ChemFaces is a professional high-purity natural products manufacturer.
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Arch Pharm Res.2015, 38(6):1080-9Oncol Rep.2016, 35(3):1356-64J Pharm Biomed Anal.2017, 140:274-280Korean J. of Horticultural Sci. &...2017...Appl Microbiol Biotechnol....2018...J of Engineering Science&Technolo...2018...Journal of functional foods...2018...BMC Plant Biol.2018, 18(1):122
Phytomedicine.2018, 38:45-56Sci Adv.2018, 4(10)BMB Rep.2018, 51(5):249-254Front Immunol.2018, 9:2091Journal of Life Science2018, 917-922J Mol Med (Berl).2018, 96(7):661-672Chemistry of Plant Materials....2019...Molecules.2019, 24(10):E1926
Cell Mol Biol(Noisy-le-grand)...2019...Planta Med.2019, 85(9-10):766-773Biomed Pharmacother.2020, 131:110673.Molecules.2020, 25(11):2599. Anal Bioanal Chem....2020...American Association for Anatomy...2020...Phytomedicine.2021, 2(82):153452
Our products had been exported to the following research institutions and universities, And still growing.
Universidade Federal de Goias (... (Brazil)Sant Gadge Baba Amravati Univer... (India)Fraunhofer-Institut für Moleku... (Germany)Martin Luther University of Hal... (Germany)
Universidade de Franca (Brazil)Institute of Bioorganic Chemist... (Poland)Utrecht University (Netherlands)Calcutta University (India)
Max Rubner-Institut (MRI) (Germany)Universidade do Porto (Portugal)Aarhus University (Denmark)
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Sci Rep.2019, 9(1):18080Molecules.2019, 24(20):3755Int J Biol Macromol.2019, 126:653-661Inflammation2015, 38(1):445-55J Chromatogr B Analyt Technol Biomed Life Sci.2018, 1080:27-36Biomed Pharmacother.2020, 125:109784.Inflammation.2015, 38(4):1502-16Srinagarind Medical Journal2017, 32(1)Exp Parasitol.2015, 153:160-4Curr Top Med Chem.2020, 20(21):1898-1909.
Related Screening Libraries
|| 2',3,5,7-Tetrahydroxyflavone inhibits MMP-13 expression in IL-1β-treated chondrocytes, at least in part, by suppressing the c-Fos/AP-1 and JAK2/STAT1/2 pathways. |
||c-Fos | AP-1 | STAT | MMP | JAK | IL Recepter|
||The roots of Kaempferia galangal L.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Journal of Pharmacological Sciences, 21 May 2011, 116(2):221-231. |
|Effects of flavonoids on matrix metalloproteinase-13 expression of interleukin-1β-treated articular chondrocytes and their cellular mechanisms: inhibition of c-Fos/AP-1 and JAK/STAT signaling pathways.[Reference: WebLink]|
|To identify the therapeutic potential for cartilage degradation and its action mechanisms, the effects of naturally-occurring flavonoids on matrix metalloproteinase-13 (MMP-13) induction were examined in the human chondrocyte cell line SW1353.
METHODS AND RESULTS:
Flavones including apigenin and wogonin strongly inhibited MMP-13 induction in interleukin (IL)-1β-treated SW1353 cells, while flavonols such as kaempferol, quercetin, and flavanone (naringenin) did not at 5 - 25 µM. Apigenin and wogonin primarily inhibit MMP-13 by blocking the c-Fos / activator protein-1 (AP-1) and Janus kinase 2 (JAK2) / signal transducer and activator of transcription 1/2 (STAT1/2) pathways, but not nuclear factor-κB (NF-κB) signaling. Apigenin was also shown to inhibit extracellular matrix degradation in rabbit cartilage culture. The following study using some synthetic flavones demonstrated that A-ring C-5,7-dihydroxyl and B-ring dihydroxyl substitution at C-2,3, C-2,4, or C-3,4 are important for the suppression of MMP-13 expression. Among these flavones,
2',3,5,7-Tetrahydroxyflavone also inhibited both the c-Fos/AP-1 and STAT1/2 pathways.
Taken together, these results indicate that certain flavonoids, especially flavones, inhibit MMP-13 expression in IL-1β-treated chondrocytes, at least in part, by suppressing the c-Fos/AP-1 and JAK2/STAT1/2 pathways. Furthermore, these findings suggest that some flavonoids have the potential for protecting against collagen matrix breakdown in the cartilage of diseased tissues such as those found in arthritic disorders.