ChemFaces is a professional high-purity natural products manufacturer.
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2. Pharmacological research
Citing Use of our Products
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Inflammation2015, 38(1):445-55Free Radic Biol Med.2016, 97:307-319Molecular & Cellular Toxicology...2017...Exp Parasitol.2017, 183:160-166J of L. Chroma.&Related Tech...2017...J Agric Food Chem....2017...Mol Cell.2017, 68(4):673-685J Nat Med.2017, 71(2):380-388
Drug Test Anal.2018, 10(10):1579-1589Pharmacognosy Magazine...2018...Life Sci.2018, 209:498-506Molecules.2018, 23(12):E3103Food Chem.2018, 252:207-214Phytomedicine.2018, 47:48-57Korean Journal of Pharmacognosy...2018...Planta Med.2018, 84(6-07):465-474
J Sci Food Agric.2018, 98(3):1153-1161Front Pharmacol.2019, 10:1025Postharvest Biol Tec2019, 149:18-26Chemistry of Vegetable Raw Materi...2019...Pak J Pharm Sci.2019, 32(6):2879-2885Phytomedicine.2019, 56:48-56Int Immunopharmacol.2019, 71:361-371
Our products had been exported to the following research institutions and universities, And still growing.
University of Eastern Finland (Finland)Utah State University (USA)Johannes Gutenberg University M... (Germany)Lund University (Sweden)
Universita' Degli Studi Di Cagl... (Italy)University of the Basque Country (Spain)Universiti Kebangsaan Malaysia (Malaysia)Periyar University (India)
Amity University (India)University of Minnesota (USA)Aarhus University (Denmark)
Related Screening Libraries
||Vasicinol shows a high sucrase inhibitory activity, and the IC50 values was 250 μM.vasicinol could be an useful treatment for metabolic disorders.Vasicinol and vasicinone severe antifertility effects are exhibited by vasicinol against Dysdercus skoenigii and Tribolium castaneum due to blocking of oocytes in the oviduct.|
||The leaves of Adhatoda vasica Nees
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Food Chem. 2008 Jun 1;108(3):965-72. |
|Inhibitory effect on α-glucosidase by Adhatoda vasica Nees.[Pubmed: 26065759]|
|Methanolic extracts from the medicinal parts of 40 traditional Chinese herbs were tested in screening experiments for rat intestinal α-glucosidase.
METHODS AND RESULTS:
The methanolic extract from the leaves of Adhatoda vasica Nees (Acanthaceae) showed the highest sucrase inhibitory activity with sucrose as a substrate. Enzyme assay-guided fractionation of this extract afforded vasicine (1) and Vasicinol (2), and the structures of these compounds were elucidated on the basis of MS and NMR analysis. Compounds 1 and 2 showed a high sucrase inhibitory activity, and the IC50 values were 125μM and 250μM, respectively. Both 1 and 2 were shown to be reversible inhibitors of sucrase. Kinetic data revealed that compounds 1 and 2 inhibited sucrose-hydrolysing activity of rat intestinal α-glucosidase competitively with Ki values of 82μM and 183μM, respectively. This is the first report on the mammalian α-glucosidase inhibition of A. vasica and the inhibitory effect on sucrase by 1 and 2 from this herb species.
These results suggest a use of the extract of A. vasica as an antidiabetic agent and show a possibility that compounds 1 and 2 could be an useful treatment for metabolic disorders.
| Tetrahedron: Asymmetry, 1996,7(1):25–28. |
|Reversal of absolute stereochemistry of the pyrrolo[2,1-b]quinazoline alkaloids vasicine, vasicinone, vasicinol and vasicinolone[Reference: WebLink]|
METHODS AND RESULTS:
The previously assigned 3R configuration of (−)-vasicinone has been reversed and this pyrrolo[2,1-b]quinazoline-9-one has been shown to have the 3S-configuration (3) on the basis of an X-ray diffraction study of (+)-vasicinone hydrobromide. Likewise, the 3R stereochemistry assigned earlier to (−)-vasicine (peganine) (1) on the basis of an X-ray analysis of its hydrochloride has also been reversed by reinvestigation of the X-ray diffraction analysis of the hydrobromide. The absolute stereochemistry of the alkaloids (+)-Vasicinol (2) and Vasicinolone (5) which have been inter-related, should also have the 3S-configuration.
A study of the 1H nmr spectroscopy of (−)-vasicine by the use of Mosher's method using MTPA [α-methoxy-α-(trifluoromethyl)phenylacetic acid] esters indicated an exception to this model for establishing the absolute configuration.