Quercetagetin | CAS:90-18-6 | Manufacturer ChemFaces

Quercetagetin

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Description:

Quercetagetin may be a potent inhibitor of the STAT1 signal, which could be a new molecular target for anti-inflammatory treatment, and may thus have therapeutic applications as an immune modulator in inflammatory diseases such as AD. It has stronger inhibitory effects on the protein and mRNA expression of TARC and MDC than other flavonoids.

Targets:

TARC | MDC | STAT

In vitro:

Biomolecules and Therapeutics, 2013, 21(2):138-145.

Anti-Inflammatory Effect of Quercetagetin, an Active Component of Immature Citrus unshiu, in HaCaT Human Keratinocytes.[Pubmed: 24009872 ]

Citrus fruit contain various flavonoids that have multiple biological activities. However, the content of these flavonoids are changed during maturation and immature Citrus is known to contain larger amounts than mature. Chemokines are significant mediators for cell migration, while thymus and activation-regulated chemokine (TARC/CCL17) and macrophage-derived chemokine (MDC/CCL22) are well known as the typical inflammatory chemokines in atopic dermatitis (AD), a pruritic and chronic inflammatory skin disease. We reported recently that the EtOH extract of immature Citrus unshiu inhibits TARC and MDC production.
METHODS AND RESULTS:
Therefore, we investigated the activity of flavonoids contained in immature Citrus on TARC and MDC levels. As a result, among the various flavonoids, Quercetagetin has stronger inhibitory effects on the protein and mRNA expression of TARC and MDC than other flavonoids. Quercetagetin particularly has better activity on TARC and MDC level than quercetin. In HPLC analysis, the standard peak of Quercetagetin matches the peaks of extract of immature C. unshiu.
CONCLUSIONS:
This suggests that Quercetagetin is an anti-inflammatory component in immature C. unshiu.

Quercetagetin Description

Source:	The herbs of Tagetes erecta L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Br J Dermatol. 2014 Sep;171(3):512-23.

Quercetagetin inhibits macrophage-derived chemokine in HaCaT human keratinocytes via the regulation of signal transducer and activator of transcription 1, suppressor of cytokine signalling 1 and transforming growth factor-β1.[Pubmed: 24602010 ]

Inflammatory chemokines, such as macrophage-derived chemokine (MDC/CCL22), are elevated in the serum and lesioned skin of patients with atopic dermatitis (AD), and are ligands for C-C chemokine receptor 4, which is predominantly expressed on T helper 2 lymphocytes, basophils and natural killer cells. We have previously reported that Quercetagetin has an inhibitory activity on inflammatory chemokines, which is induced by interferon (IFN)-γ and tumour necrosis factor (TNF)-α, occurring via inhibition of the signal transducer and activator of transcription 1 (STAT1) signal. To investigate the specific mechanisms of Quercetagetin on the STAT1 signal.
METHODS AND RESULTS:
We confirmed the inhibitory activity of Quercetagetin on MDC and STAT1 in HaCaT keratinocytes. The interaction between STAT1 and IFN-γR1 was investigated using immunoprecipitation. The small interfering RNA approach was used to investigate the role of suppressor of cytokine signalling 1 (SOCS1) and transforming growth factor (TGF)-β1 induced by Quercetagetin. Quercetagetin inhibited the expression of MDC at both the protein and mRNA levels in IFN-γ- and TNF-α-stimulated HaCaT human keratinocytes. Moreover, Quercetagetin inhibited the phosphorylation of STAT1 through upregulation of SOCS1. Increased expression of SOCS1 disrupted the binding of STAT1 to IFN-γR1. Furthermore, Quercetagetin augmented the expression of TGF-β1, which is known to modulate the immune response and inflammation.
CONCLUSIONS:
These results suggest that Quercetagetin may be a potent inhibitor of the STAT1 signal, which could be a new molecular target for anti-inflammatory treatment, and may thus have therapeutic applications as an immune modulator in inflammatory diseases such as AD.

Product Name	Quercetagetin
Price:	$338 / 20mg
CAS No.:	90-18-6
Catalog No.:	CFN93336
Molecular Formula:	C₁₅H₁₀O₈
Molecular Weight:	318.23 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The herbs of Tagetes erecta L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Flavonoids Compound Library STAT Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.1424 mL	15.7119 mL	31.4238 mL	62.8476 mL	78.5595 mL
5 mM	0.6285 mL	3.1424 mL	6.2848 mL	12.5695 mL	15.7119 mL
10 mM	0.3142 mL	1.5712 mL	3.1424 mL	6.2848 mL	7.856 mL
50 mM	0.0628 mL	0.3142 mL	0.6285 mL	1.257 mL	1.5712 mL
100 mM	0.0314 mL	0.1571 mL	0.3142 mL	0.6285 mL	0.7856 mL

CFN99616	3-O-Methylquercetin	1486-70-0	316.3	C₁₆H₁₂O₇
CFN99615	3-O-Methylquercetin tetraacetate	1486-69-7	484.4	C₂₄H₂₀O₁₁
CFN92328	beta-Rhamnocitrin	90-19-7	316.3	C₁₆H₁₂O₇
CFN96221	3,7-Di-O-methylquercetin	2068-02-2	330.3	C₁₇H₁₄O₇
CFN91810	4',5-Di-O-methyl quercetin	100648-56-4	330.3	C₁₇H₁₄O₇
CFN91809	3',5-Di-O-methyl quercetin	40554-94-7	330.3	C₁₇H₁₄O₇
CFN92429	5,7-Di-O-methylquercetin	13459-07-9	330.3	C₁₇H₁₄O₇
CFN91897	Gossypetin	489-35-0	318.24	C₁₅H₁₀O₈
CFN93336	Quercetagetin	90-18-6	318.23	C₁₅H₁₀O₈
CFN70462	Gossypetin 3-methylether	86749-51-1	332.3	C₁₆H₁₂O₈