Phyllostine | CAS:27270-89-9 | Manufacturer ChemFaces

Phyllostine

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Phyllostine Description

Source:	From Pencillium urticae
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Can J Microbiol. 1979 Aug;25(8):881-7.

Patulin biosynthesis: the metabolism of phyllostine and isoepoxydon by cell-free preparations from Pencillium urticae.[Pubmed: 43192]

METHODS AND RESULTS:
Cell-free extracts of Penicillium urticae (NRRL 2159A), and its Pat- mutants, J2, J1, and S11, were found to contain significant NADP-dependent isoepoxydon dehydrogenase activity. This reversible interconversion of the epoxides (-)-Phyllostine and (+)-isoepoxydon occurred optimally at pH 5.8 and was completely inhibited by 1 mM p-chloromercuribenzoate (PCMB). The cytosol enzyme possessed specificity for both substrate and cofactor since neither (+)-epoxydon, an epimer of (+)-isoepoxydon, nor NADH was utilized. Cell extracts of the parent and of mutant J2, which is blocked before the epoxides in the patulin pathway, were found to convert Phyllostine and isoepoxydon to a number of unknown metabolites which appeared as yellow spots on thin-layer chromatograms after spraying with a chromogenic reagent. Extracts of mutant J1 were unable to carry out this conversion, while whole cells of mutant S11 accumulated what appeared to be these same 'yellow' compounds.
CONCLUSIONS:
Since PCMB-treated extracts of J2 converted Phyllostine but not isoepoxydon to these new metabolites, Phyllostine appeared to be their more immediate precursor. The relative positions of isoepoxydon and Phyllostine in the patulin pathway are discussed.

Product Name	Phyllostine
Price:
CAS No.:	27270-89-9
Catalog No.:	CFN97901
Molecular Formula:	C₇H₆O₄
Molecular Weight:	154.1 g/mol
Purity:	>=98%
Type of Compound:	Quinones
Physical Desc.:	Yellow powder
Source:	From Pencillium urticae
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
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Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Phytotoxic Compound Library Quinones Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	6.4893 mL	32.4465 mL	64.8929 mL	129.7859 mL	162.2323 mL
5 mM	1.2979 mL	6.4893 mL	12.9786 mL	25.9572 mL	32.4465 mL
10 mM	0.6489 mL	3.2446 mL	6.4893 mL	12.9786 mL	16.2232 mL
50 mM	0.1298 mL	0.6489 mL	1.2979 mL	2.5957 mL	3.2446 mL
100 mM	0.0649 mL	0.3245 mL	0.6489 mL	1.2979 mL	1.6223 mL

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CFN95676	Chimaphilin	482-70-2	186.2	C₁₂H₁₀O₂
CFN95672	7-(Hydroxymethyl)-2-methyl-1,4-naphthalenedione	145626-36-4	202.2	C₁₂H₁₀O₃
CFN95706	New compound 33	N/A	364.4	C₁₈H₂₀O₈
CFN91989	Droserone	478-40-0	204.18	C₁₁H₈O₄
CFN93018	Aristolindiquinone	86533-36-0	218.20	C₁₂H₁₀O₄
CFN97412	2-Methoxystypandrone	85122-21-0	260.2	C₁₄H₁₂O₅
CFN89245	Rubioncolin C	132242-52-5	442.46	C₂₇H₂₂O₆
CFN92932	3,3'-Bilawsone	33440-64-1	346.29	C₂₀H₁₀O₆
CFN98019	Isodiospyrin	20175-84-2	374.4	C₂₂H₁₄O₆