ChemFaces is a professional high-purity natural products manufacturer.
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2. Pharmacological research
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Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $8.9 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Food and Bioprocess Technology...2017...Journal of Functional Foods...2019...Appl. Sci. 2021, 11(22),10569Malaysian J of Fundamental and Ap...2018...Molecules.2020, 25(7):1625.Acta Chromatographica2021, 00960.Environ Toxicol.2020, doi: 10.1002J Ethnopharmacol.2017, 206:327-336
Sci Rep.2017, 7:46299Cell Physiol Biochem....2019...International Food Research Journ...2018...The Korea Journal of Herbology...2019...Environ Toxicol.2021, doi: 10.1002Metabolites.2019, 9(11):E271Oxid Med Cell Longev....2021...Front Microbiol.2021, 12:736780.
J Biol Chem.2014, 289(3):1723-31Food Engineering Progress...2019...BMC Complement Med Ther. ...2020...Appl. Sci. 2021, 11(1),14.ACS Chem Biol.2019, 14(5):873-881Asian Journal of Chemistry...2014...Toxicol Appl Pharmacol....2022...
Our products had been exported to the following research institutions and universities, And still growing.
Charles University in Prague (Czech Republic)University of Padjajaran (Indonesia)Universidad Veracuzana (Mexico)Cornell University (USA)
Research Unit Molecular Epigene... (Germany)Institute of Bioorganic Chemist... (Poland)Uniwersytet Jagielloński w Kra... (Poland)Institute of Chinese Materia Me... (China)
University of Canterbury (New Zealand)University of Maryland School o... (USA)Georgia Institute of Technology (USA)
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Molecules.2019, 24(19):E3417Front Pharmacol.2021, 12:652860. Antioxidants (Basel).2020, 9(2):E99Front Endocrinol (Lausanne).2020, 11:568436.Clin Transl Oncol.2019, 10.1007Front Pharmacol.2021, 12:690113.Anal Chim Acta.2018, 1039:162-171Phytomedicine.2019, 67:153159Biochem Pharmacol. 2020, 177:114014.J of the Korean Society of Cosmetics and Cosmetology2018, 399-406
Related Screening Libraries
|Size /Price /Stock
||10 mM * 100 uL in DMSO / Inquiry / In-stock |
10 mM * 1 mL in DMSO / Inquiry / In-stock
||Flavonoids Compound Library
||6-Methoxyflavone can be a potential candidate for the development of an effective immunomodulator via the suppression of NFAT-mediated T cell activation. The relative inactivity of 6-methoxyflavanone at α1β2 GABAA receptors and it's partial agonist action at ρ1W328 M GABA receptors suggest that it exhibits a unique profile not matched by other flavonoids.
||GABAA receptor | NFAT|
|Journal of Immunology, 2014, 193(6):2772. |
|6-Methoxyflavone inhibits NFAT translocation into the nucleus and suppresses T cell activation.[Pubmed: 25114106]|
|NFAT plays a crucial role in the immune system by regulating the transcription of inducible genes during immune responses. In T cells, NFAT proteins govern various cellular events related to T cell development, activation, tolerance induction, and differentiation. We previously reported the NFAT1-dependent enhancer activity of conserved noncoding sequence (CNS)-9, a distal cis-acting element, in the regulation of IL-10 transcription in T cells.
METHODS AND RESULTS:
In this study, we developed a T cell-based reporter system to identify compounds that modulate the regulatory activity of CNS-9. Among the identified candidates, 6-Methoxyflavone (6-MF) significantly inhibited the enhancer activity of CNS-9, thereby reducing IL-10 expression in T cells without affecting cell viability. 6-MF also downregulated the transcription of NFAT1 target genes such as IL-4, IL-13, and IFN-γ. Treatment of 6-MF inhibited the translocation of NFAT1 into the nucleus, which consequently interrupted NFAT1 binding to the target loci, without affecting the expression or dephosphorylation of NFAT1. Treatment of 6-MF to CD4(+) T cells or B cells isolated from mice with atopic dermatitis significantly reduced disease-associated cytokine production, as well as the levels of IgE. In addition, oral administration of 6-MF to atopic dermatitis mice ameliorated disease symptoms by reducing serum IgE levels and infiltrating lymphocytes.
Conclusively, our results suggest that 6-MF can be a potential candidate for the development of an effective immunomodulator via the suppression of NFAT-mediated T cell activation.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Neurochemical Research, 2014, 39(6):1068-1078. |
|Modulation of ionotropic GABA receptors by 6-methoxyflavanone and 6-methoxyflavone.[Pubmed: 24078264]|
METHODS AND RESULTS:
We evaluated the effects of 6-methoxyflavanone and 6-Methoxyflavone on wild-type α1/α2β2γ2L GABAA and ρ1 GABAC receptors and on mutant ρ1I307S, ρ1W328 M, ρ1I307S/W328 M GABAC receptors expressed in Xenopus oocytes using two-electrode voltage clamp and radioligand binding. 6-Methoxyflavanone and 6-Methoxyflavone act as a flumazenil-insensitive positive allosteric modulator of GABA responses at human recombinant α1β2γ2L and α2β2γ2L GABAA receptors. However, unlike 6-Methoxyflavone, 6-methoxyflavanone was relatively inactive at α1β2 GABAA receptors. 6-Methoxyflavanone inhibited [(3)H]-flunitrazepam binding to rat brain membranes. Both flavonoids were found to be inactive as modulators at ρ1, ρ1I307S and ρ1W328 M GABA receptors but acted as positive allosteric modulators of GABA at the benzodiazepine sensitive ρ1I307S/W328 M GABA receptors. This double mutant retains ρ1 properties of being insensitive to bicuculline and antagonised by TPMPA and THIP. Additionally, 6-methoxyflavanone was also a partial agonist at ρ1W328 M GABA receptors.
The relative inactivity of 6-methoxyflavanone at α1β2 GABAA receptors and it's partial agonist action at ρ1W328 M GABA receptors suggest that it exhibits a unique profile not matched by other flavonoids.