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    Pendulone
    Pendulone
    Information
    CAS No. 69359-09-7 Price $413 / 5mg
    Catalog No.CFN91031Purity>=98%
    Molecular Weight316.31Type of CompoundFlavonoids
    FormulaC17H16O6Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Our products had been exported to the following research institutions and universities, And still growing.
  • Universidade do Porto (Portugal)
  • Molecular Biology Institute of B... (Spain)
  • University of Zurich (Switzerland)
  • University of Hawaii Cancer Center (USA)
  • Seoul National University (Korea)
  • National Cancer Center Research ... (Japan)
  • Medizinische Universit?t Wien (Austria)
  • Amity University (India)
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  • Package
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    Biological Activity
    Description: 1. Pendulone exhibits good anti-plasmodial activity with the IC50 value of 7.0 ± 0.8 uM.
    2. Pendulone displays antibacterial activity against Staphylococcus aureus and methicillin-resistant S. aureus (each IC50 1.44 microg/mL).
    3. Pendulone shows potent leishmanicidal activity.
    4. Pendulone could be a valuable chemopreventive agent, it shows strong inhibition on the effect of the cell cycle induced by TPA and shows potent anti-tumor-promoting activity for an in vivo two-stage carcinogenesis test.
    Targets: Antifection
    Pendulone Description
    Source: The herbs of Millettia dielsiana
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
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    doi: 10.1038/s41598-017-17427-6.

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    J Cell Biochem. 2018 Feb;119(2):2231-2239.
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    Phytomedicine. 2018 Feb 1;40:37-47.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.1615 mL 15.8073 mL 31.6146 mL 63.2291 mL 79.0364 mL
    5 mM 0.6323 mL 3.1615 mL 6.3229 mL 12.6458 mL 15.8073 mL
    10 mM 0.3161 mL 1.5807 mL 3.1615 mL 6.3229 mL 7.9036 mL
    50 mM 0.0632 mL 0.3161 mL 0.6323 mL 1.2646 mL 1.5807 mL
    100 mM 0.0316 mL 0.1581 mL 0.3161 mL 0.6323 mL 0.7904 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Pendulone References Information
    Citation [1]

    Planta Med. 2015 Aug;81(12-13):1128-32.

    Antiplasmodial Isoflavanes and Pterocarpans from Apoplanesia paniculata.[Pubmed: 26018916]
    Bioassay-guided fractionation of an EtOH extract of the roots of the plant Apoplanesia paniculata (Fabaceae) led to the isolation of the three known compounds amorphaquinone (1), Pendulone (2), and melilotocarpan C (3), and the two new pterocarpans 4 and 5. Compounds 1 and 2 exhibited good antiplasmodial activity with IC50 values of 5.7 ± 1.5 and 7.0 ± 0.8 μM, respectively. Compound 3 exhibited weak antiplasmodial activity (41.8 ± 5.2 μM), while compounds 4 and 5 were inactive. Compound 6 was synthesized to confirm the structure of 5, and it showed enhanced antiplasmodial activity (15.8 ± 1.4 μM) compared to its analogues 3-5.
    Citation [2]

    Nat Prod Commun. 2011 Nov;6(11):1645-50.

    Antiparasitic and antimicrobial isoflavanquinones from Abrus schimperi.[Pubmed: 22224279]
    The EtOH extract of Abrus schimperi (Fabaceae), collected in Kenya, demonstrated significant activity against Leishmania donovani promastigotes with IC50 value of 3.6 microg/mL. Bioassay-guided fractionation of CHCl3 fraction using Centrifugal Preparative TLC afforded two antiparasitic isoflavanquinones, namely amorphaquinone (1) and Pendulone (2). They displayed IC50 values of 0.63 microg/mL and 0.43 microg/mL, respectively, against L. donovani promastigotes. Both the compounds were also evaluated against L. donovani axenic amastigotes and amastigotes in THPI macrophage cultures. In addition, compounds 1 and 2 showed antiplasmodial activity against Plasmodium falciparum D6 and W2 strains, while 2 displayed antibacterial activity against Staphylococcus aureus and methicillin-resistant S. aureus (each IC50 1.44 microg/mL). The 1H and 13C data of 1, not fully assigned previously, were unambiguously assigned using 1D and 2D NMR HMBC and HMQC experiments. In addition, the absolute stereochemistry of the isolated compounds 1 and 2 was revised as C-(3S) based on Circular Dichroism experiments. This appears to be the first report of amorphaquinone (1) and Pendulone (2) from the genus Abrus.
    Citation [3]

    Chem Pharm Bull (Tokyo). 2006 Jun;54(6):915-7.

    In vitro leishmanicidal constituents of Millettia pendula.[Pubmed: 16755071]
    The in vitro leishmanicidal constituents of Millettia pendula were examined. Two new compounds, 1 (millettilone A) and 2 (millettilone B), were isolated from the methanol extract of M. pendula, together with six known compounds: 3R-claussequinone (3), Pendulone (4), secundiflorol I (5), 3,8-dihydroxy-9-methoxypterocarpan (6), 3,10-dihydroxy-7,9-dimethoxypterocarpan (7), and formononetin (8). Among these, Pendulone showed the most potent leishmanicidal activity. Compound 2 was found to be a purple pigment in this heartwood. Their chemical structures were elucidated using spectral methods.
    Citation [4]

    Biol Pharm Bull. 1997 Aug;20(8):865-8.

    Anti-tumor promoting activities of isoflavonoids from Wistaria brachybotrys.[Pubmed: 9300132]
    Eight minor isoflavonoids (3-10) isolated from the knot of Wistaria brachybotrys were tested for their inhibitory effects on Epstein-Barr virus (EBV) activation induced by the tumor promoter, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), in Raji cells as a primary screening test for anti-tumor-promoters (cancer chemopreventive agents), and all the tested compounds showed inhibitory activity. Of these compounds, Pendulone (3) was further examined on the cell cycle of Raji cells, and indicated strong inhibition on the effect of the cell cycle induced by TPA. In addition, the compound showed potent anti-tumor-promoting activity for an in vivo two-stage carcinogenesis test of mouse skin using 7,12-dimethylbenz[a]-anthracene and TPA. Consequently, it suggests that 3 could be a valuable chemopreventive agent in chemical carcinogenesis.