Diarylcomosol III | CAS:1452487-93-2 | Manufacturer ChemFaces

Diarylcomosol III

ChemFaces products have been cited in many studies from excellent and top scientific journals

Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC

How to Order

Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com

Delivery time

Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal

Citing Use of our Products

More Impact Factor than five Cite...

* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.

According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

Featured Products

More...

Apigenin

Catalog No: CFN98843
CAS No: 520-36-5
Price: $40/20mg

Rosmarinyl glucoside

Catalog No: CFN95297
CAS No: 910028-78-3
Price: $413/5mg

Aerugidiol

Catalog No: CFN92621
CAS No: 116425-35-5
Price: $318/5mg

Meloside A

Catalog No: CFN90132
CAS No: 60767-80-8
Price: $238/5mg

Ergosterol

Catalog No: CFN98980
CAS No: 57-87-4
Price: $30/20mg

9-Hydroxycanthin-6-one

Catalog No: CFN92126
CAS No: 138544-91-9
Price: $ / mg

Lasiocarpine

Catalog No: CFN00289
CAS No: 303-34-4
Price: $ /

Caftaric acid

Catalog No: CFN00384
CAS No: 67879-58-7
Price: $138/20mg

Eburicol

Catalog No: CFN97175
CAS No: 6890-88-6
Price: $ /

6',7'-Dihydroxybergamottin

Catalog No: CFN98307
CAS No: 264234-05-1
Price: $318/10mg

Description:

Diarylcomosol III shows inhibitory effects on melanogenesis in B16 melanoma cells, it is a promising therapeutic agent for the treatment of skin disorders.

In vitro:

Bioorg Med Chem Lett. 2013 Sep 15;23(18):5178-81

Diarylheptanoids with inhibitory effects on melanogenesis from the rhizomes of Curcuma comosa in B16 melanoma cells.[Pubmed: 23910596 ]

The methanolic extract from the dried rhizomes of Curcuma comosa cultivated in Thailand was found to inhibit melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells.
METHODS AND RESULTS:
From the methanolic extract, three new diarylheptanoids, diarylcomosol I, diarylcomosolⅡ, Diarylcomosol III, were isolated together with 12 known diarylheptanoids. Their chemical structures were elucidated on the basis of chemical and physicochemical evidence. The diarylheptanoids inhibited melanogenesis, and several structural requirements of the active constituents for the inhibition were clarified. In particular, (3R)-1,7-bis(4-hydroxyphenyl)-(6E)-6-hepten-3-ol exhibited stronger inhibitory effect [IC50=0.36 μM] without inducing cytotoxicity. The biological effect was much stronger than that of a reference compound, arbutin [IC50=174 μM].
CONCLUSIONS:
We conclude that diarylheptanoid analogs are promising therapeutic agents for the treatment of skin disorders.

Diarylcomosol III Description

Source:	The dried rhizomes of Curcuma comosa.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Diarylcomosol III
Price:
CAS No.:	1452487-93-2
Catalog No.:	CFN96895
Molecular Formula:	C₂₁H₂₈O₆
Molecular Weight:	376.44 g/mol
Purity:	>=98%
Type of Compound:	Phenols
Physical Desc.:	Oil
Source:	The dried rhizomes of Curcuma comosa.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-melanogenic Compound Library Phenols Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.6565 mL	13.2823 mL	26.5647 mL	53.1293 mL	66.4116 mL
5 mM	0.5313 mL	2.6565 mL	5.3129 mL	10.6259 mL	13.2823 mL
10 mM	0.2656 mL	1.3282 mL	2.6565 mL	5.3129 mL	6.6412 mL
50 mM	0.0531 mL	0.2656 mL	0.5313 mL	1.0626 mL	1.3282 mL
100 mM	0.0266 mL	0.1328 mL	0.2656 mL	0.5313 mL	0.6641 mL

CFN60359	TWS119	601514-19-6	318.33	C₁₈H₁₄N₄O₂
CFN70259	Rebaudioside M	1220616-44-3	1291.3	C₅₆H₉₀O₃₃
CFN92967	Paprazine	36417-86-4	283.32	C₁₇H₁₇NO₃
CFN92044	Petunidin-3-O-arabinoside chloride	28500-03-0	484.8	C₂₁H₂₁ClO₁₁