ChemFaces is a professional high-purity natural products manufacturer.
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock |
10 mM * 1 mL in DMSO / Inquiry |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Food Chem.2020, 313:126079Nutrients.2018, 10(10)J Ethnopharmacol.2022, 282:114574. J Med Food.2021, 24(2):151-160.Front Cell Dev Biol.2021, 9:638174. Food Analytical Methods...2020...Appl. Sci. 2021, 11(23),11099.Drug Des Devel Ther.2020, 14:969-976.
Medicinal Chemistry Research ...2021...Univerzita Karlova2021, 20.500.11956.J Ethnopharmacol.2018, 210:88-94Drug Des Devel Ther.2020, 14:61-71J. of Med. Plant Research.2013, 90-151Pathogens.2018, 7(3):E62Int J Mol Med.2016, 37(2):501-8Iranian Journal of Pharmaceutical...2021...
Evid Based Complement Alternat Me...2018...Analytical methods2019, 11(6)Anal Bioanal Chem....2018...J Mol Histol.2019, 50(4):343-354Biomedicines.2021, 9(8):996.J Pharm Biomed Anal.2021, 196:113931. Pharmacognosy Journal...2019...
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Our products had been exported to the following research institutions and universities, And still growing.
Sant Gadge Baba Amravati Univer... (India)University of Illinois (USA)University of Pretoria (South Africa)Northeast Normal University Cha... (China)
Indian Institute of Science (India)Harvard University (USA)Texas A&M University (USA)Medizinische Universit?t Wien (Austria)
Florida International University (USA)University of Amsterdam (Netherlands)Universidade do Porto (Portugal)
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Quercetin 3,4'-dimethyl ether
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manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
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Fax:
+86-27-84254680
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Cancers (Basel).2021, 13(17):4327.Food Res Int.2018, 106:909-919Nutrients.2020, 12(3):595.J Sep Sci.2020, 201901140J Sep Sci.2018, 41(7):1682-1690Anal Biochem.2019, 569:10-15Plos One.2020, 10.1371Acta horticulturae2017, 1158:257-268Phytomedicine.2018, 38:45-56Eur J Pharmacol.2021, 899:174010.
Related Screening Libraries
Description: |
Quercetin 3,4’-dimethyl ether shows anti-lipid peroxidation activity (IC 50 values of 0.3 uM), it also shows anti-inflammatory activity. Quercetin 3,4’-dimethyl ether could be useful in the development of novel anticancer agents, it has high cytotoxic against leukemia cells, it induces cell death is mediated by an intrinsic dependent apoptotic event involving mitochondria and MAPKs, and through a mechanism independent of the generation of reactive oxygen species. |
Targets: |
Bcl-2/Bax | Caspase | JNK | ERK | MAPK |
In vitro: |
Arch.Pharm.Res., 2003, 26(7):535-9. | Antioxidant constituents from the stem of Sorghum bicolor.[Pubmed: 12934645] | METHODS AND RESULTS: The EtOAc soluble fraction from the stem of Sorghum bicolor showed a strong free radical scavenging activity.
Five major compounds were isolated from this fraction. They were identified by spectral data as methyl ferulate (1), methyl p-hydroxycinnamate (2), p-hydroxybenzaldehyde (3), tricin (4), and Quercetin 3,4'-dimethyl ether (5). Among these compounds, 1 exhibited a strong, free radical scavenging activity on 1,1-diphenyl-2-picrylhydrazyl (DPPH) with an IC50 value of 0.7 microM. We further studied the effects of these isolated compounds on the lipid peroxidation in rat liver microsomes induced by non-enzymatic method.
CONCLUSIONS:
All five compounds showed anti-lipid peroxidation activity (IC50 values of 0.5, 0.4, 0.3 and 0.3 microM, respectively). |
|
Quercetin 3,4'-dimethyl ether Description
Source: |
The branches of Tamarix chinensis Lour. |
Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
1 mM |
3.0276 mL |
15.1378 mL |
30.2755 mL |
60.551 mL |
75.6888 mL |
5 mM |
0.6055 mL |
3.0276 mL |
6.0551 mL |
12.1102 mL |
15.1378 mL |
10 mM |
0.3028 mL |
1.5138 mL |
3.0276 mL |
6.0551 mL |
7.5689 mL |
50 mM |
0.0606 mL |
0.3028 mL |
0.6055 mL |
1.211 mL |
1.5138 mL |
100 mM |
0.0303 mL |
0.1514 mL |
0.3028 mL |
0.6055 mL |
0.7569 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Kinase Assay: |
Mol. Carcinogen., 2010, 49(5): 464-75. | 5,7,3'-trihydroxy-3,4'-dimethoxyflavone-induced cell death in human leukemia cells is dependent on caspases and activates the MAPK pathway.[Pubmed: 20175127] | Flavonoids are polyphenolic compounds which display a vast array of biological activities and are promising anticancer agents. METHODS AND RESULTS: In this study we investigated the effect of 5,7,3'-trihydroxy-3,4'-dimethoxyflavone (Quercetin 3,4'-dimethyl ether,THDF) on viability of nine human tumor cell lines and found that it was highly cytotoxic against leukemia cells. THDF induced G(2)-M phase cell-cycle arrest and apoptosis through a caspase-dependent mechanism involving cytochrome c release, processing of multiple caspases (caspase-3, -6, -7, and -9) and cleavage of poly(ADP-ribose) polymerase. Overexpression of the protective mitochondrial proteins Bcl-2 and Bcl-x(L) conferred partial resistance to THDF-induced apoptosis.
CONCLUSIONS:
This flavonoid induced the phosphorylation of members of the mitogen-activated protein kinases (MAPKs) family and cell death was attenuated by inhibition of c-jun N-terminal kinases/stress-activated protein kinases (JNK/SAPK) and of extracellular signal-regulated kinases (ERK) 1/2. |
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