1-Methoxyindole-3-carboxylic acid | CAS:91913-76-7

1-Methoxyindole-3-carboxylic acid

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Description:

Standard reference

In vitro:

Xenobiotica. 1991 May;21(5):569-74.

In vitro O-demethylation from a heterocyclic nitrogen: a novel metabolic reaction?[Pubmed: 1949889]

METHODS AND RESULTS:
1. O-Demethylation of 1-Methoxyindole-3-carboxylic acid, in vitro, by determination of liberated formaldehyde, has been demonstrated using fortified 15,000 g rat liver supernatant fraction. 2. Results have been compared to those similarly obtained with a standard O-demethylation substrate, 4-nitroanisole, to substantiate and quantify the extent of the reaction. 3. Km values for 4-nitroanisole and methoxyindole-3-carboxylic acid were 8.9 and 6.5 mM, while Vmax values were 4.9, and 5.2 nmol HCHO produced/mg protein per min.
CONCLUSIONS:
4. The significance of the metabolic O-demethylation reaction for N-methoxyindoles as a novel metabolic pathway is discussed in terms of pharmacological activity and biological reactivity.

1-Methoxyindole-3-carboxylic acid Description

Source:	The herbs of Isatis indigotica
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	1-Methoxyindole-3-carboxylic acid
Price:
CAS No.:	91913-76-7
Catalog No.:	CFN96036
Molecular Formula:	C₁₀H₉NO₃
Molecular Weight:	191.2 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The herbs of Isatis indigotica
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	5.2301 mL	26.1506 mL	52.3013 mL	104.6025 mL	130.7531 mL
5 mM	1.046 mL	5.2301 mL	10.4603 mL	20.9205 mL	26.1506 mL
10 mM	0.523 mL	2.6151 mL	5.2301 mL	10.4603 mL	13.0753 mL
50 mM	0.1046 mL	0.523 mL	1.046 mL	2.0921 mL	2.6151 mL
100 mM	0.0523 mL	0.2615 mL	0.523 mL	1.046 mL	1.3075 mL

CFN90634	Hypaphorine	487-58-1	246.3	C₁₄H₁₈N₂O₂
CFN90473	Tryptophan	54-12-6	204.22	C₁₁H₁₂N₂O₂
CFN95964	L-Tryptophan methyl ester	4299-70-1	218.3	C₁₂H₁₄N₂O₂
CFN70337	N-Malonyl DL-tryptophan	3184-74-5	290.3	C₁₄H₁₄N₂O₅
CFN95940	N-Caffeoyltryptophan	109163-69-1	366.4	C₂₀H₁₈N₂O₅
CFN95941	Na-p-Hydroxycoumaroyltryptophan	171741-93-8	350.4	C₂₀H₁₈N₂O₄
CFN99742	5-Hydroxytryptophan	56-69-9	220.23	C₁₁H₁₂N₂O₃
CFN94005	Nb-Feruloyltryptamine	53905-13-8	336.39	C₂₀H₂₀N₂O₃
CFN94006	Moschamine	68573-23-9	352.39	C₂₀H₂₀N₂O₄
CFN94007	cis-Moschamine	193224-24-7	352.39	C₂₀H₂₀N₂O₄