Info: Read More
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • How to Order
  • Delivery time
  • Science | Nature | Cell | View More
    Natural Products
    Usnic acid
    Information
    CAS No. 7562-61-0 Price $30 / 20mg
    Catalog No.CFN97236Purity>=98%
    Molecular Weight344.3 Type of CompoundPhenols
    FormulaC18H16O7Physical DescriptionYellow powder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
    Citing Use of our Products
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email: info@chemfaces.com
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $10.8 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
  • Universidad Miguel Hernández (Spain)
  • Hamdard University (India)
  • University of Mysore (India)
  • MTT Agrifood Research Finland (Finland)
  • Siksha O Anusandhan University (India)
  • Instytut Nawozów Sztucznych w ... (Poland)
  • Istanbul University (Turkey)
  • Massachusetts General Hospital (USA)
  • Shanghai Institute of Organic C... (China)
  • Shanghai Institute of Biochemis... (China)
  • Nanjing University of Chinese M... (China)
  • More...
  • Package
    Featured Products
    Isochamaejasmine

    Catalog No: CFN92150
    CAS No: 93859-63-3
    Price: $418/5mg
    Ganoderenic acid D

    Catalog No: CFN90300
    CAS No: 100665-43-8
    Price: $458/10mg
    Rebaudioside B

    Catalog No: CFN90470
    CAS No: 58543-17-2
    Price: $238/20mg
    Isoliquiritin apioside

    Catalog No: CFN90800
    CAS No: 120926-46-7
    Price: $288/10mg
    Ginsenoside Compound K

    Catalog No: CFN99756
    CAS No: 39262-14-1
    Price: $100/20mg
    Mulberroside A

    Catalog No: CFN99586
    CAS No: 102841-42-9
    Price: $100/20mg
    Ganoderic acid S

    Catalog No: CFN99066
    CAS No: 104759-35-5
    Price: $568/5mg

    Usnic acid

    Usnic acid
    Product Name Usnic acid
    CAS No.: 7562-61-0
    Catalog No.: CFN97236
    Molecular Formula: C18H16O7
    Molecular Weight: 344.3 g/mol
    Purity: >=98%
    Type of Compound: Phenols
    Physical Desc.: Yellow powder
    Targets: Calcium Channel | Autophagy | Caspase | JNK | SOD | TNF-伪 | IL Receptor | NOS | Antifection
    Source: From usnea diffracta Vain.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $30 / 20mg
    Inquire / Order: manager@chemfaces.com
    Technical Inquiries: service@chemfaces.com
    Tel: +86-27-84237783
    Fax: +86-27-84254680

    Address:
    1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
  • Chemistry of Natural Compounds2018, 54(3):572–576
  • Food Res Int.2018, 106:909-919
  • Pharmaceutics.2020, 12(9):845.
  • Biosci Biotechnol Biochem.2020, 84(3):621-632
  • J Chromatogr B Analyt Technol Biomed Life Sci.2018, 1080:27-36
  • J Cell Mol Med.2018, 22(9):4236-4242
  • Int J Mol Sci.2019, 20(11):E2734
  • Primary and Industrial.2018, 52(11)
  • Food Funct.2020, 10.1039
  • Front Immunol.2020, 11:598556.
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Anticancer Compound Library
  • Anti-inflammatory Compound Library
  • Antioxidants Compound Library
  • Inhibitors Compound Library
  • Antifungal Compound Library
  • Insecticides Compound Library
  • Anti-photoaging Compound Library
  • Herbicides Compound Library
  • Gastro-protective Compound Library
  • Antipyretic Compound Library
  • Wound-healing Compound Library
  • Hepatotoxicity Compound Library
  • Phenols Compound Library
  • TNF-α Inhibitor Library
  • SOD Inhibitor Library
  • NOS Inhibitor Library
  • JNK Inhibitor Library
  • IL Receptor Inhibitor Library
  • Caspase Inhibitor Library
  • Calcium Channel Inhibitor Library
  • Autophagy Inhibitor Library
  • Antifection Inhibitor Library
  • Biological Activity
    Description: Usnic acid has antitumoral, acaricidal, larvicidal, antiviral, antibiotic, antipyretic, analgesic,gastroprotective, antioxidative and anti-inflammatory activities. Use of reconstituted bovine type-I collagen-based films containing usnic acid can improve burn healing process in rats. Usnic acid perturbs various interrelated signaling pathways and that autophagy induction is a defensive mechanism against usnic acid-induced cytotoxicity; it disturbs calcium homeostasis, induces ER stress, and that Usnic acid-induced cellular damage occurs at least partially via activation of the Ca(2+) channel of SOCE.
    Targets: Calcium Channel | Autophagy | Caspase | JNK | SOD | TNF-α | IL Receptor | NOS | Antifection
    In vitro:
    Parasitol Res. 2014 Jun;113(6):2387-90.
    Acaricidal activity of usnic acid and sodium usnic acid against Psoroptes cuniculi in vitro.[Pubmed: 24770718]
    Usnic acid, a major active compound in lichens, was first isolated in 1884. Since then, Usnic acid and its sodium salt (sodium Usnic acid) have been used in medicine, perfumery, cosmetics, and other industries due to its extensive biological activities. However, its acaricidal activity has not been studied. In this paper, we investigated the acaricidal activity of Usnic acid and sodium Usnic acid against Psoroptes cuniculi in vitro.
    METHODS AND RESULTS:
    After evaluating the acaricidal activity and toxicity of Usnic acid and sodium Usnic acid in vitro, the results showed that at doses of 250, 125, and 62.5 mg/ml, Usnic acid and sodium Usnic acid can kill mites with 91.67, 85.00, and 55.00% and 100, 100, and 60.00% mortality after treatment 24 h. The LT50 values were 4.208, 8.249, and 16.950 h and 3.712, 7.339, and 15.773 h for Usnic acid and sodium Usnic acid, respectively.
    CONCLUSIONS:
    Sodium Usnic acid has a higher acaricidal activity than Usnic acid, which may be related to the difference in their structures.
    Z Naturforsch C. 2006 Nov-Dec;61(11-12):773-6.
    Identification and quantitation of usnic acid from the lichen Usnea species of Anatolia and antimicrobial activity.[Pubmed: 17294685]
    Six species of lichens, such as Usnea florida, Usnea barbata, Usnea longissima, Usnea rigida, Usnea hirta and Usnea subflorida, were collected from different areas of Anatolia (district of Antalya, Karabük, Qankiri, Giresun and Trabzon) in Turkey.
    METHODS AND RESULTS:
    Their Usnic acid amounts in acetone extracts were determined by HPLC. In addition, antimicrobial activities of these extracts were determined against Escherichia coli (ATCC 35218), Enterococcus faecalis (RSKK 508), Proteus mirabilis (Pasteur Ens. 235), Staphylococcus aureus, Bacillus subtilis and Bacillus megaterium.
    CONCLUSIONS:
    It was shown that with increasing amount of Usnic acid, the antimicrobial activity increased. Usnic acid contents of Usnea species varied between 0.22-6.49% of dry weight.
    Lat. Am. J. Pharm., 2009, 300(2): R349-60.
    Larvicidal Activity of Cladonia substellata Extract and Usnic Acid against Aedes aegypti and Artemia salina[Reference: WebLink]
    The chloroform extract of Cladonia substellata Vainio was assayed against larvae of Aedes ae- gypti, the mosquito vector of Dengue fever and Artemia salina.
    METHODS AND RESULTS:
    The extract was tested at concentrations ranging from 1 to 15 ppm in an aqueous medium for 24 h. LC50 and LC90 were evaluated. Since the chlo- roform extract proved to be lethal for third to fourth instar larvae, downstream processing was undertak- en to purify the active agents in the extract. The major compound in the chloroform extract was purified by crystallization followed by column chromatography to yield yellow crystals. Furthermore, Usnic acid (UA) was evaluated for its larvicidal potential. The major compound in the chloroform extract, UA, exhib- ited LC50 of 6.6 ppm (6.1 to 7.0 ppm). Therefore, UA is most likely the active principle in C. substellata.
    CONCLUSIONS:
    UA showed to be toxic to A. salina, a reference organism in assays to evaluate the potential toxicity hazard to invertebrates in ecosystems.
    In vivo:
    Int Immunopharmacol. 2014 Oct;22(2):371-8.
    Usnic acid protects LPS-induced acute lung injury in mice through attenuating inflammatory responses and oxidative stress.[Pubmed: 25068825]
    Usnic acid is a dibenzofuran derivative found in several lichen species, which has been shown to possess several activities, including antiviral, antibiotic, antitumoral, antipyretic, analgesic, antioxidative and anti-inflammatory activities. However, there were few reports on the effects of Usnic acid on LPS-induced acute lung injury (ALI). The aim of our study was to explore the effect and possible mechanism of Usnic acid on LPS-induced lung injury.
    METHODS AND RESULTS:
    In the present study, we found that pretreatment with Usnic acid significantly improved survival rate, pulmonary edema. In the meantime, protein content and the number of inflammatory cells in bronchoalveolar lavage fluid (BALF) significantly decreased, and the levels of MPO, MDA, and H2O2 in lung tissue were markedly suppressed after treatment with Usnic acid. Meanwhile, the activities of SOD and GSH in lung tissue significantly increased after treatment with Usnic acid. Additionally, to evaluate the anti-inflammatory activity of Usnic acid, the expression of pro-inflammatory cytokines including tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6) and anti-inflammatory cytokine IL-10, and chemokines interleukin-8 (IL-8) and macrophage inflammatory protein-2 (MIP-2) in BALF were studied. The results in the present study indicated that Usnic acid attenuated the expression of TNF-α, IL-6, IL-8 and MIP-2. Meanwhile, the improved level of IL-10 in BALF was observed.
    CONCLUSIONS:
    In conclusion, these data showed that the protective effect of Usnic acid on LPS-induced ALI in mice might relate to the suppression of excessive inflammatory responses and oxidative stress in lung tissue. Thus, it was suggested that Usnic acid might be a potential therapeutic agent for ALI.
    J Biomed Biotechnol. 2011;2011:761593.
    Collagen-based films containing liposome-loaded usnic acid as dressing for dermal burn healing.[Pubmed: 21274404]
    The aim of this study was assess the effect of collagen-based films containing Usnic acid as a wound dressing for dermal burn healing.
    METHODS AND RESULTS:
    Second-degree burn wounds were performed in forty-five Wistar rats, assigned into nine groups: COL-animals treated with collagen-based films; PHO-animals treated with collagen films containing empty liposomes; UAL-animals treated with collagen-based films containing Usnic acid incorporated into liposomes. After 7, 14, and 21 days the animals were euthanized. On 7th day there was a moderate infiltration of neutrophils, in UAL, distributed throughout the burn wounds, whereas in COL and PHO, the severity of the reaction was slighter and still limited to the margins of the burn wounds. On the 14th day, the inflammatory reaction was less intense in UAL, with remarkable plasma cells infiltration. On the 21st day, there was reduction of the inflammation, which was predominantly composed of plasma cells in all groups, particularly in UAL. The use of the Usnic acid provided more rapid substitution of type-III for type-I collagen on the 14th day, and improved the collagenization density on the 21st day.
    CONCLUSIONS:
    It was concluded that the use of reconstituted bovine type-I collagen-based films containing Usnic acid improved burn healing process in rats.
    Usnic acid Description
    Source: From usnea diffracta Vain.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    ChemFaces New Products and Compounds
    Sotetsuflavone

    Catalog No: CFN93257
    CAS No: 2608-21-1
    Price: $368/5mg
    Selaginellin F

    Catalog No: CFN95029
    CAS No: 1340493-24-4
    Price: $413/5mg
    Cyclo(Hyp-Val)

    Catalog No: CFN91062
    CAS No: 1425501-89-8
    Price: $332/10mg
    Dioscoreside C

    Catalog No: CFN95345
    CAS No: 344912-80-7
    Price: $318/5mg
    2-Methoxyfuranoguaia-9-ene-8-one

    Catalog No: CFN95220
    CAS No: 88010-62-2
    Price: $318/10mg
    Zederone

    Catalog No: CFN92616
    CAS No: 7727-79-9
    Price: $278/20mg
    Syringaresinol

    Catalog No: CFN92060
    CAS No: 487-35-4
    Price: $268/5mg
    (+)-Lyoniresinol 9'-O-glucoside

    Catalog No: CFN97964
    CAS No: 87585-32-8
    Price: $418/5mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.9044 mL 14.5222 mL 29.0444 mL 58.0889 mL 72.6111 mL
    5 mM 0.5809 mL 2.9044 mL 5.8089 mL 11.6178 mL 14.5222 mL
    10 mM 0.2904 mL 1.4522 mL 2.9044 mL 5.8089 mL 7.2611 mL
    50 mM 0.0581 mL 0.2904 mL 0.5809 mL 1.1618 mL 1.4522 mL
    100 mM 0.029 mL 0.1452 mL 0.2904 mL 0.5809 mL 0.7261 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Kinase Assay:
    Toxicol Sci. 2015 Jul;146(1):116-26.
    Endoplasmic Reticulum Stress and Store-Operated Calcium Entry Contribute to Usnic Acid-Induced Toxicity in Hepatic Cells.[Pubmed: 25870318 ]
    The use of Usnic acid as a weight loss agent is a safety concern due to reports of acute liver failure in humans. Previously we demonstrated that Usnic acid induces apoptosis and cytotoxicity in hepatic HepG2 cells. We also demonstrated that Usnic acid induces autophagy as a survival mechanism against its cytotoxicity. In this study, we investigated and characterized further molecular mechanisms underlying the toxicity of Usnic acid in HepG2 cells.
    METHODS AND RESULTS:
    We found that Usnic acid causes endoplasmic reticulum (ER) stress demonstrated by the increased expression of typical ER stress markers, including CHOP, ATF-4, p-eIF2α, and spliced XBP1. Usnic acid inhibited the secretion of Gaussia luciferase measured by an ER stress reporter assay. An ER stress inhibitor 4-phenylbutyrate attenuated Usnic acid-induced apoptosis. Moreover, Usnic acid significantly increased the cytosolic free Ca(2+) concentration. Usnic acid increased the expression of calcium release-activated calcium channel protein 1 (CRAM1 or ORAI1) and stromal interaction molecule 1, two key components of store-operated calcium entry (SOCE), which is the major Ca(2+) influx pathway in non-excitable cells, this finding was also confirmed in primary rat hepatocytes. Furthermore, knockdown of ORAI1 prevented ER stress and ATP depletion in response to Usnic acid. In contrast, overexpression of ORAI1 increased ER stress and ATP depletion caused by Usnic acid.
    CONCLUSIONS:
    Taken together, our results suggest that Usnic acid disturbs calcium homeostasis, induces ER stress, and that Usnic acid-induced cellular damage occurs at least partially via activation of the Ca(2+) channel of SOCE.
    Toxicol Sci. 2014 Nov;142(1):33-44.
    The role of autophagy in usnic acid-induced toxicity in hepatic cells.[Pubmed: 25078063]
    The use of Usnic acid and Usnic acid-containing products is associated with acute liver failure; however, mechanistic studies of hepatotoxicity caused by Usnic acid are limited. In this study, we investigated and characterized the possible mechanisms, especially the role of autophagy in Usnic acid's toxicity in human HepG2 cells.
    METHODS AND RESULTS:
    Usnic acid caused apoptosis as demonstrated by an increased caspase-3/7 activity and an increased subdiploid nucleus formation. Usnic acid-induced autophagy as demonstrated by the conversion of LC3B-I to LC3B-II, degradation of P62, and an increased number of puncta. Inhibition of autophagy by treating cells with autophagy inhibitors (3-methyladenine or chloroquine) or by small interfering RNA against Atg7 aggravated Usnic acid-induced apoptosis and decreased cell viability, indicating that autophagy plays a protective role against Usnic acid-induced toxicity. Moreover, Usnic acid activated the MAPK signaling pathway. Usnic acid-elicited apoptosis was enhanced and autophagy was decreased when JNK was suppressed by a specific inhibitor. Additionally, inhibition of autophagy decreased the activity of JNK.
    CONCLUSIONS:
    Taken together, our results suggest that Usnic acid perturbs various interrelated signaling pathways and that autophagy induction is a defensive mechanism against Usnic acid-induced cytotoxicity.
    Animal Research:
    J Ethnopharmacol. 2006 Jan 3;103(1):59-65.
    Gastroprotective and antioxidant effects of usnic acid on indomethacin-induced gastric ulcer in rats.[Pubmed: 16169175 ]
    Usnea longissima, a medicinal lichen of Anatolia (Turkey), is used in the treatment of gastric ulcer in local folk medicine.
    METHODS AND RESULTS:
    In this paper, the gastroprotective effect of Usnic acid (UA) isolated from Usnea longissima was investigated in the indomethacin-induced gastric ulcers in rats at doses of 25, 50, 100 and 200 mg/kg body weight. The gastric lesions were significantly reduced by all doses of UA as compared with the indomethacin (25 mg/kg body weight) treated group. In the stomach tissues of treated animals, the in vivo antioxidant levels were evaluated. The administration of indomethacin caused a significant decrease in the levels of superoxide dismutase (SOD), glutathione peroxidase (GPx) and reduced glutathione (GSH), and an increase in the lipid peroxidation (LPO) level (p < 0.05). The administration of all doses of UA reversed the trend, inducing a significant increase of SOD, GSH and GPx levels and a reduction in LPO level in tissues. However, catalase (CAT), glutathione reductase (GR) and myeloperoxidase (MPx) activities, increased by indomethacin, were found to be lower in the UA- and ranitidine-treated groups. The gastric mucosal constitutive NO synthase (cNOS) and inducible NO synthase (iNOS) activities were also investigated in tissues of UA- (100 mg/kg), ranitidine- (50 mg/kg) and indomethacin-treated rat groups. The administration of UA and ranitidine increased the cNOS activity and lowered the iNOS activity as compared with indomethacin-treated group.
    CONCLUSIONS:
    These results suggest that the gastroprotective effect of UA can be attributed to its reducing effect on the oxidative damage and neutrophil infiltration in tissues.
    Isochamaejasmine

    Catalog No: CFN92150
    CAS No: 93859-63-3
    Price: $418/5mg
    Ganoderenic acid D

    Catalog No: CFN90300
    CAS No: 100665-43-8
    Price: $458/10mg
    Rebaudioside B

    Catalog No: CFN90470
    CAS No: 58543-17-2
    Price: $238/20mg
    Isoliquiritin apioside

    Catalog No: CFN90800
    CAS No: 120926-46-7
    Price: $288/10mg
    Ginsenoside Compound K

    Catalog No: CFN99756
    CAS No: 39262-14-1
    Price: $100/20mg
    Mulberroside A

    Catalog No: CFN99586
    CAS No: 102841-42-9
    Price: $100/20mg
    Ganoderic acid S

    Catalog No: CFN99066
    CAS No: 104759-35-5
    Price: $568/5mg