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9-O-Feruloyl-5,5'-dimethoxylariciresinol
9-O-Feruloyl-5,5'-dimethoxylariciresinol
Information
CAS No. 166322-14-1 Price
Catalog No.CFN99700Purity>=98%
Molecular Weight596.6 Type of CompoundLignans
FormulaC32H36O11Physical DescriptionPowder
Download COA    MSDS    SDF    ManualSimilar structuralComparison (Web)  (SDF)
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    9-O-Feruloyl-5,5'-dimethoxylariciresinol

    9-O-Feruloyl-5,5'-dimethoxylariciresinol
    Product Name 9-O-Feruloyl-5,5'-dimethoxylariciresinol
    CAS No.: 166322-14-1
    Catalog No.: CFN99700
    Molecular Formula: C32H36O11
    Molecular Weight: 596.6 g/mol
    Purity: >=98%
    Type of Compound: Lignans
    Physical Desc.: Powder
    Targets: TNF-伪 | IL Receptor
    Source: The herbs of Viburnum cylindricum
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price:
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    product package
  • Drug Des Devel Ther.2020, 14:5189-5204.
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
    Biological Activity
    Description: (+)-9'-O-trans-feruloyl-5,5'-dimethoxylariciresinol may have anti-allergic inflammatory effect, it can inhibit release of histamine from mast cells. It shows cytotoxicity against a small panel of human tumor cell lines, with ED50 values of 9.86 to approximately 12.68 microg/ml.
    Targets: TNF-α | IL Receptor
    In vitro:
    Arch. Pharm. Res.,2014 Apr;37(4):467-72.
    A new neolignan and lignans from the stems of Lindera obtusiloba Blume and their anti-allergic inflammatory effects.[Pubmed: 24014307 ]

    METHODS AND RESULTS:
    A new neolignan, linderin A (1), together with six known lignans, (+)-xanthoxyol (2), pluviatilol (3), actiforin (4), (+)-syringaresinol (5), (+)-(7S,8R,8'R)-acuminatolide (6), and (+)-9'-O-trans-feruloyl-5,5'-dimethoxylariciresinol (9-O-Feruloyl-5,5'-dimethoxylariciresinol,7) were isolated from the stems of Lindera obtusiloba Blume (Lauraceae). Their chemical structures were elucidated by a combination of spectroscopic analysis and chemical reaction, and the absolute configuration of 1 was determined by Mosher's esterification. The effect of compounds 1-7 on tumor necrosis factor (TNF)-α, interleukin(IL)-6, and their inhibitory activity of histamine release were examined using human mast cells. Among the lignans tested, compounds 1, 3, 4, 6, and 7 inhibited release of histamine from mast cells. Especially, compounds 1 and 4 suppressed the gene expressions of pro-inflammatory cytokines, TNF-α, and IL-6 in human mast cells.
    CONCLUSIONS:
    Our findings suggest that the lignan constituents in L. obtusiloba may contribute to its anti-allergic inflammatory effects.
    9-O-Feruloyl-5,5'-dimethoxylariciresinol Description
    Source: The herbs of Viburnum cylindricum
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6762 mL 8.3808 mL 16.7616 mL 33.5233 mL 41.9041 mL
    5 mM 0.3352 mL 1.6762 mL 3.3523 mL 6.7047 mL 8.3808 mL
    10 mM 0.1676 mL 0.8381 mL 1.6762 mL 3.3523 mL 4.1904 mL
    50 mM 0.0335 mL 0.1676 mL 0.3352 mL 0.6705 mL 0.8381 mL
    100 mM 0.0168 mL 0.0838 mL 0.1676 mL 0.3352 mL 0.419 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Arch Pharm Res. 1999 Aug;22(4):417-22.
    Two new lignans from Lindera obtusiloba blume.[Pubmed: 10489885]

    METHODS AND RESULTS:
    Two new furanolignans (3, 5), together with three known lignans (1, 2, 4), were isolated from the stem of Lindera obtusiloba (Lauraceae). The structures of the compounds were determined as actifolin (1), pluviatilol (2), 5,6-dihydroxymatairesinol (3), (+)-syringaresinol (4), and (+)-9'-O-trans-feruloyl-5,5'-dimethoxylariciresinol (9-O-Feruloyl-5,5'-dimethoxylariciresinol,5) on the basis of physicochemical and spectroscopic evidences.
    CONCLUSIONS:
    Compounds 1, 2, 3, and 5 showed cytotoxicity against a small panel of human tumor cell lines with ED50 values of 3.40 to approximately 19.27 microg/ml.
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