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    Natural Products
    5,7-Di-O-methylquercetin
    5,7-Di-O-methylquercetin
    Information
    CAS No. 13459-07-9 Price
    Catalog No.CFN92429Purity>=98%
    Molecular Weight330.3Type of CompoundFlavonoids
    FormulaC17H14O7Physical DescriptionPowder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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    5,7-Di-O-methylquercetin

    5,7-Di-O-methylquercetin
    Product Name 5,7-Di-O-methylquercetin
    CAS No.: 13459-07-9
    Catalog No.: CFN92429
    Molecular Formula: C17H14O7
    Molecular Weight: 330.3 g/mol
    Purity: >=98%
    Type of Compound: Flavonoids
    Physical Desc.: Powder
    Source: The branches of Rhamnus cathartica
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price:
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  • J Herbmed Pharmacol.2018, 7(4):280-286
  • Molecules.2021, 26(9):2802.
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Genotoxicity Compound Library
  • Flavonoids Compound Library
  • Biological Activity
    Description: 5,7-Di-O-methylquercetin is a genotoxic compound from S. skinneri.
    In vitro:
    Mutat Res. 1978 Dec;54(3):297-309.
    Mutagenicity of plant flavonoids: structural requirements for mutagenic activity in Salmonella typhimurium.[Pubmed: 368618]

    METHODS AND RESULTS:
    40 compounds structurally related to the plant flavonol quercetin were tested for mutagenic activity in Salmonella typhimurium strain TA98. 10 flavonols, quercetin, myricetin, rhamnetin, galangin, kaempferol, tamarixetin, morin, 3'-O-methylquercetin, 7,4'-di-O-methylquercetin and 5,7-di-O-methyl-quercetin, exhibited unequivocal mutagenic activity.
    CONCLUSIONS:
    4 compounds, quercetin, myricetin, rhamnetin and 5,7-Di-O-methylquercetin, were active without metabolic activation, although metabolic activation markedly enhanced their activity.
    5,7-Di-O-methylquercetin Description
    Source: The branches of Rhamnus cathartica
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.0276 mL 15.1378 mL 30.2755 mL 60.551 mL 75.6888 mL
    5 mM 0.6055 mL 3.0276 mL 6.0551 mL 12.1102 mL 15.1378 mL
    10 mM 0.3028 mL 1.5138 mL 3.0276 mL 6.0551 mL 7.5689 mL
    50 mM 0.0606 mL 0.3028 mL 0.6055 mL 1.211 mL 1.5138 mL
    100 mM 0.0303 mL 0.1514 mL 0.3028 mL 0.6055 mL 0.7569 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Altern Lab Anim. 2002 Jan-Feb;30(1):87-92.
    Use of the SOS-chromotest spot assay as a screening system for detecting genotoxic compounds in crude plant extracts.[Pubmed: 11827573]

    METHODS AND RESULTS:
    An SOS-chromotest spot assay was used to detect genotoxic compounds in crude plant extracts. The method allows simultaneous testing of extracts from different species in either a liquid or a solid crystalline form. Extracts from two species of the genus Senna, native to the state of Morelos, Mexico, were assayed. Four genotoxic compounds were isolated, and were identified as quercetin and rutin from S. wislizeni, and 5,7-di- O-methylrutin and 5,7-Di-O-methylquercetin from S. skinneri.
    CONCLUSIONS:
    The SOS-chromotest spot assay proved to be useful for activity- guided fractionation at the beginning of screening for genotoxic compounds in crude plant extracts.
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