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    Natural Products
    Linderene
    Information
    CAS No. 26146-27-0 Price $268 / 10mg
    Catalog No.CFN90639Purity>=98%
    Molecular Weight230.3Type of CompoundSesquiterpenoids
    FormulaC15H18O2Physical DescriptionPowder
    Download COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $99.2 / In-stock
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    Linderene

    Linderene
    Product Name Linderene
    CAS No.: 26146-27-0
    Catalog No.: CFN90639
    Molecular Formula: C15H18O2
    Molecular Weight: 230.3 g/mol
    Purity: >=98%
    Type of Compound: Sesquiterpenoids
    Physical Desc.: Powder
    Source: The roots of Lindera aggregata( Sims) Kosterm
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $268 / 10mg
    Download: COA    MSDS    SDF
    Similar structural: Comparison (Web)  (SDF)
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Inhibitors Compound Library
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  • Biological Activity
    Description: Linderene, linderalactone and isolinderalactone inhibit the enzymes from both origins to the same extent.
    Linderene Description
    Source: The roots of Lindera aggregata( Sims) Kosterm
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.3422 mL 21.7108 mL 43.4216 mL 86.8432 mL 108.5541 mL
    5 mM 0.8684 mL 4.3422 mL 8.6843 mL 17.3686 mL 21.7108 mL
    10 mM 0.4342 mL 2.1711 mL 4.3422 mL 8.6843 mL 10.8554 mL
    50 mM 0.0868 mL 0.4342 mL 0.8684 mL 1.7369 mL 2.1711 mL
    100 mM 0.0434 mL 0.2171 mL 0.4342 mL 0.8684 mL 1.0855 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Kinase Assay:
    Biol Pharm Bull. 2002 Aug;25(8):1049-52.
    Prolyl endopeptidase inhibitors from the roots of Lindera strychnifolia F. Vill.[Pubmed: 12186408]
    We studied the PEP inhibitory constituents of the roots of Lindera strychnifolia F. VILL and isolated two known tannins, epicatechin (1) and aesculitannin B (2), and four known sesquiterpenes, Linderene (3), Linderene acetate (4), linderalactone (5) and isolinderalactone (6) as inhibitors.
    METHODS AND RESULTS:
    On the inhibitory activities of six compounds against PEP from Flavobacterium meningosepticum and that from rat brain supernatant, compounds 1, 2 and Linderene acetate inhibited the enzyme from Flavobacterium more strongly than that from rat brain supernatant. However, Linderene, linderalactone and isolinderalactone inhibited the enzymes from both origins to the same extent and furthermore, compound 6 was the strongest natural inhibitor against PEP from rat brain supernatant.
    CONCLUSIONS:
    The kinetic study of these inhibitors indicated that compounds 1, 2 are noncompetitive inhibitors and compounds Linderene,linderalactone,isolinderalactone are competitive inhibitors.
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