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    Natural Products
    7,3',4'-Trihydroxy-3-benzyl-2H-chromene
    Information
    CAS No. 1111897-60-9 Price
    Catalog No.CFN99209Purity>=98%
    Molecular Weight270.3 Type of CompoundFlavonoids
    FormulaC16H14O4Physical DescriptionPowder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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    7,3',4'-Trihydroxy-3-benzyl-2H-chromene

    7,3',4'-Trihydroxy-3-benzyl-2H-chromene
    Product Name 7,3',4'-Trihydroxy-3-benzyl-2H-chromene
    CAS No.: 1111897-60-9
    Catalog No.: CFN99209
    Molecular Formula: C16H14O4
    Molecular Weight: 270.3 g/mol
    Purity: >=98%
    Type of Compound: Flavonoids
    Physical Desc.: Powder
    Targets: XO
    Source: The heartwoods of Caesalpinia sappan L.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Inhibitors Compound Library
  • Flavonoids Compound Library
  • Biological Activity
    Description: 7,3',4'-Trihydroxy-3-benzyl-2H-chromene is a potential xanthine oxidase inhibitor.
    Targets: XO
    In vitro:
    Chinese Journal of Pharmaceutical Analysis,2014,34(8):1391 -6.
    In vitro screening of potential xanthine oxidase inhibitors by high-performance liquid chromatography[Reference: WebLink]
    To develop an HPLC method for In vitro screening of xanthine oxidase inhibitors.
    METHODS AND RESULTS:
    The activity of xanthine oxidase inhibitors was evaluated by the concentration of xanthine assayed by HPLC. The chromatographic conditions were as follows:column, Agilent SB-C18 (4.6 mm×250 mm, 5 μm); mobile phase, 0.02 mol·L-1 KH2PO4 (1% methanol); flow rate, 1.0 mL·min-1; detection wavelength, 254 nm; injection volume, 20 μL; column temperature, room temperature. Xanthine was perfectly separated from the other components under the selected chromatographic conditions. The xanthine oxidase inhibitory activity of 14 traditional Chinese medicines was evaluated by the above method. The 70% ethanol extracts of Quisqualis indica,Caesalpinia sappan,Polygonum cuspidatum and Paeonia suffruticosa showed significant activity with IC50 of 10. 04,8. 02,2. 06 and 1. 36 mg·mL- 1,respectively. Then,24 compounds isolated from C. sappan were evaluated by the above method. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene,3-deoxysappanone B,sappanchalcone and protosappanin A showed xanthine oxidase inhibitory activity.
    CONCLUSIONS:
    This HPLC method is simple,accurate and suitable for in vitro screening of xanthine oxidase inhibitors.
    7,3',4'-Trihydroxy-3-benzyl-2H-chromene Description
    Source: The heartwoods of Caesalpinia sappan L.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.6996 mL 18.498 mL 36.9959 mL 73.9919 mL 92.4898 mL
    5 mM 0.7399 mL 3.6996 mL 7.3992 mL 14.7984 mL 18.498 mL
    10 mM 0.37 mL 1.8498 mL 3.6996 mL 7.3992 mL 9.249 mL
    50 mM 0.074 mL 0.37 mL 0.7399 mL 1.4798 mL 1.8498 mL
    100 mM 0.037 mL 0.185 mL 0.37 mL 0.7399 mL 0.9249 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    J Nat Med. 2008 Jul;62(3):325-7.
    A new homoisoflavan from Caesalpinia sappan.[Pubmed: 18404306]

    METHODS AND RESULTS:
    A new homoisoflavan, 7,3',4'-Trihydroxy-3-benzyl-2H-chromene (1), was isolated from the dried heartwood of Caesalpinia sappan L., together with seven known phenolic compounds. The structure of the new compound (1) was determined on the basis of spectroscopic analysis.
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