ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
More articles cited ChemFaces products.
BMC Complement Altern Med.2014 Sep 23;14:352.Anal Bioanal Chem.2018 Feb;Molecules. 2017 Mar 7;New Zealand Journal of Forestry Sci.2014, 44:17J Ethnopharmacol. 2017 Feb 2;
Biol Pharm Bull. 2018;41(1):65-72.JPCJuly 12, 2017J Med Food. 2016 Dec;19(12)Korean J. of Food Sci. and TechApril 2016Free Radic Biol Med.2016 Jun 25;97:307-319.
British Jou. Med. & Med. Research2014 Jan 1Mol Cells.2015 Sep 30;38(9):765-72.Int J Mol Sci. 2018 Jan 23;Hindawi Publishing Corporation2015 July 30
Our products had been exported to the following research institutions and universities, And still growing.
Universite Libre de Bruxelles (Belgium)Max Rubner-Institut (MRI) (Germany)Leibniz-Institut für Pflanzenbi... (Germany)Universiti Malaysia Pahang (Malaysia)
University of Wollongong (Australia)The Vancouver Prostate Centre (V... (Canada)Istanbul University (Turkey)Macau University of Science and ... (China)
Cornell University (USA)University of Bonn (Germany)Indian Institute of Science (India)
||Demethylwedelolactone has trypsin inhibitory effect, it exerts anti-invasive growth effect on breast cancer cells.|
||NF-kB | IkB | MEK | ERK | MMP(e.g.TIMP) | IKK|
|Phytother Res. 2003 Apr;17(4):420-1. |
|Trypsin inhibitory effect of wedelolactone and demethylwedelolactone.[Pubmed: 12722155]|
| Wedelolactone (WL) and Demethylwedelolactone (DWL) isolated from Eclipta alba were tested in the trypsin inhibition bioassay (in vitro). |
METHODS AND RESULTS:
Both compounds showed potent activity. IC(50) values of WL and DWL were found to be 2.9 and 3.0 microg/mL respectively.
|Eur J Med Chem. 2012 Oct;56:361-7. |
|Demethylwedelolactone derivatives inhibit invasive growth in vitro and lung metastasis of MDA-MB-231 breast cancer cells in nude mice.[Pubmed: 22926226]|
|The anticancer properties of Demethylwedelolactone (DWEL) and wedelolactone (WEL), which are naturally occurring coumestans, have not been well characterized. In this study, we investigated the anti-invasive effects of synthetic WEL and Demethylwedelolactone on human MDA-MB-231 breast cancer cells. |
METHODS AND RESULTS:
We found that WEL and Demethylwedelolactone inhibited the anchorage-independent growth and also suppressed cell motility and cell invasion of MDA-MB-231 cells. In addition, WEL and Demethylwedelolactone reduced the activity and expression of matrix metalloproteinases (MMPs) involved in blocking the IκB-α/NFκB and MEK/ERK signaling pathways in MDA-MB-231 cells. Furthermore, Demethylwedelolactone suppressed the metastasis and lung colonization of the tumor cells in the nude mice.
Altogether, these data suggest that Demethylwedelolactone derivatives exert anti-invasive growth effect on breast cancer cells.
||The herbs of Eclipta prostrata
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi:10.1016/j.phymed.2017.12.030PMID: 29496173
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.