Science | Nature | Cell | View More
Natural Products
Adavosertib (MK-1775)
Adavosertib (MK-1775)
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Adavosertib (MK-1775)
Price:
CAS No.: 955365-80-7
Catalog No.: CFN60066
Molecular Formula: C27H32N8O2
Molecular Weight: 500.6 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source:
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Kamphaengphet Rajabhat University (Thailand)
  • Universidad de Antioquia (Colombia)
  • Complutense University of Madrid (Spain)
  • Mendel University in Brno (Czech Republic)
  • Rio de Janeiro State University (Brazil)
  • University of Toronto (Canada)
  • Kyoto University (Japan)
  • Institute of Tropical Disease U... (Indonesia)
  • University of Bonn (Germany)
  • Sapienza University of Rome (Italy)
  • Chungnam National University (Korea)
  • More...
Package
Featured Products
Procyanidin A2

Catalog No: CFN96491
CAS No: 41743-41-3
Price: $238/10mg
Cordycepin

Catalog No: CFN98566
CAS No: 73-03-0
Price: $40/20mg
Ginsenoside Re

Catalog No: CFN99974
CAS No: 52286-59-6
Price: $40/20mg
Procyanidin A1

Catalog No: CFN96495
CAS No: 103883-03-0
Price: $288/20mg
Bavachin

Catalog No: CFN98007
CAS No: 19879-32-4
Price: $40/20mg
Angoroside C

Catalog No: CFN98149
CAS No: 115909-22-3
Price: $98/20mg
Cepharanthine

Catalog No: CFN98570
CAS No: 481-49-2
Price: $40/20mg
ar-Turmerone

Catalog No: CFN89231
CAS No: 532-65-0
Price: $238/20mg
Phytic acid

Catalog No: CFN99792
CAS No: 83-86-3
Price: $40/20mg
Alisol B 23-acetate

Catalog No: CFN99753
CAS No: 26575-95-1
Price: $50/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Adavosertib (MK-1775, AZD1775) is a potent and selective Wee1 inhibitor with IC50 of 5.2 nM in a cell-free assay; hinders G2 DNA damage checkpoint.
Targets: Wee1
Adavosertib (MK-1775) Description
Source:
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Isorhamnetin 3,5-O-diglucoside

Catalog No: CFN95488
CAS No: 2035413-03-5
Price: $318/5mg
3,7,25-Trihydroxycucurbita-5,23-di...

Catalog No: CFN95150
CAS No: 85372-65-2
Price: $318/5mg
Kaempferol 3,4'-di-O-glucoside

Catalog No: CFN95357
CAS No: 71939-16-7
Price: $318/5mg
3-O-[5'''-O-feruloyl-beta-D-apiofu...

Catalog No: CFN95154
CAS No: 148210-00-8
Price: $413/5mg
Cassiaside C

Catalog No: CFN95120
CAS No: 119170-52-4
Price: $318/10mg
Bruceantinol B

Catalog No: CFN95216
CAS No: 1822332-33-1
Price: $318/5mg
Gypenoside XIII

Catalog No: CFN95239
CAS No: 80325-22-0
Price: $288/10mg
(-)-Epiafzelechin 3-O-gallate

Catalog No: CFN95081
CAS No: 108907-43-3
Price: $388/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.9976 mL 9.988 mL 19.976 mL 39.9521 mL 49.9401 mL
5 mM 0.3995 mL 1.9976 mL 3.9952 mL 7.9904 mL 9.988 mL
10 mM 0.1998 mL 0.9988 mL 1.9976 mL 3.9952 mL 4.994 mL
50 mM 0.04 mL 0.1998 mL 0.3995 mL 0.799 mL 0.9988 mL
100 mM 0.02 mL 0.0999 mL 0.1998 mL 0.3995 mL 0.4994 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Animal Research:
Mol Cancer Ther,2009 Nov;8(11):2992-3000.
Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents.[Pubmed: 19887545]
Animal Models:Immunodeficient nude rats (F344/NJcl-rnu) bearing WiDr, HeLa-luc, or TOV21G-shp53 tumors
Dosages: ~20 mg/kg/day
Administration: Orally
Procyanidin A2

Catalog No: CFN96491
CAS No: 41743-41-3
Price: $238/10mg
Cordycepin

Catalog No: CFN98566
CAS No: 73-03-0
Price: $40/20mg
Ginsenoside Re

Catalog No: CFN99974
CAS No: 52286-59-6
Price: $40/20mg
Procyanidin A1

Catalog No: CFN96495
CAS No: 103883-03-0
Price: $288/20mg
Bavachin

Catalog No: CFN98007
CAS No: 19879-32-4
Price: $40/20mg
Angoroside C

Catalog No: CFN98149
CAS No: 115909-22-3
Price: $98/20mg
Cepharanthine

Catalog No: CFN98570
CAS No: 481-49-2
Price: $40/20mg
ar-Turmerone

Catalog No: CFN89231
CAS No: 532-65-0
Price: $238/20mg
Phytic acid

Catalog No: CFN99792
CAS No: 83-86-3
Price: $40/20mg
Alisol B 23-acetate

Catalog No: CFN99753
CAS No: 26575-95-1
Price: $50/20mg
Tags: buy Adavosertib (MK-1775) | Adavosertib (MK-1775) supplier | purchase Adavosertib (MK-1775) | Adavosertib (MK-1775) cost | Adavosertib (MK-1775) manufacturer | order Adavosertib (MK-1775) | Adavosertib (MK-1775) distributor
ody>