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    Natural Products
    Viscumneoside III
    Information
    CAS No. 118985-27-6 Price $288 / 10mg
    Catalog No.CFN89421Purity>=98%
    Molecular Weight596.53Type of CompoundFlavonoids
    FormulaC27H32O15Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $207.4 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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    Viscumneoside III

    Viscumneoside III
    Product Name Viscumneoside III
    CAS No.: 118985-27-6
    Catalog No.: CFN89421
    Molecular Formula: C27H32O15
    Molecular Weight: 596.53 g/mol
    Purity: >=98%
    Type of Compound: Flavonoids
    Physical Desc.: Powder
    Targets: Tyrosinase
    Source: The herbs of Taxillus sutchuenensis
    Solvent: DMSO, Methanol, Ethanol, etc.
    Price: $288 / 10mg
    Inquire / Order: manager@chemfaces.com
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
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  • Biological Activity
    Description: Viscumneoside III demonstrates high tyrosinase inhibition, it can be utilized in skin whitening cosmetics.
    Targets: Tyrosinase
    In vitro:
    Chem Biodivers. 2011 Sep;8(9):1682-8.
    Flavanone glycosides from viscum coloratum and their inhibitory effects on osteoclast formation.[Pubmed: 21922656 ]
    Two novel flavanone glycosides, homoeriodictyol 7-O-β-D-[6-(3-hydroxybutanoyl)glucopyranoside] (viscumneoside IX; 1) and homoeriodictyol 7-O-β-D-[6-(3-hydroxybutanoyl)glucopyranosyl](1→2)-β-D-glucopyranoside (viscumneoside X; 2), together with four known flavanoids, 2-homoeriodictyol 7-O-β-D-glucopyranoside (3), viscumneoside I (4), Viscumneoside III (5), and 4',5-dihydroxy-3'-methoxy-7-(2-O-α-L-rhamnopyranosyl-β-D-glucopyranosyloxy)flavanone (6) were isolated from stems and leaves of Viscum coloratum.
    METHODS AND RESULTS:
    Their structures were elucidated on the basis of their NMR spectra, HR-FAB-MS data, and acid hydrolysis. Inhibitory effects of the four compounds 1-4 on the formation of osteoclast-like multinucleated cells were investigated. As a result, all the four flavanoids showed significant inhibitory effects on the formation of osteoclast-like multinuclear cells even at a low concentration of 2 μg/ml. The activities of 1-4 at such a concentration exceeded or approximated to that of elcitonin, the positive control drug at a concentration of 2 U/ml, suggesting that they may be of interest for the development of new anti-osteoporosis drugs.
    Viscumneoside III Description
    Source: The herbs of Taxillus sutchuenensis
    Solvent: DMSO, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6764 mL 8.3818 mL 16.7636 mL 33.5272 mL 41.909 mL
    5 mM 0.3353 mL 1.6764 mL 3.3527 mL 6.7054 mL 8.3818 mL
    10 mM 0.1676 mL 0.8382 mL 1.6764 mL 3.3527 mL 4.1909 mL
    50 mM 0.0335 mL 0.1676 mL 0.3353 mL 0.6705 mL 0.8382 mL
    100 mM 0.0168 mL 0.0838 mL 0.1676 mL 0.3353 mL 0.4191 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Kinase Assay:
    Korean Journal of Plant Resources, 2016,29(6):690-698.
    In vitro Anti-Tyrosinase Activity of Viscumneoside III and Homoflavoyadorinin B Isolated from Korean Mistletoe (Viscum album)[Reference: WebLink]

    METHODS AND RESULTS:
    Various bioactive substances are found in mistletoe, including Viscumneoside III (1) and homoflavoyadorinin B (2), both which inhibit tyrosinase. These two compounds are mainly found in the EtOAc fraction of the mistletoe extract and demonstrate higher rates of tyrosinase inhibition than ascorbic acid, which was used as a control.
    CONCLUSIONS:
    Our results suggest that mistletoe extracts can be utilized in skin whitening cosmetics.
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