ChemFaces is a professional high-purity natural products manufacturer.
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Arch Pharm Res.2015, 38(6):1080-9Acta Physiologiae Plantarum2016, 38:7Korean J of Food Science&Technolo...2017...Appl Microbiol Biotechnol....2018...Korean J of Medicinal Crop Scienc...2018...Molecules.2018, 23(3):E615Asian Journal of Chemistry...2018...Korean J Environ Agric....2018...
Int J Biol Macromol.2019, 126:653-661J Pharm Biomed Anal.2019, 172:268-277Molecules.2019, 24(4):E709Cell Physiol Biochem....2019...Phytomedicine.2019, 67:153159J Clin Med.2019, 8(10):E1664Nutrients.2020, 12(11):3448. J Ethnopharmacol.2020, 260:112988.
J Ginseng Res.2020, 44(4):611-618.Eur Endod J.2020, 5(1):23-27.Horticulture Research2020, 7:111. Int Immunopharmacol.2020, 90:107268.Environ Toxicol.2020, doi: 10.1002Nutraceutical Research . ...2021...Naunyn Schmiedebergs Arch Pharmac...2021...
Our products had been exported to the following research institutions and universities, And still growing.
Auburn University (USA)Kazusa DNA Research Institute (Japan)University of Indonesia (Indonesia)Universitas Airlangga (Indonesia)
Heidelberg University (Germany)VIB Department of Plant Systems... (Belgium)Chungnam National University (Korea)Korea Intitute of Science and T... (Korea)
Cancer Research Initatives Foun... (Malaysia)University of Eastern Finland (Finland)Martin Luther University of Hal... (Germany)
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Biomed Chromatogr.2016, 30(10):1573-81Nature Ecology & Evolution2020, doi: 10.1038Molecules.2019, 24(17):E3127J Mol Recognit.2020, 33(2):e2819J Biomed Sci.2020, 27(1):60.Molecules.2019, 24(10):E1926Sci Rep.2018, 8:9267Sci Rep. 2018, 462(8)Nutrients.2020, 12(5):1242.Food and Bioprocess Technology2017, 10(6):1074-1092
Related Screening Libraries
|Size /Price /Stock
||10 mM * 100 uL in DMSO / Inquiry / In-stock |
10 mM * 1 mL in DMSO / Inquiry / In-stock
||Flavonoids Compound Library
|| Genistein 7-O-glucuronide has estrogenic potency.|
|Toxicology in Vitro, 2015,29(4):706-715. |
|Deconjugation of soy isoflavone glucuronides needed for estrogenic activity.[Reference: WebLink]|
|Soy isoflavones (SIF) are present in the systemic circulation as conjugated forms of which the estrogenic potency is not yet clear.
METHODS AND RESULTS:
The present study provides evidence that the major SIF glucuronide metabolites in blood, genistein-7-O-glucuronide (GG) and Genistein 7-O-glucuronide (DG), only become estrogenic after deconjugation. The estrogenic potencies of genistein (Ge), daidzein (Da), GG and DG were determined using stably transfected U2OS-ERα, U2OS-ERβ reporter gene cells and proliferation was tested in T47D-ERβ cells mimicking the ERα/ERβ ratio of healthy breast cells and inT47D breast cancer cells. In all assays applied, the estrogenic potency of the aglycones was significantly higher than that of their corresponding glucuronides. UPLC analysis revealed that in U2OS and T47D cells, 0.2–1.6% of the glucuronides were deconjugated to their corresponding aglycones. The resulting aglycone concentrations can account for the estrogenicity observed upon glucuronide exposure. Interestingly, under similar experimental conditions, rat breast tissue S9 fraction was about 30 times more potent in deconjugating these glucuronides than human breast tissue S9 fraction.
Our study confirms that SIF glucuronides are not estrogenic as such, and that the small % of deconjugation in the cell is enough to explain the slight bioactivity observed for the SIF-glucuronides. Species differences in deconjugation capacity should be taken into account when basing risk–benefit assessment of these SIF for the human population on animal data.
Genistein 7-O-glucuronide Description
||The seeds of Glycine max
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.