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Specioside
Specioside
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Specioside
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CAS No.: 72514-90-0
Catalog No.: CFN97207
Molecular Formula: C24H28O12
Molecular Weight: 508.5 g/mol
Purity: >=98%
Type of Compound: Iridoids
Physical Desc.: Powder
Source: The herbs of Callicarpa giraldiana
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Specioside has antioxidant, analgesic, anti-dyspeptic, astringent, liver stimulating and wound healing activities. It ameliorates oxidative stress and promotes longevity in Caenorhabditis elegans.
Targets: SOD
In vitro:
Arch Pharm Res. 2009 Feb;32(2):207-13.
Antioxidative iridoid glycosides and phenolic compounds from Veronica peregrina.[Pubmed: 19280150 ]

METHODS AND RESULTS:
Eight iridoid glycosides and four phenolic compounds were isolated from the EtOAc soluble fraction of Veronica peregrina MeOH extract as the radical scavengers for antioxidant activity. The compounds were identified as protocatechuic acid (1), luteolin (2), veronicoside (3), minecoside (4), Specioside (5), amphicoside (6), catalposide (7), 6-O-cis-p-coumaroyl catalpol (8), p-hydroxy benzoic acid methyl ester (9), verproside (10), verminoside (11), and chrysoeriol 7-glucuronide (12) by spectroscopic analysis. All compounds except for 1 and 2 were isolated for the first time from this plant. The antioxidant activity was evaluated by the ORAC(Oxygen Radical Absorbance Capacity) assay, which measures scavenging activity against peroxy radicals induced by 2,2'-azobis (2-methoxypropion-amidine) dihydrochloride, and the ORAC value is expressed as relative trolox equivalent.
CONCLUSIONS:
Compounds 2, 4, 5, 6, 8, and 12 exhibited potent antioxidant activity, and compounds 1, 11 had similar activity with trolox, whereas the other compounds showed weaker activity than trolox.
Specioside Description
Source: The herbs of Callicarpa giraldiana
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.9666 mL 9.8328 mL 19.6657 mL 39.3314 mL 49.1642 mL
5 mM 0.3933 mL 1.9666 mL 3.9331 mL 7.8663 mL 9.8328 mL
10 mM 0.1967 mL 0.9833 mL 1.9666 mL 3.9331 mL 4.9164 mL
50 mM 0.0393 mL 0.1967 mL 0.3933 mL 0.7866 mL 0.9833 mL
100 mM 0.0197 mL 0.0983 mL 0.1967 mL 0.3933 mL 0.4916 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Animal Research:
Comp Biochem Physiol C Toxicol Pharmacol. 2015 Mar;169:25-34.
Specioside ameliorates oxidative stress and promotes longevity in Caenorhabditis elegans.[Pubmed: 25619942]
Specioside (6-O-coumaroylcatalpol) is an iridoid glucoside which possesses multifunctional activities viz. analgesic, antidyspeptic, astringent, liver stimulating and wound healing properties. The present study for the first time delineates stress alleviating and lifespan prolonging action of Specioside (SPC), isolated from Stereospermum suaveolens in the free living, multicellular nematode model Caenorhabditis elegans.
METHODS AND RESULTS:
A strong correlation between lifespan extension and stress modulation in adult worms was established in a dose dependent manner. The dietary intake of this phytomolecule elevated juglone induced oxidative and heat induced thermal stress tolerance in C. elegans. On evaluation, it was found that 25 μM dose of Specioside significantly extended lifespan by 15.47% (P≤0.0001) with reduction in stress level. Furthermore, Specioside enhanced mean survival in mev-1 mutant suggesting its oxidative stress reducing potential. Furthermore, Specioside augmented stress modulatory enzymes superoxide dismutase (SOD) and catalase (CAT) level in C. elegans.
CONCLUSIONS:
Altogether, these findings broaden current perspectives concerning stress alleviating potentials of Specioside and have implications in development of therapeutics for curing age related disorders.
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