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    Natural Products
    Theaflavin-3'-gallate
    Information
    CAS No. 28543-07-9 Price $458 / 20mg
    Catalog No.CFN98599Purity>=98%
    Molecular Weight716.6Type of CompoundFlavonoids
    FormulaC36H28O16Physical DescriptionPowder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $256.0 / In-stock
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    Theaflavin-3'-gallate

    Theaflavin-3'-gallate
    Product Name Theaflavin-3'-gallate
    CAS No.: 28543-07-9
    Catalog No.: CFN98599
    Molecular Formula: C36H28O16
    Molecular Weight: 716.6 g/mol
    Purity: >=98%
    Type of Compound: Flavonoids
    Physical Desc.: Powder
    Source: The leaves of Camellia sinensis (L.) O. Kuntze.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Price: $458 / 20mg
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  • Clin Exp Pharmacol Physiol.2020, doi: 10.1111
  • Molecules.2016, 21(10)
  • J Sci Food Agric.2017, 97(5):1656-1662
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    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
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  • Biological Activity
    Description: Theaflavin-3'-gallate, acts as prooxidants and induces oxidative stress, with carcinoma cells more sensitive than normal fibroblasts.
    In vitro:
    Basic Clin Pharmacol Toxicol. 2008 Jul;103(1):66-74.
    Theaflavin-3-gallate and theaflavin-3'-gallate, polyphenols in black tea with prooxidant properties.[Pubmed: 18346048]
    This study compared the in vitro responses of human gingival fibroblasts and of carcinoma cells derived from the tongue to theaflavin-3-gallate (TF-2A) and Theaflavin-3'-gallate (TF-2B), polyphenols in black tea.
    METHODS AND RESULTS:
    In a cell-free assay, TF-2A and Theaflavin-3'-gallate reacted directly with reduced glutathione (GSH), in a time- and concentration-dependent manner. Intracellular storages of GSH were depleted on treatment of the cells with the theaflavin monomers. Depletion of intracellular GSH was more extensive with TF-2A than with Theaflavin-3'-gallate and was more pronounced in the carcinoma, than in the normal, cells. The toxicities of the theaflavins were potentiated when the cells were cotreated with the GSH depleter, d,l-buthionine-[S,R]-sulfoximine. In the presence of catalase, pyruvate and divalent cobalt, all scavengers of reactive oxygen species, the cytotoxicities of the theaflavins were lessened. TF-2A and Theaflavin-3'-gallate induced lipid peroxidation in the carcinoma cells, whereas in the fibroblasts, peroxidation was evident upon exposure to TF-2A, but not to Theaflavin-3'-gallate.
    CONCLUSIONS:
    These studies demonstrated that the black tea theaflavin monomers, TF-2A and Theaflavin-3'-gallate, act as prooxidants and induce oxidative stress, with carcinoma cells more sensitive than normal fibroblasts.
    Theaflavin-3'-gallate Description
    Source: The leaves of Camellia sinensis (L.) O. Kuntze.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.3955 mL 6.9774 mL 13.9548 mL 27.9096 mL 34.887 mL
    5 mM 0.2791 mL 1.3955 mL 2.791 mL 5.5819 mL 6.9774 mL
    10 mM 0.1395 mL 0.6977 mL 1.3955 mL 2.791 mL 3.4887 mL
    50 mM 0.0279 mL 0.1395 mL 0.2791 mL 0.5582 mL 0.6977 mL
    100 mM 0.014 mL 0.0698 mL 0.1395 mL 0.2791 mL 0.3489 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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