Science | Nature | Cell | View More
Natural Products
Guaiacin
Guaiacin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Guaiacin
Price: $338 / 5mg
CAS No.: 36531-08-5
Catalog No.: CFN97039
Molecular Formula: C20H24O4
Molecular Weight: 328.4 g/mol
Purity: >=98%
Type of Compound: Lignans
Physical Desc.: Powder
Source: The Leaves of Guaiacum officinale.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $227.8 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • University of Wollongong (Australia)
  • National Cancer Center Research... (Japan)
  • Uniwersytet Gdański (Poland)
  • Universidade Católica Portuguesa (Portugal)
  • Research Unit Molecular Epigene... (Germany)
  • University of Indonesia (Indonesia)
  • Kyung Hee University (Korea)
  • Guangzhou Institutes of Biomedi... (China)
  • University of the Basque Country (Spain)
  • Universidade Federal de Pernamb... (Brazil)
  • University of Maryland School o... (USA)
  • More...
Package
Featured Products
Cryptotanshinone

Catalog No: CFN98478
CAS No: 35825-57-1
Price: $30/20mg
Ganoderic acid F

Catalog No: CFN92055
CAS No: 98665-15-7
Price: $318/20mg
Kaempferol 3-O-beta-sophoroside

Catalog No: CFN92372
CAS No: 19895-95-5
Price: $268/20mg
3-oxo-Olean-12-en-28-oic acid

Catalog No: CFN92194
CAS No: 17990-42-0
Price: $90/20mg
Obtusifolin

Catalog No: CFN90394
CAS No: 477-85-0
Price: $268/20mg
Intermedine N-oxide

Catalog No: CFN00459
CAS No: 95462-14-9
Price: $ / mg
Betaine

Catalog No: CFN99546
CAS No: 107-43-7
Price: $30/20mg
Sugiol

Catalog No: CFN92187
CAS No: 511-05-7
Price: $ / mg
Cyclo(Pro-Leu)

Catalog No: CFN90281
CAS No: 5654-86-4
Price: $238/10mg
Notoginsenoside R1

Catalog No: CFN99999
CAS No: 80418-24-2
Price: $50/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: (+)-Guaiacin has significant neuroprotective, and anti-inflammatory activities, it can inhibit cyclooxygenase (COX)-1 and COX-2. (+)-Guaiacin shows potent in vitro activities against the release of beta-glucuronidase in rat polymorphonuclear leukocytes (PMNs) induced by platelet-activating factor (PAF), with 42.5-75.6% inhibition at 10(-5) M.
Targets: PAFR | COX
In vitro:
Chem Biodivers. 2015 Jul;12(7):1057-67.
Biological Evaluation of Secondary Metabolites from the Root of Machilus obovatifolia.[Pubmed: 26172326]
Bioassay-guided fractionation of the root of Machilus obovatifolia led to the isolation of four new lignans, epihenricine B (1), threo-(7'R,8'R) and threo-(7'S,8'S)-methylmachilusol D (2 and 3), and isofragransol A (4), along with 23 known compounds.
METHODS AND RESULTS:
The compounds were obtained as isomeric mixtures (i.e., 2/3 and 4/20, resp.). The structures were elucidated by spectral analyses. Among the isolates, 1, licarin A (12), Guaiacin (14), (±)-syringaresinol (21), and (-)-epicatechin (23) showed ABTS (=2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) cation radical-scavenging activity, with SC50 values of 11.7±0.5, 12.3±1.1, 11.0±0.1, 10.6±0.3, and 9.5±0.2 μM in 20 min, respectively. In addition, kachirachirol B (17) showed cytotoxicity against the NCI-H460 cell line with an IC50 value of 3.1 μg/ml.
Biol Pharm Bull. 2007 Apr;30(4):814-7.
Stimulatory activity of lignans from Machilus thunbergii on osteoblast differentiation.[Pubmed: 17409528]
Phytoestrogens are naturally occurring compounds exerting estrogenic activity, and include isoflavonoids, flavonoids and lignans.
METHODS AND RESULTS:
In the present study, we evaluated the stimulating activity of six lignans, meso-dihydroguaiaretic acid, nordihydroguaiaretic acid, machilin A, Guaiacin, isoGuaiacin and isoGuaiacin dimethylether, from Machilus thunbergii, on osteoblast differentiation employing primary cultures of mouse osteoblast as an in vitro assay system. Among the six lignans tested, arylnaphthalene type lignans such as Guaiacin, isoGuaiacin and isoGuaiacin dimethylether significantly increased alkaline phosphatase activity, whereas bibenzylbutane type lignans such as meso-dihydroguaiaretic acid, nordihydroguaiaretic acid and machilin A showed little effects. IsoGuaiacin and isoGuaiacin dimethylether also increased collagen synthesis as well as calcium deposition. In addition, treatment of the mouse osteoblasts with tamoxifen markedly reduced ALP activity increased by isoGuaiacin or isoGuaiacin dimethylether, suggesting the involvement of estrogen receptor in the action of these lignans on osteoblast differentiation.
CONCLUSIONS:
Taken together, these results suggest that arylnaphthalene type lignans such as Guaiacin, isoGuaiacin and isoGuaiacin dimethylether significantly increase osteoblast differentiation.
Guaiacin Description
Source: The Leaves of Guaiacum officinale.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Clemastanin B

Catalog No: CFN95064
CAS No: 112747-98-5
Price: $298/10mg
Verbasoside

Catalog No: CFN95015
CAS No: 61548-34-3
Price: $318/5mg
Platycogenin A

Catalog No: CFN95240
CAS No: 1459719-53-9
Price: $388/5mg
Gardenin D

Catalog No: CFN95133
CAS No: 29202-00-4
Price: $318/5mg
Cordifolioside A

Catalog No: CFN95040
CAS No: 155179-20-7
Price: $318/10mg
Methyl ganoderenate D

Catalog No: CFN95572
CAS No: 748136-03-0
Price: $413/5mg
Methylpicraquassioside B

Catalog No: CFN95379
CAS No: 1443757-89-8
Price: $318/10mg
(R)-5,3'-Dimethyl hesperidin

Catalog No: CFN95310
CAS No: N/A
Price: $318/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.0451 mL 15.2253 mL 30.4507 mL 60.9013 mL 76.1267 mL
5 mM 0.609 mL 3.0451 mL 6.0901 mL 12.1803 mL 15.2253 mL
10 mM 0.3045 mL 1.5225 mL 3.0451 mL 6.0901 mL 7.6127 mL
50 mM 0.0609 mL 0.3045 mL 0.609 mL 1.218 mL 1.5225 mL
100 mM 0.0305 mL 0.1523 mL 0.3045 mL 0.609 mL 0.7613 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Kinase Assay:
J. Agr. Food Chem., 2007, 55(7):2569-74.
Lipoperoxidation and cyclooxygenases 1 and 2 inhibitory compounds from Iryanthera juruensis.[Pubmed: 17335225 ]
Plants from Iryanthera genus have been traditionally used as food supplements by South American Indians.
METHODS AND RESULTS:
The MeOH extract of leaves of Iryanthera juruensis, one of the plants endemic to the Amazon region and consumed in Brazil, and the hexane extract from its seeds inhibited lipid peroxidation (LPO) and cyclooxygenase (COX-1 and -2)) enzymes in in vitro assays. Further analyses of these extracts yielded 5-deoxyflavones (1-5) from the leaf extract and sargachromenol (6), sargaquinoic acid (7), a novel juruenolic acid (8), omega-arylalkanoic acids (9a-c), and the lignan Guaiacin (10) from the seed extract. Compounds 3-5 inhibited LPO by 86%, 77%, and 88% at 10 ppm, respectively, and compounds 6 and 9a-c showed inhibition at 76% and 78% at 100 ppm, respectively. However, compounds 7 and 8 were inactive and lignan 10 exhibited LPO inhibitory activity by 99% at 100 ppm compared to commercial antioxidants butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), and vitamin E. The flavones 1-5 also inhibited COX-1 and -2 enzymes by 50-65% at 100 ppm. Compound 6 showed high but nonselective inhibition of COX-1 and COX-2 enzymes, when compared to aspirin and Celebrex, a nonsteroidal anti-inflammatory drug (NSAID). Compounds 7 and 10 inhibited COX-1 by 60% and 65% and COX-2 by 37% and 18%, respectively, whereas compounds 8 and 9a-c showed little or no activity against these enzymes.
Cryptotanshinone

Catalog No: CFN98478
CAS No: 35825-57-1
Price: $30/20mg
Ganoderic acid F

Catalog No: CFN92055
CAS No: 98665-15-7
Price: $318/20mg
Kaempferol 3-O-beta-sophoroside

Catalog No: CFN92372
CAS No: 19895-95-5
Price: $268/20mg
3-oxo-Olean-12-en-28-oic acid

Catalog No: CFN92194
CAS No: 17990-42-0
Price: $90/20mg
Obtusifolin

Catalog No: CFN90394
CAS No: 477-85-0
Price: $268/20mg
Intermedine N-oxide

Catalog No: CFN00459
CAS No: 95462-14-9
Price: $ / mg
Betaine

Catalog No: CFN99546
CAS No: 107-43-7
Price: $30/20mg
Sugiol

Catalog No: CFN92187
CAS No: 511-05-7
Price: $ / mg
Cyclo(Pro-Leu)

Catalog No: CFN90281
CAS No: 5654-86-4
Price: $238/10mg
Notoginsenoside R1

Catalog No: CFN99999
CAS No: 80418-24-2
Price: $50/20mg
Tags: buy Guaiacin | Guaiacin supplier | purchase Guaiacin | Guaiacin cost | Guaiacin manufacturer | order Guaiacin | Guaiacin distributor