Acetamide | CAS:60-35-5 | Manufacturer ChemFaces

Acetamide

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Description:

Acetamide (2.88 g/kg/d) can reduce central nervous lesions, but the efficacy is not improved after increasing the dose.

Targets:

Histone Methyltransferase

In vivo:

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2014 Jun;32(6):438-41.

Effects of acetamide at different doses on expression of amino acids in cerebral cortex of rats with acute tetramine poisoning.[Pubmed: 25169228]

To investigate the effects of Acetamide at different doses on the expression of inhibitory amino acids (gamma-aminobutyric acid, GABA) and excitatory amino acid (glutamate, Glu) in the cerebral cortex of rats with acute tetramine (TET) poisoning.
METHODS AND RESULTS:
Eighty Sprague-Dawley rats (SPF) were randomly divided into five groups, with 16 rats in each group: saline control group, dimethyl sulfoxide (DMSO) control group, TET exposure group, high-dose (2.8 g/kg/d) Acetamide treatment group, and super-high-dose (5.6 g/kg/d) Acetamide treatment group. Rats in the exposure group and treatment groups were exposed to TET by intragastric administration after fasting, and were then intramuscularly injected with saline or different doses of Acetamide in the following 5 days.The changes in the high-dose Acetamide treatment group were similar to those in the TET exposure group, but became more like those in the control groups after 48 h; the OD value in super-high-dose Acetamide treatment group was significantly higher than that in the TET exposure group at 3 h after treatment (P < 0.01), while no significant difference was found at 12 h; it was significantly lower than those of all other groups at 48 h and 7 d (P < 0.01).
CONCLUSIONS:
Treatment with high dose of Acetamide has some curative effect on TET poisoning-induced central nervous lesion, while the effect of super-high-dose Acetamide on expression of neurotransmitters is too complex to evaluate.

Acetamide Description

Source:	The herbs of Viola yedonensis Makino
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Animal Research:

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2014 Apr;32(4):289-92.

Effect of acetamide on histopathology in cerebral cortex of rats with tetramine poisoning.[Pubmed: 24754949]

To observe the effect of different doses of Acetamide on the histopathology in the cerebral cortex of rats with tetramine (TET) poisoning and to provide a basis for the treatment of fluoroAcetamide poisoning with Acetamide.
METHODS AND RESULTS:
Eighty clean Sprague-Dawley rats were randomly divided into five groups: saline control group,dimethylsulfoxide water solution control group,TET poisoning group, Acetamide (2.88 g/kg/d) treatment group, and Acetamide (5.68 g/kg/d) treatment group, with 16 rats in each group. The light microscopy showed that the TET poisoning group had hypoxia changes in the cerebral cortex, which worsened over time; the treatment groups had reduced hypoxia changes, and the Acetamide (2.88 g/kg/d) treatment group had more reduction than the Acetamide (5.68 g/kg/d) treatment group. The electron microscopy showed that the apoptosis of neuronal cells were the main pathological changes in the TET poisoning group; the treatment groups had reduced apoptotic changes, and the Acetamide (2.88 g/kg/d) treatment group had more reduction than the Acetamide (5.68 g/kg/d) treatment group.
CONCLUSIONS:
No pathological changes associated with the synergistic toxic effect of Acetamide and TET are found in the cerebral cortex. Acetamide (2.88 g/kg/d) could reduce central nervous lesions, but the efficacy is not improved after increasing the dose. For patients who cannot be identified with TET or fluoroAcetamide poisoning, Acetamide could be considered for treatment.

Product Name	Acetamide
Price:	$30 / 20mg
CAS No.:	60-35-5
Catalog No.:	CFN97025
Molecular Formula:	C₂H₅NO
Molecular Weight:	59.1 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Cryst.
Source:	The herbs of Viola yedonensis Makino
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Neuroprotection Compound Library Alkaloids Compound Library Histone Methyltransferase Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	16.9205 mL	84.6024 mL	169.2047 mL	338.4095 mL	423.0118 mL
5 mM	3.3841 mL	16.9205 mL	33.8409 mL	67.6819 mL	84.6024 mL
10 mM	1.692 mL	8.4602 mL	16.9205 mL	33.8409 mL	42.3012 mL
50 mM	0.3384 mL	1.692 mL	3.3841 mL	6.7682 mL	8.4602 mL
100 mM	0.1692 mL	0.846 mL	1.692 mL	3.3841 mL	4.2301 mL

CFN00075	Ethylamine	75-04-7	45.08	C₂H₇N
CFN00077	1-Heptylamine	111-68-2	115.22	C₇H₁₇N
CFN00087	3-Methyl-1-butylamine	107-85-7	87.16	C₅H₁₃N
CFN00091	Propylamine	107-10-8	59.11	C₃H₉N
CFN90077	DL-Homocysteic acid	504-33-6	183.18	C₄H₉NO₅S
CFN90429	L-Theanine	3081-61-6	174.19	C₇H₁₄N₂O₃
CFN90550	L-Arginine	74-79-3	174.20	C₆H₁₄N₄O₂
CFN90551	L-Citruline	372-75-8	175.18	C₆H₁₃N₃O₃
CFN97025	Acetamide	60-35-5	59.1	C₂H₅NO