine M
CAS No.:	135730-55-1
Catalog No.:	CFN96634
Molecular Formula:	C₃₅H₄₂O₁₄
Molecular Weight:	686.70 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The seeds of Chinese yew Taxus chinensis.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Diterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.4562 mL	7.2812 mL	14.5624 mL	29.1248 mL	36.406 mL
5 mM	0.2912 mL	1.4562 mL	2.9125 mL	5.825 mL	7.2812 mL
10 mM	0.1456 mL	0.7281 mL	1.4562 mL	2.9125 mL	3.6406 mL
50 mM	0.0291 mL	0.1456 mL	0.2912 mL	0.5825 mL	0.7281 mL
100 mM	0.0146 mL	0.0728 mL	0.1456 mL	0.2912 mL	0.3641 mL

CFN96905	Decinnamoyltaxinine J	84652-33-5	578.65	C₃₀H₄₂O₁₁
CFN99887	2-Deacetoxytaxinine B	191547-12-3	606.7	C₃₅H₄₂O₉
CFN99855	Taxinine B	18457-44-8	664.8	C₃₇H₄₄O₁₁
CFN96914	7beta-Acetoxytaxuspine C	256347-91-8	664.74	C₃₇H₄₄O₁₁
CFN96639	Taxezopidine G	205440-22-8	608.72	C₃₅H₄₄O₉
CFN89400	7-Deacetoxytaxinine J	18457-45-9	650.75	C₃₇H₄₆O₁₀
CFN95562	Taxezopidine H	205440-23-9	608.7	C₃₅H₄₄O₉
CFN96989	2-Deacetoxytaxinine J	119347-14-7	650.76	C₃₇H₄₆O₁₀
CFN96979	2,7-Dideacetoxytaxinine J	115810-14-5	592.72	C₃₅H₄₄O₈
CFN96923	9-Deacetyltaxinine E	284672-78-2	608.72	C₃₅H₄₄O₉