Taxiresinol | CAS:40951-69-7 | Manufacturer ChemFaces

Taxiresinol

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Description:

Taxiresinol shows anticancer, antinociceptive, and antiallergic activities, it shows inhibitory activity on induced histamine release from the human basophilic cell line, KU812. Taxiresinol can protect the hepatocytes from apoptosis via an inhibition of TNF- alpha production by activated macrophages and a direct inhibition of apoptosis induced by TNF- alpha in D-GalN/LPS-treated mice.

Targets:

TNF-α | Immunology & Inflammation related

In vitro:

Bioorg Med Chem. 2003 Nov 17;11(23):4945-8.

Absolute configuration and anticancer activity of taxiresinol and related lignans of Taxus wallichiana.[Pubmed: 14604656]

METHODS AND RESULTS:
Absolute configuration of Taxiresinol 1, a lignan from the heartwood of Taxus wallichiana has been determined as 8R, 8'R, and 7'R with the help of chemical correlation method and X-ray crystallography. The anticancer activity of Taxiresinol 1 and other two lignans 2, 3 were also studied.
CONCLUSIONS:
Taxiresinol 1 showed notable anticancer activity in the in vitro bioassays against colon, liver, ovarian and breast cancer cell lines.

Biol Pharm Bull. 2006 Nov;29(11):2310-2.

Antiallergic activity of aqueous extracts and constituents of Taxus yunnanensis.[Pubmed: 17077536]

The H2O, H2O/MeOH (1:1) extracts from the wood of Taxus yunnanensis showed a remarkable inhibitory effect on induced histamine release from the human basophilic cell line, KU812.
METHODS AND RESULTS:
The eleven constituents purified from the wood extracts of Taxus yunnanensis were tested by an in vitro histamine release inhibition assay. Among them, secoisolarciresinol and Taxiresinol were found to show inhibitory activities.
CONCLUSIONS:
A new neolignan, 2-[2-hydroxy-5-(3-hydroxypropyl)-3-methoxyphenyl]-1-(4-hydroxy-3-methoxyphenyl)propane-1,3-diol, was isolated from the wood of Taxus yunnanensis.

In vivo:

J Ethnopharmacol. 2003 Dec;89(2-3):265-70.

Anti-inflammatory and antinociceptive activity of taxoids and lignans from the heartwood of Taxus baccata L.[Pubmed: 14611890]

METHODS AND RESULTS:
Four taxoids (taxusin, baccatin VI, baccatin III and 1beta-hydroxybaccatin I) and five lignans (lariciresinol, Taxiresinol, 3'-demethylisolariciresinol-9'-hydroxyisopropylether, isolariciresinol and 3-demethylisolariciresinol) were isolated from the heartwood of Taxus baccata L. (Taxaceae) growing in Turkey through chromatographic techniques. In vivo anti-inflammatory and antinociceptive activity of these compounds were investigated.
CONCLUSIONS:
All the compounds were shown to possess significant antinociceptive activity against p-benzoquinone-induced abdominal contractions, while only lignan derivatives significantly inhibited carrageenan-induced hind paw edema in mice.

Taxiresinol Description

Source:	The branches of Taxus wallichiana
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Animal Research:

Planta Med. 2004 Jan;70(1):29-33.

Hepatoprotective effect of taxiresinol and (7'R)-7'-hydroxylariciresinol on D-galactosamine and lipopolysaccharide-induced liver injury in mice.[Pubmed: 14765289]

The hepatoprotective effect of Taxiresinol ( 1) and (7' R)-7'-hydroxylariciresinol ( 2), two tetrahydrofuran-type lignans isolated from the wood of Taxus yunnanensis, were investigated on D-galactosamine ( D-GalN)/lipopolysaccharide (LPS)-induced hepatic liver injury in mice.
METHODS AND RESULTS:
Pre-administration of Taxiresinol or 2 at doses of 50 and 10 mg/kg ( i. p.) at 12 and 1 h before D-GalN/LPS injection significantly inhibited hepatocyte DNA fragmentation and apoptotic body formation. Pre-treatment of these two lignans further suppressed hepatic necrosis which occur at later stage of D-GalN/LPS intoxication as demonstrated by the significant and dose-dependent reduction in serum glutamic pyruvic transaminase (sGPT) and serum glutamic oxaloacetic transaminase (sGOT) at 8 h after intoxication. The elevation of serum tumor necrosis factor-alpha (TNF- alpha) level by D-GalN/LPS toxication was significantly inhibited by Taxiresinol or 2 at doses of 50 and 10 mg/kg. Moreover, both of these lignans significantly protected hepatocytes from D-GalN/TNF- alpha-induced cell death in primary cultured mouse hepatocytes.
CONCLUSIONS:
These results suggested that Taxiresinol and 2 had protected the hepatocytes from apoptosis via an inhibition of TNF- alpha production by activated macrophages and a direct inhibition of apoptosis induced by TNF- alpha in D-GalN/LPS-treated mice.

CAS No.	40951-69-7	Price
Catalog No.	CFN97744	Purity	>=98%
Molecular Weight	346.38	Type of Compound	Lignans
Formula	C₁₉H₂₂O₆	Physical Description	Powder
Download	COA MSDS SDF	Similar structural	Comparison (Web) (SDF)

Product Name	Taxiresinol
CAS No.:	40951-69-7
Catalog No.:	CFN97744
Molecular Formula:	C₁₉H₂₂O₆
Molecular Weight:	346.38 g/mol
Purity:	>=98%
Type of Compound:	Lignans
Physical Desc.:	Powder
Targets:	TNF-伪 \| Immunology & Inflammation related
Source:	The branches of Taxus wallichiana
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Anti-inflammatory Compound Library Hepatoprotective Compound Library Anti-allergy Compound Library Anti-nociceptive Compound Library Anti-histamine release Compound Library Lignans Compound Library TNF-α Inhibitor Library Immunology & Inflammation related Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.887 mL	14.435 mL	28.87 mL	57.7401 mL	72.1751 mL
5 mM	0.5774 mL	2.887 mL	5.774 mL	11.548 mL	14.435 mL
10 mM	0.2887 mL	1.4435 mL	2.887 mL	5.774 mL	7.2175 mL
50 mM	0.0577 mL	0.2887 mL	0.5774 mL	1.1548 mL	1.4435 mL
100 mM	0.0289 mL	0.1444 mL	0.2887 mL	0.5774 mL	0.7218 mL

CFN95031	9-O-Acetyl-fargesol	449172-61-6	446.5	C₂₄H₃₀O₈
CFN96706	5'-Methoxylariciresinol	105256-12-0	390.43	C₂₁H₂₆O₇
CFN92502	Justiciresinol	136051-41-7	390.4	C₂₁H₂₆O₇
CFN89318	Ciwujiatone	218901-26-9	434.44	C₂₂H₂₆O₉
CFN99265	5,5'-Dimethoxylariciresinol	116498-58-9	420.5	C₂₂H₂₈O₈
CFN99700	9-O-Feruloyl-5,5'-dimethoxylariciresinol	166322-14-1	596.6	C₃₂H₃₆O₁₁
CFN99647	5,5'-Dimethoxylariciresinol 4-O-glucoside	154418-16-3	582.6	C₂₈H₃₈O₁₃
CFN95390	Tortoside B (Manglieside E)	190655-17-5	582.6	C₂₈H₃₈O₁₃
CFN91784	Tortoside A	190655-16-4	580.58	C₂₈H₃₆O₁₃
CFN96282	Sanshodiol	54854-91-0	358.4	C₂₀H₂₂O₆