Vitexin 7-glucoside | CAS:35109-95-6 | Manufacturer ChemFaces

Vitexin 7-glucoside

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Vitexin-7-glucoside exhibits high intestinal permeability, and predictive of excellent human absorption, which awaits confirmation from further investigation in vivo.

In vitro:

European Journal of Medicinal Chemistry, 2006, 41(5):605-610.

Prediciton of human absorption of natural compounds by the non-everted rat intestinal model.[Reference: WebLink]

A major concern in natural drug research is that many substances with potent biological activity in vitro are unable to generate good activity in vivo owing to their poor water-solubility, poor permeability and/or poor stability. The permeability of drug candidates across the intestinal mucosa is one of the most important factors in defining drug bioavailability and biological activity. In order to screen promising compounds for further investigation, a non-everted rat intestinal sac model has been developed successfully to assay the permeability of natural compounds and to predict their human absorption.
METHODS AND RESULTS:
In this system, the drug solution was placed in non-everted intestinal sacs (NEIS), which were placed in an acceptor solution and the permeability of drug across intestine walls was determined. The feasibility of this method has been validated and demonstrated for 11 model compounds chosen from currently marketed drugs whose human fraction absorbed (Fa) data have been reported. The results of the studies indicate that a good relationship exists between the permeability of the model drugs and their corresponding Fa data. The permeability of 13 natural compounds was evaluated using this system. Only fraxinellone and Vitexin 7-glucoside exhibited high intestinal permeability, and predictive of excellent human absorption, which awaits confirmation from further investigation in vivo.
CONCLUSIONS:
This model provides an alternative method to everted intestinal sacs for the evaluation of in vitro permeability in rats, and for estimating human absorption of drugs. It may therefore hold great promise for oral absorption screening of new drug candidates.

Vitexin 7-glucoside Description

Source:	The fruits of Crataegus pinnatifida Bge.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Vitexin 7-glucoside
Price:
CAS No.:	35109-95-6
Catalog No.:	CFN70343
Molecular Formula:	C₂₇H₃₀O₁₅
Molecular Weight:	594.5 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The fruits of Crataegus pinnatifida Bge.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Flavonoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.6821 mL	8.4104 mL	16.8209 mL	33.6417 mL	42.0521 mL
5 mM	0.3364 mL	1.6821 mL	3.3642 mL	6.7283 mL	8.4104 mL
10 mM	0.1682 mL	0.841 mL	1.6821 mL	3.3642 mL	4.2052 mL
50 mM	0.0336 mL	0.1682 mL	0.3364 mL	0.6728 mL	0.841 mL
100 mM	0.0168 mL	0.0841 mL	0.1682 mL	0.3364 mL	0.4205 mL

CFN90943	Isovitexin 2''-O-arabinoside	53382-71-1	564.49	C₂₆H₂₈O₁₄
CFN95314	Isovitexin-2''-O-rhamnoside (2''-O-alpha-L-Rhamnopyranosyl-isovitexin)	72036-50-1	578.5	C₂₇H₃₀O₁₄
CFN95304	Isomargaritene	64271-11-0	592.6	C₂₈H₃₂O₁₄
CFN99341	6''-O-acetylisovitexin	1223097-20-8	474.4	C₂₃H₂₂O₁₁
CFN90132	Meloside A	60767-80-8	594.52	C₂₇H₃₀O₁₅
CFN90133	Isosaponarin	19416-87-6	594.52	C₂₇H₃₀O₁₅
CFN90131	Vaccarin	53452-16-7	726.64	C₃₂H₃₈O₁₉
CFN95296	Isosaponarin 2''-O-glucoside (Isovitexin-2''-4'-di-O-beta-D-glucoside)	63316-27-8	756.7	C₃₃H₄₀O₂₀
CFN95252	Vaccarin E	2252345-81-4	904.8	C₄₂H₄₈O₂₂
CFN90134	Saponarin	20310-89-8	594.52	C₂₇H₃₀O₁₅