ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
3. Inhibitors
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $270.3 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Antioxidants (Basel).2022, 11(1):171.Korean Herb. Med. Inf. 2016, 4(1):35-42J Biochem Mol Toxicol....2020...Mol Pharmacol.2021, 99(2):163-174.Int J Med Sci.2021, 18(10):2155-2161.Biomed Chromatogr.2016, 30(10):1573-81LWT2020, 126:109313Molecules.2020, 25(18):4283.
Phytomedicine.2015, 22(14):1262-8Front Microbiol.2021, 12:736780.Food Chem.2020, 332:127412Natural Product Communications...2020...J Biochem Mol Toxicol....2021...J Anal Toxicol.2021, bkab015.Eur J Pharmacol.2021, 906:174220.Carbohydrate Polymer Technologies...2021...
Bull. Natl. Mus. Nat. Sci....2021...Food Chem.2017, 221:1135-1144Research on Crops.2017, 18(2)J. of The Korean Society of Food ...2017...J Ethnopharmacol.2022, 282:114574. Pharmacognosy Magazine...2018...Asian J Beauty Cosmetol...2021...
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Our products had been exported to the following research institutions and universities, And still growing.
Universidade da Beira Interior (Germany)Johannes Gutenberg University M... (Germany)University of Maryland School o... (USA)Northeast Normal University Cha... (China)
Weizmann Institute of Science (Israel)Universite Libre de Bruxelles (Belgium)University of Zurich (Switzerland)Monash University (Australia)
University Medical Center Mainz (Germany)University of Illinois (USA)University of Helsinki (Finland)
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6-Methoxywogonin
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manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
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Fax:
+86-27-84254680
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
J of Advanced Scientific R.2020, 11(3), p109-120.Food Chem.2018, 262:78-85J Agric Food Chem.2015, 63(44):9869-78Environ Toxicol.2019, 34(12):1354-1362J Med Food.2019, 22(10):1067-1077Chem Biol Interact.2018, 283:59-74Drug Dev Res.2020, doi: 10.1002Revista Brasileira de Farmacognosia2021, 31:794-804.TCI CO.2019, US20190151281A1JAOCS2021, 98(7):779-794.
Related Screening Libraries
| Size /Price /Stock |
10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
|
Related Libraries |
Flavonoids Compound Library |
| Description: |
6-Methoxywogonin shows weak anti-inflammatory effect. |
| In vitro: |
| Journal of Natural Medicines, 2013, 67(2):281-288. | | Quantitative analysis of anti-inflammatory activity of orengedokuto: Importance of combination of flavonoids in inhibition of PGE2 production in mouse macrophage-like cell line J774.1[Reference: WebLink] | Orengedokuto is a Kampo formula which has been used for removing "heat" and "poison" to treat inflammation, hypertension, gastrointestinal disorders, and liver and cerebrovascular diseases.
METHODS AND RESULTS:
In this report, we quantitatively analyzed the anti-inflammatory effect of the component crude drugs of orengedokuto and their constituents, using inhibition of prostaglandin E(2) (PGE(2)) production in the murine macrophage-like cell line J774.1. First, we compared PGE(2) production inhibitory activities of extracts of combinations of the component crude drugs, which showed that the activity could be ascribed to Scutellaria Root. Next, as baicalin (1), one of the major constituents of Scutellaria Root, did not show any activity, and baicalein (2), the aglycon of 1, showed only weak activity (IC(50) 92 μM), a hot-water extract of Scutellaria Root was fractionated under the guidance of the activity to give wogonin (3) (IC(50) 28 μM), 6-Methoxywogonin (4) (IC(50) 7.2 μM) and oroxylin A (5) (IC(50) 45 μM) from the most active fraction. However, the activities of these compounds at concentrations equivalent to those in the extract were weaker than that of the extract, and none of these compounds alone could explain the activity of the extract.
CONCLUSIONS:
Therefore, we examined the activity of combinations of compounds 2-5. Comparison of all combinations of the four compounds in a ratio which is the same as in the extract revealed that wogonin (3) had an essential role in the activity, and a combination of baicalein (2) and wogonin (3), together with 6-Methoxywogonin (4) or oroxylin A (5), was necessary to show activity equivalent to that of the extract. |
|
6-Methoxywogonin Description
| Source: |
The roots of Sophora flavescens Ait. |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
3.1817 mL |
15.9084 mL |
31.8167 mL |
63.6335 mL |
79.5418 mL |
| 5 mM |
0.6363 mL |
3.1817 mL |
6.3633 mL |
12.7267 mL |
15.9084 mL |
| 10 mM |
0.3182 mL |
1.5908 mL |
3.1817 mL |
6.3633 mL |
7.9542 mL |
| 50 mM |
0.0636 mL |
0.3182 mL |
0.6363 mL |
1.2727 mL |
1.5908 mL |
| 100 mM |
0.0318 mL |
0.1591 mL |
0.3182 mL |
0.6363 mL |
0.7954 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
