ChemFaces is a professional high-purity natural products manufacturer.
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2. Pharmacological research
Citing Use of our Products
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Exp Parasitol.2015, 153:160-4Analytical sci. & Tech2016, 186-193Nat Prod Commun.2017, 12(5):771-778Research on Crops.2017, 18(3):569Molecules.2017, 22(2)JPC-Journal of Planar Chromatogra...2017...Naunyn Schmiedebergs Arch Pharmac...2017...Plant Cell Tiss Org2017, 479-486
Pharmacognosy Magazine...2018...Phytother Res.2018, 32(12):2551-2559Korean Journal of Pharmacognosy...2018...J Nat Med.2018, 72(3):734-744Nat Commun.2019, 10(1):5169Evid Based Complement Alternat Me...2019...Molecules.2019, 24(23):E4303Toxicol Res.2019, 35(4):371-387
Int J Cosmet Sci.2019, 41(1):12-20J Funct Foods2019, 54:449-456Food Chem Toxicol.2020, 135:110863Antioxidants (Basel).2020, 9(2):E120Drug Chem Toxicol.2020, 1-12.Food Chem. 2020, 320:126530Rev. Chim.2020, 71(3),558-564
Our products had been exported to the following research institutions and universities, And still growing.
Donald Danforth Plant Science C... (USA)Centralised Purchases Unit (CPU... (India)Harvard University (USA)University of Auckland (New Zealand)
Worcester Polytechnic Institute (USA)University of Hull (United Kingdom)University of Virginia (USA)University of Zurich (Switzerland)
Sri Sai Aditya Institute of Pha... (India)University of the Basque Country (Spain)Washington State University (USA)
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
J Nat Prod.2017, 80(4):854-863Appl. Sci.2020, 10(23), 8729Chemistr of plant2016, 2016021195Int Immunopharmacol.2020, 90:107268.Anesth Pain Med (Seoul).2020, 15(4):478-485.Plant Archives2020, 2(1),2929-2934J Vet Sci.2020, 21(3):e39.Research J. Pharm. and Tech.2020, 13(7):3059-3064.Analytical Methods2018, 10(27)Arch Biochem Biophys.2020, 687:108363.
Related Screening Libraries
||7,3',4'-Trihydroxy-3-benzyl-2H-chromene is a potential xanthine oxidase inhibitor.|
|Chinese Journal of Pharmaceutical Analysis,2014,34(8):1391 -6. |
|In vitro screening of potential xanthine oxidase inhibitors by high-performance liquid chromatography[Reference: WebLink]|
|To develop an HPLC method for In vitro screening of xanthine oxidase inhibitors. |
METHODS AND RESULTS:
The activity of xanthine oxidase inhibitors was evaluated by the concentration of xanthine assayed by HPLC. The chromatographic conditions were as follows:column, Agilent SB-C18 (4.6 mm×250 mm, 5 μm); mobile phase, 0.02 mol·L-1 KH2PO4 (1% methanol); flow rate, 1.0 mL·min-1; detection wavelength, 254 nm; injection volume, 20 μL; column temperature, room temperature. Xanthine was perfectly separated from the other components under the selected chromatographic conditions. The xanthine oxidase inhibitory activity of 14 traditional Chinese medicines was evaluated by the above method. The 70% ethanol extracts of Quisqualis indica,Caesalpinia sappan,Polygonum cuspidatum and Paeonia suffruticosa showed significant activity with IC50 of 10. 04,8. 02,2. 06 and 1. 36 mg·mL- 1,respectively. Then,24 compounds isolated from C. sappan were evaluated by the above method. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene,3-deoxysappanone B,sappanchalcone and protosappanin A showed xanthine oxidase inhibitory activity.
This HPLC method is simple,accurate and suitable for in vitro screening of xanthine oxidase inhibitors.
||The heartwoods of Caesalpinia sappan L.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|J Nat Med. 2008 Jul;62(3):325-7. |
|A new homoisoflavan from Caesalpinia sappan.[Pubmed: 18404306]|
METHODS AND RESULTS:
A new homoisoflavan, 7,3',4'-Trihydroxy-3-benzyl-2H-chromene (1), was isolated from the dried heartwood of Caesalpinia sappan L., together with seven known phenolic compounds. The structure of the new compound (1) was determined on the basis of spectroscopic analysis.