ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
Citing Use of our Products
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $152.6 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Korean J. of Food Sci. and Tech...2016...Chemistry of Plant Materials....2016...Semyung University2017, 149407Asian Journal of Chemistry...2018...J Herbmed Pharmacol.2018, 7(4):280-286Nat Commun.2019, 10(1):2745Nutrients.2019, 11(11):E2694J Adv Res.2019, 17:85-94
Molecules.2019, 24(12):E2286Molecules.2019, 24(22):E4022Phytother Res.2019, 33(7):1784-1793Cell Physiol Biochem....2019...J Clin Med.2019, 8(10):E1664Biomedicine & Pharmacotherapy...2020...Molecules.2020, 25(3):734Metabolites.2020, 10(12):497.
Appl. Sci.2020, 10(20), 7323.Pharmacognosy Journal....2020...Drug Des Devel Ther.2020, 14:969-976.Int J Mol Sci.2020, 21(19),7070.Bioorg Med Chem.2020, 28(12):115553.Antioxidants (Basel).2020, 9(11):1121.Natural Product Communications...2020...
Our products had been exported to the following research institutions and universities, And still growing.
University of South Australia (Australia)Instituto Politécnico de Bragan?a (Portugal)Weizmann Institute of Science (Israel)University of Mysore (India)
Universidad Miguel Hernández (Spain)Periyar University (India)Ain Shams University (Egypt)Universidad Veracuzana (Mexico)
University of Canterbury (New Zealand)Ateneo de Manila University (Philippines)University of Leipzig (Germany)
Related Screening Libraries
||Gnetol significantly suppresses melanin biosynthesis in murine B16 melanoma cells, it has a strong inhibitory effect on murine tyrosinase activity. Gnetol is active in the inhibition of arachidonic acid (AA)-induced platelet aggregation.Gnetol has the IC(50) value of 1.3 uM towards butyrylcholinesterase and shows a reversible and competitive inhibition in the kinetic study.
||Tyrosinase | BACE|
|Biosci Biotechnol Biochem. 2003 Mar;67(3):663-5. |
|Gnetol as a potent tyrosinase inhibitor from genus Gnetum.[Pubmed: 12723623]|
|Gnetol (2,3',5',6-tetrahydroxy-trans-stilbene), a naturally occurring compound particularly found in the genus Gnetum, had a strong inhibitory effect on murine tyrosinase activity.|
METHODS AND RESULTS:
Gnetol (IC50, 4.5 microM) was stronger than kojic acid (IC50, 139 microM) as a standard inhibitor for murine tyrosinase activity. Moreover, Gnetol significantly suppressed, melanin biosynthesis in murine B16 melanoma cells.
|Phytother Res. 2012 Oct;26(10):1564-8. |
|Stilbenoids from Gnetum macrostachyum attenuate human platelet aggregation and adhesion.[Pubmed: 22511550 ]|
|Platelets play a critical role in pathogenesis of cardiovascular disorders and strokes. The inhibition of platelet function is beneficial for the treatment and prevention of these diseases.
The phytochemical investigation of stilbenoids from Gnetum macrostachyum Hook. f. led to the isolation of trans-resveratrol (1), isorhapotigenin (2), Gnetol (3), bisisorhapontigenin B (4), gnetin C (5), parvifolol A (6), latifolol (7) and gnetuhainin C (8).
METHODS AND RESULTS:
The isolated stilbenoids were evaluated for in vitro antiplatelet activities via agonist-induced platelet aggregation and static platelet-collagen adhesion assays using washed human platelets. Compounds 1, 2 and 3 were active in the inhibition of arachidonic acid (AA)-induced platelet aggregation. Compound 2 and its dimer, compound 4, were the most active stilbenoids in thrombin-induced platelet aggregation. Moreover, compounds 4, 5 and 6, tended to be more potent than monomeric and trimeric stilbenoids in a human platelet-collagen adhesion assay under static conditions.
This is the first report of the antiplatelet activity of stilbenoids isolated from G. macrostachyum.
||The herbs of Gnetum cleistostachynm
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Fitoterapia. 2012 Jun;83(4):780-4. |
|Potent and selective butyrylcholinesterase inhibitors from Ficus foveolata.[Pubmed: 22450264 ]|
METHODS AND RESULTS:
Four stilbenes (1-4), one inseparable mixture of two alkyl diferulates (5a, 5b), one alkyl ferulate (6) and four flavonoids (7-10) were isolated from Ficus foveolata Wall.
Except for quercetin (10), the other ten constituents were isolated from F. foveolata for the first time. In addition, one of the two components in mixture 5 is a new compound identified as (1E,22E)-1,22-docosanediol diferulate (5a). All nine isolated compounds, plus the mixture of 5a and 5b known as 5, exhibited a low or no activity against acetylcholinesterase. However, and interestingly, the stilbenes 1-4 showed a high inhibition towards butyrylcholinesterase.
Gnetol (4) had the lowest IC(50) value of 1.3μM towards butyrylcholinesterase and showed a reversible and competitive inhibition in the kinetic study.