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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $44.7 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
J of Applied Pharmaceutical Scien...2020...J of the Society of Cosmetic Scie...2018...Biomed Pharmacother.2021, 139:111585. Exp Mol Med.2020, 52(4):629-642.Cell.2018, 172(1-2):249-261Appl Biochem Biotechnol....2020...Antiviral Res.2021, 193:105142. Molecules.2021, 26(6):1738.
J Agric Food Chem....2021...Environ Toxicol.2020, doi: 10.1002J Cell Mol Med.2018, 22(9):4236-4242BMC Complement Altern Med....2017...Chem Biol Interact.2018, 283:59-74Molecules.2019, 24(11):E2044Int J Mol Sci.2021, 22(19):10405.Res Rep Urol.2022, 14:313-326.
Food Res Int.2021, 148:110607.Pak J Pharm Sci.2019, 32(6)Anal Bioanal Chem....2020...Phytochem Anal.2013, 24(5):493-503J Microbiol Biotechnol....2020...Anticancer Res.2022, 42(9):4403-4410.Emirates Journal of Food and Agri...2022...
Our products had been exported to the following research institutions and universities, And still growing.
Anna University (India)Universitas Airlangga (Indonesia)University of Liège (Belgium)Vin?a Institute of Nuclear Scie... (Serbia)
Weizmann Institute of Science (Israel)Stanford University (USA)Griffith University (Australia)Uniwersytet Jagielloński w Kra... (Poland)
Mahatma Gandhi University (India)Leibniz-Institut für Pflanzenb... (Germany)Universiti Sains Malaysia (Malaysia)
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Front Aging Neurosci.2019, 11:230Fitoterapia.2015, 100:179-86J Ethnopharmacol.2020, 269:113752. Food Chem.2019, 274:345-350Food Research2021, 5(1):65-71Nutrients.2020, 12(11):3448. Front Cell Dev Biol.2021, 9:764263.J Sci Food Agric.2023, 103(1):213-220.Sci Rep.2019, 9(1):18080Front Pharmacol.2016, 7:460
Related Screening Libraries
||Ziyuglycoside I has anti-wrinkle activity, could be used as an active ingredient for cosmetics.|
|Biosci Biotechnol Biochem. 2008 Feb;72(2):303-11. |
|Anti-wrinkle activity of ziyuglycoside I isolated from a Sanguisorba officinalis root extract and its application as a cosmeceutical ingredient.[Pubmed: 18256460]|
|In order to investigate the potential of a Sanguisorba officinalis root extract as an active ingredient for wrinkle-care cosmetics, we measured its free radical scavenging activity, elastase inhibitory activity, expression of MMP-1 (matrix metalloprotease-1) in vitro, and type I collagen synthesis in normal human fibroblast cells.
METHODS AND RESULTS:
To isolate the main components from the S. officinalis root extract, we purified the extract by solvent fractionation, column chromatography, and recrystallization. The active component was identified as Ziyuglycoside I by a spectroscopic analysis. Ziyuglycoside I increased the expression of type I collagen in a dose-dependent manner (by up to 71.3% at 50 muM). A clinical study of a formulation containing Ziyuglycoside I, which involved visual evaluation and image analysis, showed a significantly different effect (p<0.05) of the test formulation from that of the placebo.
This result suggests that Ziyuglycoside I isolated from S. officinalis root extract could be used as an active ingredient for cosmetics.
|Int J Mol Sci . 2016 Nov 22;17(11):1903. |
|Ziyuglycoside I Inhibits the Proliferation of MDA-MB-231 Breast Carcinoma Cells through Inducing p53-Mediated G2/M Cell Cycle Arrest and Intrinsic/Extrinsic Apoptosis[Pubmed: 27879682]|
Background: Due to the aggressive clinical behavior, poor outcome, and lack of effective specific targeted therapies, triple-negative breast cancer (TNBC) has currently been recognized as one of the most malignant types of tumors. In the present study, we investigated the cytotoxic effect of Ziyuglycoside I, one of the major components extracted from Chinese anti-tumor herbal Radix Sanguisorbae, on the TNBC cell line MDA-MB-231.
Methods: The underlying molecular mechanism of the cytotoxic effect Ziyuglycoside I on MDA-MB-231 cells was investigated with cell viability assay, flow cytometric analysis and Western blot.
Results: Compared to normal mammary gland Hs 578Bst cells, treatment of Ziyuglycoside I resulted in a significant growth inhibitory effect on MDA-MB-231 cells. Ziyuglycoside I induced the G2/M phase arrest and apoptosis of MDA-MB-231 cells in a dose-dependent manner. These effects were found to be partially mediated through the up-regulation of p53 and p21WAF1, elevated Bax/Bcl-2 ratio, and the activation of both intrinsic (mitochondrial-initiated) and extrinsic (Fas/FasL-initiated) apoptotic pathways. Furthermore, the p53 specific siRNA attenuated these effects.
Conclusion: Our study suggested that Ziyuglycoside I-triggered MDA-MB-231 cell cycle arrest and apoptosis were probably mediated by p53. This suggests that Ziyuglycoside I might be a potential drug candidate for treating TNBC.
Keywords: G2/M phase arrest; MDA-MB-231 cell line; intrinsic and extrinsic apoptosis; Ziyuglycoside I.|
Ziyuglycoside I Description
||The roots of Sanguisorba officinalis.
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|J Sep Sci. 2015 Apr 17. |
|Development and validation of a quantification method for ziyuglycoside I and II in rat plasma: Application to their pharmacokinetic studies.[Pubmed: 25885584]|
|This study provided a novel and generally applicable method to determine Ziyuglycoside I and Ziyuglycoside II in rat plasma based on liquid chromatography with tandem mass spectrometry.
METHODS AND RESULTS:
A single step of liquid-liquid extraction with n-butanol was utilized, and ginsenoside Rg3 was chosen as internal standard. Final extracts were analyzed based on liquid chromatography with tandem mass spectrometry. Chromatographic separation was achieved using a Thermo Golden C18 column, and the applied gradient elution program allowed for the simultaneous determination of two ziyuglycosides in a one-step chromatographic separation with a total run time of 10 min. The fully validated methodology for both analytes demonstrated high sensitivity (the lower limit of quantitation was 2.0 ng/mL), good accuracy (% RE ≤ ± 15) and precision (% RSD ≤ 15). The average recoveries of both ziyuglycosides and internal standard were all above 75% and no obvious matrix effect was found. This method was then successfully applied to the preclinical pharmacokinetic studies of Ziyuglycoside I and Ziyuglycoside II.
The presently developed methodology would be useful for the preclinical and clinical pharmacokinetic studies for Ziyuglycoside I and Ziyuglycoside II.
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