ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
3. Inhibitors
Citing Use of our Products
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Tel: (0086)-27-84237683
Fax: (0086)-27-84254680
E-mail: manager@chemfaces.com
Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $8.9 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Oncol Rep.2016, 35(3):1356-64Chem Pharm Bull (Tokyo)....2017...Appl. Sci.2021, 11(24),12080Int J Mol Sci.2019, 20(9):E2244J Med Food.2016, 19(12):1155-1165J Pharmaceut Biomed2020, 178:112894J Nat Sc Biol Med2019, 10(2):149-156Int J Mol Sci.2022, 23(15):8687.
Food Chem.2022, 378:131975.Environ Toxicol.2020, doi: 10.1002Antioxidants (Basel).2021, 10(9):1487.The Korea Journal of Herbology...2016...Nutrients.2018, 10(10)Iranian Journal of Pharmaceutical...2021...Reprod Toxicol.2020, 96:1-10. CZECH MYCOLOGY2021, 73(1):1-19.
Plants (Basel).2020, 9(11):1555.J Ethnopharmacol.2018, 210:88-94Metabolites2022, 12(6),507.Antioxidants (Basel).2021, 10(1):112. Int J Food Sci Nutr.2019, 70(7):825-833Food Chem Toxicol.2020, 135:110863Mol Cells.2015, 38(9):765-72
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Our products had been exported to the following research institutions and universities, And still growing.
National Cancer Center Research... (Japan)University of Queensland (Australia)University of Wuerzburg (Germany)University of Helsinki (Finland)
University of Lodz (Poland)Uniwersytet JagielloĊski w Kra... (Poland)Indian Institute of Science (India)Uniwersytet Medyczny w ?odzi (Poland)
University of Illinois at Chicago (USA)Universidade Federal de Pernamb... (Brazil)Universiti Malaysia Pahang (Malaysia)
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Sclareolide
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Toxicol Appl Pharmacol.2022, 434:115815.Biochem Biophys Res Commun.2021, 534:802-807.Front Microbiol.2022, 13:835463.J Biol Chem.2014, 289(3):1723-31Front Plant Sci.2022, 13:982771.J Liq Chromatogr R T2018, 41(12):761-769J Funct Foods2019, 54:449-456Antioxidants (Basel).2020, 9(7):581.Int J Cosmet Sci.2022, doi:10.1111/ics.12827.Food Sci Nutr.2019, 8(1):246-256
Related Screening Libraries
| Description: |
Sclareolide demonstrates a good antibacterial activity against Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27950, Escherichia coli ATCC 25922 and Enterococcus faecalis ATCC 29212. Sclareolide enhances gemcitabine‑induced cell death through mediating the NICD and Gli1 pathways in gemcitabine‑resistant human pancreatic cancer. |
| Targets: |
Antifection |
| In vitro: |
| Pak J Pharm Sci. 2007 Apr;20(2):146-8. | | Antibacterial and cytotoxic activity of the acetone extract of the flowers of Salvia sclarea and some natural products.[Pubmed: 17416571] | The aim of this study was to investigate the antibacterial and the cytotoxic activity of the acetone extract of the flowers of Salvia sclarea and of some natural products (sclareol, Sclareolide and ambrox).
METHODS AND RESULTS:
The antibacterial and the cytotoxic activity were determined by the dilution method. Sclareolide, ambrox and sclareol demonstrated a good antibacterial activity against Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27950, Escherichia coli ATCC 25922 and Enterococcus faecalis ATCC 29212. The acetonic extract of the flowers of Salvia sclarea has a significant cytotoxic activity against Hep-2 cells. |
|
Sclareolide Description
| Source: |
The herbs of Perilla frutescens. |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
3.9939 mL |
19.9696 mL |
39.9393 mL |
79.8786 mL |
99.8482 mL |
| 5 mM |
0.7988 mL |
3.9939 mL |
7.9879 mL |
15.9757 mL |
19.9696 mL |
| 10 mM |
0.3994 mL |
1.997 mL |
3.9939 mL |
7.9879 mL |
9.9848 mL |
| 50 mM |
0.0799 mL |
0.3994 mL |
0.7988 mL |
1.5976 mL |
1.997 mL |
| 100 mM |
0.0399 mL |
0.1997 mL |
0.3994 mL |
0.7988 mL |
0.9985 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
| Kinase Assay: |
| Mol Med Rep. 2017 Apr;15(4):1461-1470. | | Sclareolide enhances gemcitabine‑induced cell death through mediating the NICD and Gli1 pathways in gemcitabine‑resistant human pancreatic cancer.[Pubmed: 28259943 ] | Pancreatic cancer is a type of cancer, which rapidly develops resistance to chemotherapy. Gemcitabine is the treatment used clinically, however, gemcitabine resistance leads to limited efficacy and patient survival rates of only a few months following diagnosis.
METHODS AND RESULTS:
The aim of the present study was to investigate the mechanisms underlying gemcitabine resistance in pancreatic cancer and to select targeted agents combined with gemcitabine to promote the treatment of pancreatic cancer. Panc‑1 and ASPC‑1 human pancreatic cancer cells (HPCCs) were used to establish the experimental model, and HPCCs were exposed to gemcitabine of serially increased concentrations to generate gemcitabine‑resistant cells (GR‑HPCCs). The anticancer effect of gemcitabine combined with Sclareolide was then assessed. Epithelial to mesenchymal transition (EMT), human equilibrative nucleoside transporter 1 (hENT1) and ribonucleoside diphosphate reductase 1 (RRM1) were detected in the HPCCs and GR‑HPCCs, and the mechanisms were investigated. Sclareolide resensitized the GR‑HPCCs to gemcitabine. The expression levels of hENT1 and RRM1 were lower and higher, respectively, in GR‑HPCCs, compared with HPCCs. Sclareolide upregulated hENT1, downregulated RRM1 and inhibited gemcitabine‑induced EMT through the TWIST1/Slug pathway in the GR‑HPCCs. In addition, Sclareolide mediated the NOTCH 1 intracellular cytoplasmic domain (NICD)/glioma‑associated oncogene 1 (Gli1) pathway, which triggered TWIST1/Slug‑hENT1/RRM1 signaling and resensitized GR‑HPCCs to gemcitabine. Finally, Sclareolide resensitized GR‑HPCCs to gemcitabine through inducing apoptosis; in vivo, the co‑administraion of Sclareolide and gemcitabine effectively suppressed tumor growth.
CONCLUSIONS:
Sclareolide may be a novel agent in combination with gemcitabine for the treatment of gemcitabine‑resistant pancreatic cancer, which resensitizes GR‑HPCCs to gemcitabine through mediating NICD and Gli1. |
|
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