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Yadanzioside A
Yadanzioside A
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Yadanzioside A
Price:
CAS No.: 95258-15-4
Catalog No.: CFN96425
Molecular Formula: C32H44O16
Molecular Weight: 684.68 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Source: The seeds of Brucea javanica.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Yadanzioside A has antileukemic activity.
In vitro:
Phytother Res. 2011 Dec;25(12):1796-800.
Seven quassinoids from Fructus Bruceae with cytotoxic effects on pancreatic adenocarcinoma cell lines.[Pubmed: 21480411 ]
Our previous studies showed that the alcohol extract of the fruit of Brucea javanica (Fructus Bruceae) possessed significant cytotoxicity in pancreatic adenocarcinoma cell lines.
METHODS AND RESULTS:
A bioassay-guided fractionation and purification resulted in the isolation and characterization of seven quassinoids including brusatol, bruceine D, bruceine H, Yadanzioside A, yadanzioside G, javanicoside C and bruceantinoside A.
CONCLUSIONS:
Among them, brusatol exhibited the most potent in vitro antipancreatic cancer action, with IC(50) values of 0.36 μm and 0.10 μm on PANC-1 and SW1990 cell lines, respectively. This is the first report on the antipancreatic adenocarcinoma activity of brusatol.
Yadanzioside A Description
Source: The seeds of Brucea javanica.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.4605 mL 7.3027 mL 14.6054 mL 29.2107 mL 36.5134 mL
5 mM 0.2921 mL 1.4605 mL 2.9211 mL 5.8421 mL 7.3027 mL
10 mM 0.1461 mL 0.7303 mL 1.4605 mL 2.9211 mL 3.6513 mL
50 mM 0.0292 mL 0.1461 mL 0.2921 mL 0.5842 mL 0.7303 mL
100 mM 0.0146 mL 0.073 mL 0.1461 mL 0.2921 mL 0.3651 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Chemical & pharmaceutical bulletin, 1984, 32(11), 4702-5.
New quassinoid glycosides, yadanziosides A-H, from Brucea javanica.[Reference: WebLink]
Eight new antileukemic quassinoid glycosides, Yadanzioside A, yadanzioside B, yadanzioside C, yadanzioside D, yadanzioside E, Yadanzioside F, yadanzioside G, and yadanzioside H(1-8) were isolated from seeds of Brucea javanica and their structures were determined by chemical transformation and spectral analysis.
Bull. Chem. Soc. Jpn.,1985, 58(9), 2680-6.
Structures of new quassinoid glycosides, yadanziosides A,B,C,D,E,G,H, and new quassinoids, dehydrobrusatol and dehydrobruceantinol from Brucea javanica (L.) Merr.[Reference: WebLink]

METHODS AND RESULTS:
Quassinoid glycosides, Yadanzioside A, yadanzioside B, yadanzioside C, yadanzioside D, yadanzioside E, yadanzioside G, and yadanzioside H, and two quassinoids, dehydrobrusatol and dehydrobruceantinol were isolated from seeds of Brucea javanica, and their structures were determined.
CONCLUSIONS:
These glycosides showed bitter taste and were demonstrated to have antileukemic activity.
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