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    Natural Products
    S-Adenosyl-L-Methtonine
    S-Adenosyl-L-Methtonine
    Information
    CAS No. 17176-17-9 Price $70 / 20mg
    Catalog No.CFN90075Purity>=98%
    Molecular Weight398.44Type of CompoundAlkaloids
    FormulaC15H22N6O5SPhysical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $25.1 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
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    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
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    Related Libraries
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  • Biological Activity
    Description: S-Adenosyl-L-methionine, L-methionine, and N-acetylcysteine exert various degrees of protection toward ethanol-induced cell injury, which are related to the efficiency of these compounds in maintaining a high glutathione pool.
    Targets: Sodium Channel | ATPase | Potassium Channel
    In vivo:
    Toxicol Appl Pharmacol. 1989 Feb;97(2):216-29.
    Inhibition by ethanol of rat liver plasma membrane (Na+,K+)ATPase: protective effect of S-adenosyl-L-methionine, L-methionine, and N-acetylcysteine.[Pubmed: 2538005]

    METHODS AND RESULTS:
    S-adenosyl-L-methionine(S-Adenosyl-L-Methtonine,SAM), L-methionine, and N-acetylcysteine (NAC), given to rats during ethanol treatment, prevented the decrease in (Na+,K+)ATPase activity and GSH content. They also reduced steatosis and liver necrosis. The efficiency of these compounds decreased in this order: SAM, methionine, NAC. SAM accelerated the recovery of all parameters studied after ethanol withdrawal, and also protected (Na+,K+)ATPase activity and GSH content of isolated hepatocytes from the deleterious effect of ethanol. These SAM effects were prevented by 1-chloro-2,4-dinitro-benzene, a compound which depletes cell GSH. Treatment of isolated hepatocytes with [35S]SAM led to the synthesis of labeled GSH. The total amount and specific activity of labeled GSH underwent a significant increase, in the presence of 2 mM ethanol or 0.5 mM ACA, which indicates a marked stimulation of GSH synthesis by ethanol and ACA.
    CONCLUSIONS:
    These data indicate that ethanol intoxication may inhibit (Na+,K+)ATPase activity; an effect that does not seem to depend on cell necrosis. SAM, methionine, and NAC exert various degrees of protection toward ethanol-induced cell injury, which are related to the efficiency of these compounds in maintaining a high GSH pool.
    S-Adenosyl-L-Methtonine Description
    Source:
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.5098 mL 12.5489 mL 25.0979 mL 50.1958 mL 62.7447 mL
    5 mM 0.502 mL 2.5098 mL 5.0196 mL 10.0392 mL 12.5489 mL
    10 mM 0.251 mL 1.2549 mL 2.5098 mL 5.0196 mL 6.2745 mL
    50 mM 0.0502 mL 0.251 mL 0.502 mL 1.0039 mL 1.2549 mL
    100 mM 0.0251 mL 0.1255 mL 0.251 mL 0.502 mL 0.6274 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.