(Z)-3-Hydroxy-5-methoxystilbene | CAS:143207-76-5

(Z)-3-Hydroxy-5-methoxystilbene

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Description:

3-Hydroxy-5-methoxystilbene exhibits in vitro anti-mycobacterium activity against Mycobacterium tuberculosis H37Ra with IC50 values of 3.33 ug/mL in dormant phase and 3.33 ug/mL in active phase.

Targets:

Antifection

In vitro:

Nat Prod Res. 2015;29(22):2080-6

A new butenolide cinnamate and other biological active chemical constituents from Polygonum glabrum.[Pubmed: 25643642 ]

METHODS AND RESULTS:
Phytochemical investigation of the methanol extract of the aerial parts of Polygonum glabrum afforded one new natural product (-)-2-methoxy-2-butenolide-3-cinnamate (1) along with six known compounds, β-hydroxyfriedalanol (2), 3-hydroxy-5-methoxystilbene (3), (-) pinocembrin (4), sitosterol-(6'-O-palmitoyl)-3-O-β-D-glucopyranoside (5), (-) pinocembrin-5-methyl ether (6) and sitosterol-3-O-β-D-glucopyranoside (7).
CONCLUSIONS:
Compound 1 showed promising in vitro anti-HIV-1 activity against primary isolates HIV-1(UG070) (X4, subtype D) and HIV-1(VB59) (R5, subtype C) assayed using TZM-bl cell line with IC50 in the range of 15.68-22.43 μg/mL. The extract showed TI in the range of 19.19-27.37 with IC50 in the range of 10.90-15.55 μg/mL. Compounds 1, 3 and 4 exhibited in vitro anti-mycobacterium activity against Mycobacterium tuberculosis H37Ra with IC50 values of 1.43, 3.33 and 1.11 μg/mL in dormant phase and 2.27, 3.33 and 1.21 μg/mL in active phase, respectively. Compound 4 was found to be the most active antiproliferative with IC50 values of 1.88-11.00 μg/mL against THP-1, A549, Panc-1, HeLa and MCF7 cell lines.

(Z)-3-Hydroxy-5-methoxystilbene Description

Source:	The aerial parts of Polygonum glabrum.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	(Z)-3-Hydroxy-5-methoxystilbene
Price:
CAS No.:	143207-76-5
Catalog No.:	CFN96398
Molecular Formula:	C₁₅H₁₄O₂
Molecular Weight:	226.3 g/mol
Purity:	>=98%
Type of Compound:	Phenols
Physical Desc.:	Oil
Source:	The aerial parts of Polygonum glabrum.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antibacterial Compound Library Phenols Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.4189 mL	22.0946 mL	44.1891 mL	88.3783 mL	110.4728 mL
5 mM	0.8838 mL	4.4189 mL	8.8378 mL	17.6757 mL	22.0946 mL
10 mM	0.4419 mL	2.2095 mL	4.4189 mL	8.8378 mL	11.0473 mL
50 mM	0.0884 mL	0.4419 mL	0.8838 mL	1.7676 mL	2.2095 mL
100 mM	0.0442 mL	0.2209 mL	0.4419 mL	0.8838 mL	1.1047 mL

CFN95968	4-Methoxy-9,10-dihydrophenanthrene-2,7-di-O-beta-D-glucopyranoside	1454585-37-5	566.6	C₂₇H₃₄O₁₃
CFN91418	Batatasin I	51415-00-0	284.3	C₁₇H₁₆O₄
CFN92692	Flavidinin	83925-00-2	254.3	C₁₆H₁₄O₃
CFN92691	Agrostophyllidin	178439-50-4	284.3	C₁₇H₁₆O₄
CFN92781	Phoyunnanin C	956344-38-0	482.5	C₃₀H₂₆O₆
CFN92782	Flavanthrin	120090-80-4	482.5	C₃₀H₂₆O₆
CFN95333	Diosniposide B	N/A	450.4	C₂₂H₂₆O₁₀
CFN90814	Dehydroeffusol	137319-34-7	250.3	C₁₇H₁₄O₂
CFN90815	Effusol	73166-28-6	252.3	C₁₇H₁₆O₂
CFN95143	Dehydrojuncusol	117824-04-1	264.3	C₁₈H₁₆O₂