Demethylwedelolactone | CAS:6468-55-9 | Manufacturer ChemFaces

Demethylwedelolactone

ChemFaces products have been cited in many studies from excellent and top scientific journals

Product Name	Demethylwedelolactone
Price:	$320 / 20mg
CAS No.:	6468-55-9
Catalog No.:	CFN90521
Molecular Formula:	C₁₅H₈O₇
Molecular Weight:	300.21 g/mol
Purity:	>=98%
Type of Compound:	Coumarins
Physical Desc.:	Yellow powder
Source:	The herbs of Eclipta prostrata
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC

How to Order

Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com

Delivery time

Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal

Citing Use of our Products

More Impact Factor than five Cite...

* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.

According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $78.3 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

Featured Products

More...

Astragaloside III

Catalog No: CFN99174
CAS No: 84687-42-3
Price: $268/20mg

Hyperoside

Catalog No: CFN98754
CAS No: 482-36-0
Price: $50/20mg

Isorhamnetin-3-O-beta-D-Glucoside

Catalog No: CFN99757
CAS No: 5041-82-7
Price: $218/10mg

3-oxo-Olean-12-en-28-oic acid

Catalog No: CFN92194
CAS No: 17990-42-0
Price: $90/20mg

Ursolic acid

Catalog No: CFN97259
CAS No: 77-52-1
Price: $30/20mg

(+)-Syringaresinol

Catalog No: CFN89209
CAS No: 21453-69-0
Price: $ / mg

Dihydrotanshinone I

Catalog No: CFN97435
CAS No: 87205-99-0
Price: $60/20mg

1,2,3,4,6-O-Pentagalloylglucose

Catalog No: CFN90192
CAS No: 14937-32-7
Price: $80/20mg

Chicoric acid

Catalog No: CFN99725
CAS No: 6537-80-0
Price: $70/20mg

Luteolin-6-C-glucoside

Catalog No: CFN98137
CAS No: 4261-42-1
Price: $128/20mg

Description:

Demethylwedelolactone has trypsin inhibitory effect, it exerts anti-invasive growth effect on breast cancer cells.

Targets:

NF-kB | IkB | MEK | ERK | MMP(e.g.TIMP) | IKK

In vitro:

Phytother Res. 2003 Apr;17(4):420-1.

Trypsin inhibitory effect of wedelolactone and demethylwedelolactone.[Pubmed: 12722155]

Wedelolactone (WL) and Demethylwedelolactone (DWL) isolated from Eclipta alba were tested in the trypsin inhibition bioassay (in vitro).
METHODS AND RESULTS:
Both compounds showed potent activity. IC(50) values of WL and DWL were found to be 2.9 and 3.0 microg/mL respectively.

Eur J Med Chem. 2012 Oct;56:361-7.

Demethylwedelolactone derivatives inhibit invasive growth in vitro and lung metastasis of MDA-MB-231 breast cancer cells in nude mice.[Pubmed: 22926226]

The anticancer properties of Demethylwedelolactone (DWEL) and wedelolactone (WEL), which are naturally occurring coumestans, have not been well characterized. In this study, we investigated the anti-invasive effects of synthetic WEL and Demethylwedelolactone on human MDA-MB-231 breast cancer cells.
METHODS AND RESULTS:
We found that WEL and Demethylwedelolactone inhibited the anchorage-independent growth and also suppressed cell motility and cell invasion of MDA-MB-231 cells. In addition, WEL and Demethylwedelolactone reduced the activity and expression of matrix metalloproteinases (MMPs) involved in blocking the IκB-α/NFκB and MEK/ERK signaling pathways in MDA-MB-231 cells. Furthermore, Demethylwedelolactone suppressed the metastasis and lung colonization of the tumor cells in the nude mice.
CONCLUSIONS:
Altogether, these data suggest that Demethylwedelolactone derivatives exert anti-invasive growth effect on breast cancer cells.

Demethylwedelolactone Description

Source:	The herbs of Eclipta prostrata
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Anti-inflammatory Compound Library Inhibitors Compound Library Immunomodulators Compound Library Anti-venom Compound Library Coumarins Compound Library NF-kB Inhibitor Library MMP(e.g.TIMP) Inhibitor Library MEK Inhibitor Library IKK Inhibitor Library IkB Inhibitor Library ERK Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.331 mL	16.655 mL	33.31 mL	66.62 mL	83.275 mL
5 mM	0.6662 mL	3.331 mL	6.662 mL	13.324 mL	16.655 mL
10 mM	0.3331 mL	1.6655 mL	3.331 mL	6.662 mL	8.3275 mL
50 mM	0.0666 mL	0.3331 mL	0.6662 mL	1.3324 mL	1.6655 mL
100 mM	0.0333 mL	0.1666 mL	0.3331 mL	0.6662 mL	0.8328 mL

CFN95072	Licoarylcoumarin	125709-31-1	368.4	C₂₁H₂₀O₆
CFN96040	Coumestrol	479-13-0	268.2	C₁₅H₈O₅
CFN96922	4'-O-Methylcoumestrol	1690-62-6	282.25	C₁₆H₁₀O₅
CFN90521	Demethylwedelolactone	6468-55-9	300.21	C₁₅H₈O₇
CFN98857	Wedelolactone	524-12-9	314.3	C₁₆H₁₀O₇
CFN90625	Isodemethylwedelolacton	350681-33-3	300.22	C₁₅H₈O₇
CFN98592	Psoralidin	18642-23-4	336.34	C₂₀H₁₆O₅
CFN90792	Neoglycyrol	23013-84-5	366.4	C₂₁H₁₈O₆
CFN89408	Glycycoumarin	94805-82-0	368.37	C₂₁H₂₀O₆
CFN89404	Glycyrin	66056-18-6	382.40	C₂₂H₂₂O₆